English Journal

The role of individual protein kinase C isoforms in mouse mast cell function and their targeting by the immunomodulatory parasitic worm product, ES-62.

Bell KS1, Al-Riyami L1, Lumb FE1, Britton GJ2, Poole AW2, Williams CM2, Braun U3, Leitges M3, Harnett MM4, Harnett W5.
Immunology letters.Immunol Lett.2015 Sep 3;168(1):31-40. doi: 10.1016/j.imlet.2015.09.001. [Epub ahead of print]
ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, has been shown to modulate the immune system through subversion of signal transduction pathways operating in various immune system cells. With respect to human bone marrow-derived mast cells (BMMCs), ES-62 was previous
PMID 26343793

Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus.

Rodgers DT1, Pineda MA1, Suckling CJ2, Harnett W3, Harnett MM4.
Lupus.Lupus.2015 Jun 17. pii: 0961203315591031. [Epub ahead of print]
INTRODUCTION: ES-62, a phosphorylcholine (PC)-containing immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, protects against nephritis in the MRL/Lpr mouse model of systemic lupus erythematosus (SLE). However, ES-62 is not suitable for development as a therapy and thus we have
PMID 26085597

Siwila J1, Mwase ET2, Nejsum P3, Simonsen PE4.
Veterinary parasitology.Vet Parasitol.2015 Jun 15;210(3-4):250-4. doi: 10.1016/j.vetpar.2015.04.009. Epub 2015 Apr 23.
Filariae are common parasites of dogs in many parts of the world, but little is known about the status of these infections in sub-Saharan Africa. A study was carried out to determine the occurrence and species of filariae among 272 dogs in Lusaka, Zambia. Giemsa stained blood smear and Knott's conce
PMID 25944406

Japanese Journal

Nitric oxide synthase in filariae : Demonstration of nitric oxide production by embryos in Brugia malayi and Acanthocheilonema viteae

Histochemical differentiation of Dirofilaria immitis, Dirofilaria repens and Acanthocheilonema dracunculoides microfilariae by staining with a commercial kit, Leucognost-SP^( !R)