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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/01 10:48:46」(JST)

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C-C motif chemokine 19 is a protein that in humans is encoded by the CCL19 gene.^[1]^[2]

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7.^[2]

Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen.^[3] The gene for CCL19 is located on human chromosome 9.^[4] This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7.^[3] It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells,^[5]^[6] CCR7+ central-memory T-Cells.^[7]

References

^ Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J Biol Chem 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
^ ^a ^b "Entrez Gene: CCL19 chemokine (C-C motif) ligand 19". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6363.
^ ^a ^b Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J. Biol. Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.
^ Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. PMID 9013939. http://www.jimmunol.org/cgi/content/abstract/158/3/1033.
^ Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000). "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes". Cell 103 (5): 757–68. doi:10.1016/S0092-8674(00)00179-3. PMID 11114332.
^ Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). "Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position". Nature 416 (6876): 94–9. doi:10.1038/416094a. PMID 11882900.
^ Bromley SK, Thomas SY, Luster AD (2005). "Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics". Nat. Immunol. 6 (9): 895–901. doi:10.1038/ni1240. PMID 16116469.

English Journal

Inflammatory cytokine and chemokine expression in sympathetic ophthalmia: a pilot study.

Furusato E, Shen D, Cao X, Furusato B, Nussenblatt RB, Rushing EJ, Chan CC.SourceImmunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Washington, DC, USA.
Histology and histopathology.Histol Histopathol.2011 Sep;26(9):1145-51.
Sympathetic ophthalmia is a bilateral uveitis that develops after penetrating injury to one eye. This study aimed to identify the inflammatory cellular sub-phenotypes and expression of pertinent inflammatory cytokines/chemokines in sympathetic ophthalmia (SO). Dalen-Fuchs nodules (DFN), granulomas,
PMID 21751146

Seminal Fluid Regulates Accumulation of FOXP3+ Regulatory T Cells in the Preimplantation Mouse Uterus Through Expanding the FOXP3+ Cell Pool and CCL19-Mediated Recruitment.

Guerin LR, Moldenhauer LM, Prins JR, Bromfield JJ, Hayball JD, Robertson SA.SourceResearch Centre for Reproductive Health, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia.
Biology of reproduction.Biol Reprod.2011 Aug;85(2):397-408. Epub 2011 Mar 9.
Regulatory T (Treg) cells facilitate maternal immune tolerance of the semiallogeneic conceptus in early pregnancy, but the origin and regulation of these cells at embryo implantation is unclear. During the preimplantation period, factors in the seminal fluid delivered at coitus cause expansion of a
PMID 21389340

Japanese Journal

卵巣癌腹膜播種の新生血管を標的としてCCL19遺伝子導入胚性血管内皮前駆細胞を用いて局所免疫賦活を目指した新規免疫療法開発の基礎的検討(優秀論文賞受賞講演,<特集>第62回日本産科婦人科学会・学術講演会)

濱西潤三
日本産科婦人科學會雜誌 62(12), 2416-2423, 2010-12-01
NAID 110007989276

Altered antibody production and helper T cell function in mice lacking chemokines CCL19 and CCL21-Ser

Aritomi Kentaro,Kuwabara Taku,Tanaka Yuriko [他]
Microbiology and immunology 54(11), 691-701, 2010-11
NAID 40017367515

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リンク元	「MIP-3β」
関連記事	「CCL」

「MIP-3β」

Chemokine (C-C motif) ligand 19
Identifiers
Symbols	CCL19; CKb11; ELC; MIP-3b; MIP3B; SCYA19
External IDs	OMIM: 602227 MGI: 1346316 HomoloGene: 4569 GeneCards: CCL19 Gene
Gene Ontology
Molecular function	• chemokine activity; • CCR7 chemokine receptor binding; • CCR10 chemokine receptor binding; • CCR chemokine receptor binding;
Cellular component	• extracellular region; • extracellular space;
Biological process	• establishment of T cell polarity; • immunological synapse formation; • dendritic cell chemotaxis; • myeloid dendritic cell chemotaxis; • positive regulation of dendritic cell antigen processing and presentation; • cellular calcium ion homeostasis; • inflammatory response; • immune response; • cell communication; • activation of JUN kinase activity; • response to virus; • positive regulation of glycoprotein biosynthetic process; • response to organic cyclic compound; • T cell costimulation; • positive regulation of Ras GTPase activity; • positive regulation of interleukin-12 production; • positive regulation of tumor necrosis factor production; • response to prostaglandin E stimulus; • positive regulation of T cell proliferation; • positive regulation of NF-kappaB import into nucleus; • positive regulation of Cdc42 GTPase activity; • positive regulation of I-kappaB kinase/NF-kappaB cascade; • positive regulation of phosphatidylinositol 3-kinase activity; • positive regulation of T-helper 1 cell differentiation; • positive regulation of endocytosis; • positive regulation of protein kinase activity; • positive regulation of JNK cascade; • positive regulation of receptor-mediated endocytosis; • cell maturation; • positive regulation of interleukin-1 beta secretion; • positive regulation of chemotaxis; • release of sequestered calcium ion into cytosol; • positive regulation of protein kinase B signaling cascade; • regulation of cell projection assembly; • positive regulation of ERK1 and ERK2 cascade; • response to nitric oxide; • interleukin-12 secretion; • positive regulation of neutrophil chemotaxis; • mature dendritic cell differentiation; • negative regulation of leukocyte apoptotic process; • positive regulation of cell motility; • positive regulation of dendritic cell dendrite assembly;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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英: [[]]
関: CCL19

関: CCL19

「CCL」

　　[★] セファクロル cefaclor

[pmid9153236-0] Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J Biol Chem 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.

[entrez-1] "Entrez Gene: CCL19 chemokine (C-C motif) ligand 19". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6363.

[Yoshida_1997-2] Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997). "Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7". J. Biol. Chem. 272 (21): 13803–9. doi:10.1074/jbc.272.21.13803. PMID 9153236.

[pmid9013939-3] Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997). "Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta". J. Immunol. 158 (3): 1033–6. PMID 9013939. http://www.jimmunol.org/cgi/content/abstract/158/3/1033.

[pmid11114332-4] Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000). "The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes". Cell 103 (5): 757–68. doi:10.1016/S0092-8674(00)00179-3. PMID 11114332.

[pmid11882900-5] Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). "Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position". Nature 416 (6876): 94–9. doi:10.1038/416094a. PMID 11882900.

[pmid16116469-6] Bromley SK, Thomas SY, Luster AD (2005). "Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics". Nat. Immunol. 6 (9): 895–901. doi:10.1038/ni1240. PMID 16116469.

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CCL19