Actinobacillus suis

アクチノバチルス・スイス

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/25 02:12:52」(JST)

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Actinobacillus suis
Actinobacillus suis
Scientific classification
Kingdom:	Bacteria
Phylum:	Proteobacteria
Class:	Gammaproteobacteria
Order:	Pasteurellales
Family:	Pasteurellaceae
Genus:	Actinobacillus Brumpt 1910
Species:	Actinobacillus suis

Actinobacillus suis is a beta-haemolytic, Gram-negative bacterium of the Pasteurellaceae family.

The bacterium has many strains and is the pathogen responsible for Actinobacillosis in pigs of all ages. It can also infect wild birds, domestic ruminants, dogs, cats and horses.

The organism can be found in the respiratory tract and tonsils of both infected and healthy pigs that act as carriers. Transmission is via the respiratory tract and piglets are usually infected early on in life.

Herds with a high health status are more at risk and outbreaks can be explosive.

Clinical Signs and Diagnosis

Affected piglets can develop septicaemia, multifocal infections, respiratory signs, and may die.

Adult pigs may show signs relating to pneumonia, lethargy, anorexia, skin lesions similar to Erysipelas and sudden death.

Diagnosis relies on the culture of sampled tissues to isolate the organism.

Signs and necropsy findings may mimic diseases such as: Erysipelas, Glasser's Disease, Streptococcus suis and Actinobacillus pleuropneumoniae.

Treatment and control

Antibiotics such as ceftiofur, gentamicin and trimethoprim/sulfadiazine are effective in treating the disease if diagnosis is rapid enough.

Biosecurity measures should be strictly followed in herds, including adequate quarantine time, testing and disinfection protocols.

References

• Actinobacillus suis, reviewed and published by Wikivet at http://en.wikivet.net/Actinobacillus_suis accessed 07/10/2011.

• Actinobacillosis - Pig, reviewed and published by Wikivet at http://en.wikivet.net/Actinobacillosis_-_Pig accessed 07/10/2011.

UpToDate Contents

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• 1. 歯性感染症の疫学、病因、および臨床症状 epidemiology pathogenesis and clinical manifestations of odontogenic infections
• 2. 頚部顔面の放線菌症 cervicofacial actinomycosis
• 3. 歯性感染症の合併症、診断、および治療 complications diagnosis and treatment of odontogenic infections
• 4. 感染性心内膜炎の疫学、危険因子および微生物学 epidemiology risk factors and microbiology of infective endocarditis
• 5. 培養陰性感染性心内膜炎の疫学、微生物学、および診断 epidemiology microbiology and diagnosis of culture negative endocarditis

English Journal

• Erythema Multiforme Associated with Respiratory Disease in a Commercial Breeding Pig Herd.

• Papatsiros VG1, Athanasiou LV1, Psalla D2, Petridou E3, Maragkakis GG1, Papatsas I4, Arsenakis I5, Maes D5.
• Viral immunology.Viral Immunol.2015 Aug 12. [Epub ahead of print]
• This study describes an erythema multiforme (EM) in breeding sows, after their mixing in the group housing system. Sows at 30-35 days of gestation showed red and raised skin areas, depression, anorexia, fever, respiratory problems, and increased return to estrus. Blood and nasal samples from disease
• PMID 26266696

• Sequence and structural diversity of transferrin receptors in Gram-negative porcine pathogens.

• Curran DM1, Adamiak PJ2, Fegan JE3, Qian C4, Yu RH5, Schryvers AB6.
• Vaccine.Vaccine.2015 Aug 8. pii: S0264-410X(15)01101-9. doi: 10.1016/j.vaccine.2015.07.097. [Epub ahead of print]
• Actinobacillus pleuropneumoniae, Actinobacillus suis, and Haemophilus parasuis are bacterial pathogens from the upper respiratory tract that are responsible for a substantial burden of porcine disease. Although reduction of disease has been accomplished by intensive management practices, immunizatio
• PMID 26263196

• First Human Case of Meningitis and Sepsis in a Child Caused by Actinobacillus suis or Actinobacillus equuli.

• Montagnani C1, Pecile P2, Moriondo M1, Petricci P3, Becciani S1, Chiappini E1, Indolfi G4, Rossolini GM5, Azzari C1, de Martino M1, Galli L6.
• Journal of clinical microbiology.J Clin Microbiol.2015 Jun;53(6):1990-2. doi: 10.1128/JCM.00339-15. Epub 2015 Apr 15.
• We report the first human case of meningitis and sepsis caused in a child by Actinobacillus suis or A. equuli, a common opportunistic pathogen of swine or horses, respectively. Identification was performed by matrix-assisted laser desorption ionization-time of flight mass spectrometry and real-time
• PMID 25878346

Japanese Journal

• 豚の全身性 Actinobacillus suis 感染症

• 佐々木 羊介,KABALI Emmanuel,芝原 友幸,小林 秀樹,清水 稚恵,森田 大輔,久保 正法
• 日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 64(5), 381-384, 2011-05-20
• NAID 10029384030

• Inactivated Actinobacillus suis in Synergy with Interferon-α Protects Mice against Herpes Simplex Virus-2 Infection

• WATANABE Takashi,SUZUKI Ikukatsu,HOTTA Chizuko,YOKOKURA Teruo
• Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 4(2), 76-82, 1998-06-01
• NAID 10009092209

Related Links

• Actinobacillus suis - Wikipedia, the free encyclopedia

Actinobacillus suis is a beta-haemolytic, Gram-negative bacterium of the Pasteurellaceae family. The bacterium has many strains and is the pathogen responsible for Actinobacillosis in pigs of all ages. It can also infect wild birds, domestic ...

• Actinobacillus suis | Iowa State University

In the 1980s, after management techniques were introduced that minimized exposure of neonates to many endemic pathogens, the incidence of Actinobacillus suis infections appeared to increase in the US industry. Misdiagnosis of the ...

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