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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/09/08 18:13:03」(JST)

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Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.^[3]

Function

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes^[4] through binding to the receptors CCR1, CCR4 and CCR5.^[3]

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).^[5]^[3]

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.^[6]

Interactions

CCL3 has been shown to interact with CCL4.^[7] Attracts macrophages, monocytes and neutrophils.

References

^ ^a ^b ^c ENSG00000277632, ENSG00000274221 GRCh38: Ensembl release 89: ENSG00000278567, ENSG00000277632, ENSG00000274221 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ ^a ^b ^c "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
^ Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine. 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834 . PMID 3279154.
^ Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160 . PMID 3058856.
^ Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science. 243 (4894 Pt 1): 1066–8. doi:10.1126/science.2646711. PMID 2646711.
^ Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

External links

Human CCL3 genome location and CCL3 gene details page in the UCSC Genome Browser.

UpToDate Contents

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English Journal

Hepatic topographical changes of endoplasmic reticulum stress and unfolded protein response signaling after hemorrhagic shock and reperfusion.

Wolpert A1, Obert D2, Frey B2, Lee YS3, Korff S2.
The Journal of surgical research.J Surg Res.2018 Nov;231:278-289. doi: 10.1016/j.jss.2018.05.060. Epub 2018 Jun 23.
PMID 30278941

The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers.

Staversky RJ1, Byun DK1, Georger MA2, Zaffuto BJ2, Goodman A1, Becker MW1,3, Calvi LM1,2,3,4, Frisch BJ5,6,7.
Scientific reports.Sci Rep.2018 Oct 2;8(1):14691. doi: 10.1038/s41598-018-32978-y.
PMID 30279500

Anti-inflammatory effects of the GAG-binding CXCL9(74-103) peptide in dinitrofluorobenzene-induced contact hypersensitivity in mice.

Vanheule V1, Crijns H1, Poosti F1, Ruytinx P1, Berghmans N1, Gerlza T2,3, Ronsse I1, Pörtner N1, Matthys P4, Kungl AJ2,3, Opdenakker G4, Struyf S1, Proost P1.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.Clin Exp Allergy.2018 Oct;48(10):1333-1344. doi: 10.1111/cea.13227. Epub 2018 Aug 14.
PMID 29978510

Japanese Journal

Crucial involvement of the CCL3-CCR5 axis-mediated fibroblast accumulation in colitis-associated carcinogenesis in mice

Sasaki Soichiro,Baba Tomohisa,Shinagawa Kei,Matsushima Kouji,Mukaida Naofumi
International Journal of Cancer 135(6), 1297-1306, 2014-09-15
… AOM/DSS-induced tumor formation was reduced in CCL3- or its specific receptor, CCR5-deficient mice despite the presence of a massive infiltration of inflammatory cells. … However, AOM/DSS-induced type I collagen-positive fibroblast accumulation in the colon was reduced in CCL3- or CCR5-deficient mice. … Moreover in vitro, CCL3 induced fibroblasts to proliferate and to enhance HB-EGF expression. …
NAID 120005463351

Differences in the Toxicities of Trichothecene Mycotoxins, Deoxynivalenol and Nivalenol, in Cultured Cells

NAGASHIMA Hitoshi,NAKAGAWA Hiroyuki
Japan Agricultural Research Quarterly: JARQ 48(4), 393-397, 2014
… While exposure to DON significantly induced the secretion of anti-hematopoietic cytokines macrophage inflammatory protein-1α (MIP-1α/CCL3) and MIP-1β/CCL4, treatment with NIV decreased the secretion of these cytokines in HL60 cells, indicating that the toxicity mechanisms of these toxins differ. …
NAID 130004701841

Lactobacillus acidophilus L-92 Cells Activate Expression of Immunomodulatory Genes in THP-1 Cells

YANAGIHARA Sae,GOTO Hiroaki,HIROTA Tatsuhiko,FUKUDA Shinji,OHNO Hiroshi,YAMAMOTO Naoyuki
Bioscience of Microbiota, Food and Health 33(4), 157-164, 2014
… In the early phase of L-92 treatment, various transcription regulator genes, such as, NFkB1, NFkB2, JUN, HIVEP2 and RELB, and genes encoding chemokines and cytokines, such as CCL4, CXCL11, CCL3 and TNF, were upregulated. …
NAID 130004680094

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★リンクテーブル★

リンク元	「MIP-1α」
拡張検索	「ケモカインCCL3」「chemokine CCL3」
関連記事	「CC」「CCL」

「MIP-1α」

CCL3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR
Identifiers
Aliases	CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3
External IDs	OMIM: 182283 HomoloGene: 88430 GeneCards: CCL3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	36,090,169 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• protein kinase activity; • cytokine activity; • CCR5 chemokine receptor binding; • chemokine activity; • CCR1 chemokine receptor binding; • kinase activity; • phospholipase activator activity; • calcium-dependent protein kinase C activity; • protein binding; • identical protein binding; • chemoattractant activity;
Cellular component	• cytoplasm; • cytosol; • intracellular; • extracellular region; • extracellular space;
Biological process	• G-protein coupled receptor signaling pathway; • signaling; • negative regulation of bone mineralization; • positive regulation of protein kinase B signaling; • release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; • response to cholesterol; • positive regulation of calcium-mediated signaling; • regulation of sensory perception of pain; • protein kinase B signaling; • monocyte chemotaxis; • negative regulation of osteoclast differentiation; • astrocyte cell migration; • positive regulation of cell migration; • positive regulation of natural killer cell chemotaxis; • chemokine-mediated signaling pathway; • T cell chemotaxis; • cell-cell signaling; • cellular response to tumor necrosis factor; • eosinophil chemotaxis; • cellular response to organic cyclic compound; • cellular calcium ion homeostasis; • negative regulation of gene expression; • neutrophil chemotaxis; • cell activation; • MAPK cascade; • chemotaxis; • positive regulation of GTPase activity; • positive regulation of neuron apoptotic process; • positive regulation of calcium ion import; • macrophage chemotaxis; • positive regulation of gene expression; • cytoskeleton organization; • positive regulation of interleukin-1 beta secretion; • osteoblast differentiation; • cellular response to interleukin-1; • immune response; • positive regulation of ERK1 and ERK2 cascade; • regulation of cell shape; • positive regulation of tumor necrosis factor production; • cellular response to interferon-gamma; • lymphocyte chemotaxis; • inflammatory response; • granulocyte chemotaxis; • response to toxic substance; • eosinophil degranulation; • lipopolysaccharide-mediated signaling pathway; • calcium ion transport; • calcium-mediated signaling; • exocytosis; • positive regulation of calcium ion transport; • positive chemotaxis; • positive regulation of inflammatory response; • regulation of receptor activity; • cytokine-mediated signaling pathway; • regulation of behavior;
	Sources:Amigo / QuickGO
Orthologs
	6348
	n/a
	ENSG00000278567; ENSG00000277632; ENSG00000274221
	n/a
	P10147
	n/a
	NM_002983
	n/a
	NP_002974
	n/a
	Wikidata
View/Edit Human