アンテナペディアホメオドメインタンパク質
- 関
- Antennapedia protein
WordNet
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
PrepTutorEJDIC
- 蛋白(たんばく)質
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/08/21 20:01:54」(JST)
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The mutation
Antennapedia
Antennapedia is a HOM-C gene first discovered in Drosophila which controls the formation of legs during development. Loss-of-function mutations in the regulatory region of this gene result in the development of the second leg pair into ectopic antennae. By contrast gain-of-function alleles convert antennae into ectopic legs.
This is just one illustration of the tendency of organisms to exhibit variations on a theme, modulated repetition. Legs and antennae are related to one another as much as molars are to incisors, fingers are to toes, and arms are to legs.
Antennapedia also refers to a gene complex in Drosophila which is responsible for formation and differentiation of the thoracic and head segments of the fly's body.
References[edit source | edit]
External links[edit source | edit]
- Antennapedia Homeodomain Protein at the US National Library of Medicine Medical Subject Headings (MeSH)
- Drosophila Antennapedia - The Interactive Fly
UpToDate Contents
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English Journal
- Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repression.
- Papadopoulos DK, Resendez-Perez D, Cardenas-Chavez DL, Villanueva-Segura K, Canales-del-Castillo R, Felix DA, Funfschilling R, Gehring WJ.SourceDepartment of Cell Biology, Biozentrum, University of Basel, 4056 Basel, Switzerland.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2011 Jul 19;108(29):11959-64. Epub 2011 Jun 28.
- Segmental identity along the anteroposterior axis of bilateral animals is specified by Hox genes. These genes encode transcription factors, harboring the conserved homeodomain and, generally, a YPWM motif, which binds Hox cofactors and increases Hox transcriptional specificity in vivo. Here we deriv
- PMID 21712439
- Targeting TLR4 signaling by TLR4 Toll/IL-1 receptor domain-derived decoy peptides: identification of the TLR4 Toll/IL-1 receptor domain dimerization interface.
- Toshchakov VY, Szmacinski H, Couture LA, Lakowicz JR, Vogel SN.SourceDepartment of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA. vtoshchakov@som.umaryland.edu
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2011 Apr 15;186(8):4819-27. Epub 2011 Mar 14.
- Agonist-induced dimerization of TLR4 Toll/IL-1R (TIR) domains initiates intracellular signaling. Therefore, identification of the TLR4-TIR dimerization interface is one key to the rational design of therapeutics that block TLR4 signaling. A library of cell-permeating decoy peptides, each of which re
- PMID 21402890
Japanese Journal
- Protein transduction technology: a novel therapeutic perspective.
- Noguchi Hirofumi,Matsumoto Shinichi
- Acta Medica Okayama 60(1), 1-11, 2006-02
- … During the past 15 years, a variety of peptides called protein transduction domains (PTDs) or cell penetrating peptides (CPPs), have been characterized for their ability to translocate into live cells. … The most commonly studied are homeodomain transcription factors such as Antennapedia, the herpes simplex virus (HSV) type 1 protein VP22, and the human immunodeficiency virus (HIV-1) transactivator TAT protein. …
- NAID 120002305662
Related Links
- The antennapedia homeodomain is a sequence-specific transcription factor from the organism Drosophila melanogaster. This protein is encoded by the Antennapedia (antp) gene. However, the antennapedia homeodomain (Antp) shown here ...
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- Antennapedia homeodomain protein
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- アンテナペディアタンパク質
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- Antennapedia homeodomain protein
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- homeoprotein