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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/14 02:10:50」(JST)

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Chemokine (C-C motif) ligand 27 (CCL27) is a small cytokine belonging to the CC chemokine family also known under the names IL-11 R-alpha-locus chemokine (ILC), Skinkine, ESkine and Cutaneous T-cell-attracting chemokine (CTACK). It is associated with homing of memory T lymphocytes to the skin, and plays a role in T cell-mediated inflammation of the skin.^[1]^[2] CCL27 is expressed in numerous tissues, including gonads, thymus, placenta and skin. It elicits its chemotactic effects by binding to the chemokine receptor CCR10.^[3] The gene for CCL27 is located on human chromosome 9.^[4]

References

^ Morales et al. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. U.S.A. 96:14470-14475, 1999.
^ Homey et al. CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nature Med. 8: 157-165, 2002.
^ Homey et al. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J. Immunol. 164:3465-3470, 2000.
^ Ishikawa-Mochizuki et al. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. FEBS Lett. 460:544-548, 1999.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

English Journal

Immune-mediated Skin Inflammation is Similar in Severe Atopic Dermatitis Patients With or Without Filaggrin Mutation.

Dajnoki Z1, Béke G, Mócsai G, Kapitány A, Gáspár K, Hajdu K, Emri G, Nagy B, Kovács I, Beke L, Dezső B, Szegedi A.
Acta dermato-venereologica.Acta Derm Venereol.2015 Nov 5. doi: 10.2340/00015555-2272. [Epub ahead of print]
Inflammatory cytokines can impair the skin barrier, but the question as to whether barrier alterations affect keratinocyte immune responses remains unanswered. The aim of this study was to investigate whether immune-mediated skin inflammation differs between severe atopic dermatitis patients with or
PMID 26536977

The Role of Chemokines in Mesenchymal Stem Cell Homing to Wounds.

Hocking AM1.
Advances in wound care.Adv Wound Care (New Rochelle).2015 Nov 1;4(11):623-630.
Significance: Mesenchymal stem cells (MSCs) are being administered to cutaneous wounds with the goal of accelerating wound closure and promoting regeneration instead of scar formation. An ongoing challenge for cell-based therapies is achieving effective and optimal targeted delivery and engraftment
PMID 26543676

Serum cytokine and chemokine profiles in patients with alopecia areata.

Bilgic O1, Sivrikaya A2, Unlu A2, Altinyazar HC1.
The Journal of dermatological treatment.J Dermatolog Treat.2015 Oct 7:1-4. [Epub ahead of print]
BACKGROUND: Most evidence supports the role of altered T cell-mediated immunity in the pathogenesis of alopecia areata (AA). Tough cytokines and chemokines play an important role in the immune process of AA, their expressions have been examined in limited studies.OBJECTIVE: To determine serum cytoki
PMID 26367497

Japanese Journal

皮膚のリンパ腫とケモカイン

日本臨床免疫学会会誌 = Japanese journal of clinical immunology 34(2), 91-98, 2011-04-28
NAID 10029431944

油症認定患者における血清ケモカイン濃度に関する研究 (油症とPCB及びダイオキシン関連化合物に関する研究報告集(第23集))

福岡医学雑誌 102(4), 105-108, 2011-04-25
NAID 40018966695

Chemokines and cutaneous lymphoma

Journal of dermatological science 59(2), 81-85, 2010-08-01
NAID 10027401703

Related Pictures

★リンクテーブル★

リンク元	「CTAK」
関連記事	「CCL」

「CTAK」

chemokine (C-C motif) ligand 27
Identifiers
Symbol	CCL27
Alt. symbols	SCYA27, ALP, ILC, CTACK, skinkine, ESkine, PESKY, CTAK
Entrez	10850
HUGO	10626
OMIM	604833
RefSeq	NM_006664
UniProt	Q9Y4X3
Other data
Locus	Chr. 9 q13