WordNet

natural bases containing nitrogen found in plants
snowdrop; narcissus; daffodil; in some classification systems considered a subfamily of the Liliaceae (同)family Amaryllidaceae, amaryllis family

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アルカロイド(植物に含まれる窒素を含む塩基性物質)

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1. デスモイド腫瘍：全身療法desmoid tumors systemic therapy [show details]
…the combination of methotrexate and a vinca alkaloid, although there is no evidence that combined therapy is better than either methotrexate or a vinca alkaloid alone. As a result, some clinicians favor …
2. マイトマイシン-Cの肺毒性mitomycin c pulmonary toxicity [show details]
…MMC plus a vinca alkaloid, and symptoms were temporally related to the administration of the vinca alkaloid. However, because there are no reports in which treatment with vinca alkaloids alone produced pulmonary …
3. 小児における有毒植物の誤飲：臨床症状および評価potentially toxic plant ingestions in children clinical manifestations and evaluation [show details]
… Toxic plants contain numerous chemical components including toxic alkaloids,… The most common of these toxic plants include: Bulbs of the Amaryllidaceae family (narcissus,…
4. ハーブ剤および栄養補助食品による肝毒性hepatotoxicity due to herbal medications and dietary supplements [show details]
…supplements developed by the National Institutes of Health . Pyrrolizidine alkaloids (PAs) are a group of naturally occurring alkaloids based on the structure of pyrrolizidine. More than 660 PAs and PA N-oxides …
5. ストリキニーネ中毒strychnine poisoning [show details]
… Strychnine, an alkaloid derived from seeds of the tree Strychnos nux vomica, was first used as a rodenticide in Germany in the early 16^th century. By the early 1900s, strychnine became widely available …

English Journal

Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer.

Hu M1, Peng S1, He Y1, Qin M1, Cong X1, Xing Y1, Liu M1,2, Yi Z1.
Oncotarget.Oncotarget.2015 Apr 12. [Epub ahead of print]
Lycorine, a natural alkaloid extracted from the Amaryllidaceae plant family, has been reported to exhibit a wide range of physiological effects, including the potential effect against cancer. However, the anti-prostate cancer (PCa) efficacy of Lycorine remains unrevealed. In this context, we figured
PMID 25915156

Jonquailine, a new pretazettine-type alkaloid isolated from Narcissus jonquilla quail, with activity against drug-resistant cancer.

Masi M1, Frolova LV2, Yu X3, Mathieu V4, Cimmino A1, De Carvalho A4, Kiss R4, Rogelj S2, Pertsemlidis A3, Kornienko A5, Evidente A6.
Fitoterapia.Fitoterapia.2015 Apr;102:41-8. doi: 10.1016/j.fitote.2015.01.009. Epub 2015 Jan 16.
A new alkaloid, belonging to the pretazettine group of Amaryllidaceae alkaloids, was isolated from dried bulbs of Narcissus jonquilla quail and named jonquailine. Its structure, including the absolute configuration, was elucidated using various NMR, ECD and ESI MS techniques. Initial biological eval
PMID 25598189

Concise total syntheses of (±)-mesembrane and (±)-crinane.

Das MK1, De S, Shubhashish, Bisai A.
Organic & biomolecular chemistry.Org Biomol Chem.2015 Mar 28;13(12):3585-8. doi: 10.1039/c5ob00183h.
A straightforward and unified strategy to access Amaryllidaceae alkaloids comprising a cis-3a-aryloctahydroindole scaffold has been developed. The strategy features Eschenmoser-Claisen rearrangement of allylalcohol as a key step for the installation of all-carbon quaternary stereocenters present in
PMID 25698179