Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/06/11 06:27:48」(JST)

wiki en

Chemokine (C-C motif) ligand 18 (CCL18) is a small cytokine belonging to the CC chemokine family that was previously called PARC (pulmonary and activation-regulated chemokine). CCL18 is approximately 60% identical in amino acid sequence to CCL3. It is expressed at high levels in lung and at lower levels in certain lymphoid tissues, such as the lymph nodes, and is chemotactic for activated T cells and nonactivated lymphocytes.^[1] The gene for human CCL18 contains three exons and is located on chromosome 17.^[1]^[2]

References[edit]

^ ^a ^b Hieshima k, I. T. (August 1997). "A novel human CC chemokine PARC that is most homologous to macrophage-inflammatory protein-1 alpha/LD78 alpha and chemotactic for T lymphocytes, but not for monocytes". Journal of Immunology 159 (3): 1140–1149. PMID 9233607. edit
^ Tasaki, Y.; Fukuda, S.; Iio, M.; Miura, R.; Imai, T.; Sugano, S.; Yoshie, O.; Hughes, A. et al. (1999). "Chemokine PARC Gene (SCYA18) Generated by Fusion of Two MIP-1α/LD78α-like Genes, ,". Genomics 55 (3): 353–357. doi:10.1006/geno.1998.5670. PMID 10049593. |displayauthors= suggested (help) edit

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ゴーシェ病：初期評価、モニタリング、および臨床経過 gaucher disease initial assessment monitoring and clinical course
2. 全身性硬化症（強皮症）における間質性肺疾患の臨床症状、評価、および診断 clinical manifestations evaluation and diagnosis of interstitial lung disease in systemic sclerosis scleroderma
3. ウィップル病 whipples disease

English Journal

Global chemokine expression in systemic sclerosis (SSc): CCL19 expression correlates with vascular inflammation in SSc skin.

Mathes AL, Christmann RB, Stifano G, Affandi AJ, Radstake TR, Farina GA, Padilla C, McLaughlin S, Lafyatis R.SourceRheumatology Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Annals of the rheumatic diseases.Ann Rheum Dis.2013 Jul 19. doi: 10.1136/annrheumdis-2012-202814. [Epub ahead of print]
OBJECTIVE: To characterise global chemokine expression in systemic sclerosis (SSc) skin in order to better understand the relationship between chemokine expression and vascular inflammation in this disease.METHODS: We investigated chemokine mRNA expression in the skin through quantitative PCR analys
PMID 23873879

The Activity of CCL18 is Principally Mediated through Interaction with Glycosaminoglycans.

Krohn S, Garin A, Gabay C, Proudfoot AE.SourceDepartment of Immunology, Merck Serono Geneva Research Centre , Geneva , Switzerland.
Frontiers in immunology.Front Immunol.2013 Jul 15;4:193. doi: 10.3389/fimmu.2013.00193. Print 2013.
The CC chemokine ligand 18 (CCL18) was first identified as a chemoattractant for naïve T cells. It has been reported to recruit T and B lymphocytes, and we show here, natural killer (NK) cells, but with low efficacy. Investigation of its ability to elicit G-protein-coupled signaling showed that it
PMID 23874339

CCL18 in serum, BAL fluid and alveolar macrophage culture supernatant in interstitial lung diseases.

Cai M, Bonella F, He X, Sixt SU, Sarria R, Guzman J, Costabel U.SourceDepartment of Pneumology and Allergology, Ruhrlandklinik, University Hospital, University Duisburg-Essen, Tueschener Weg 40, D-45239 Essen, Germany; The 3rd Department of Infectious Disease Center, Beijing You-An Hospital, Capital Medical University, 100069 Beijing, China.
Respiratory medicine.Respir Med.2013 Jul 4. pii: S0954-6111(13)00216-3. doi: 10.1016/j.rmed.2013.06.004. [Epub ahead of print]
BACKGROUND: CCL18 is a CC chemokine produced mainly by antigen-presenting cells, and is chemotactic predominantly for T-lymphocytes. CCL18 can stimulate pulmonary fibroblasts and increase the collagen production in vitro.OBJECTIVES: This study aimed to compare the CCL18 levels in a variety of human
PMID 23831213

Japanese Journal

Identification of Genes Involved in the Suppression of Antibody Production from Human Peripheral Blood Lymphocytes

AIBA Yoshihiro,YAMASHITA Makiko,KATAKURA Yoshinori,FURUKAWA Yuki,MATSUMOTO Shin-ei,TOMIMATSU Kousuke,TERUYA Kiichiro,SHIRAHATA Sanetaka
Bioscience, biotechnology, and biochemistry 70(4), 966-970, 2006-04-23
… Among these genes, the expression of heavy chain ferritin (H-ferritin), CC chemokine ligand 18 (CCL18), and matrix metalloproteinase 12 (MMP12) were augmented in LLME-nontreated PBMCs, suggesting that inflammatory factors might be involved in the suppression of antibody production in LLME-nontreated PBMCs. …
NAID 10018532618

Plasma chitotriosidase and CCL 18 : Early biochemical surrogate markers in type B Niemann-Pick disease

BRINKMAN J
J Inherit Metab Dis 28, 13-20, 2005
NAID 30012219463

Related Pictures

★リンクテーブル★

リンク元	「DC-CK」
関連記事	「CCL」

「DC-CK」

chemokine (C-C motif) ligand 18
Identifiers
Symbol	CCL18
Alt. symbols	SCYA18, DC-CK1, PARC, AMAC-1, DCCK1, MIP-4, CKb7
Entrez	6362
HUGO	10616
OMIM	603757
RefSeq	NM_002988
UniProt	P55774
Other data
Locus	Chr. 17 q11.2