Aβ42、アミロイドβ42

English Journal

Anti-Alzheimer Therapeutic Drugs Targeting γ-Secretase.

Tan Y, Zhang Q, Wong SG, Hua Q1.
Current topics in medicinal chemistry.Curr Top Med Chem.2016;16(5):549-57.
γ-secretase is a membrane-embedded aspartyl protease carrying out cleavage of more than 100 single transmembrane-spanning proteins, including APP, Notch, N-cadherin, etc. Its subunit, presenilin (PS) is the catalytic component, of which mutations are a major cause of early onset familial Alzheimer
PMID 26268329

Yeast as a Model for Studies on Aβ Aggregation Toxicity in Alzheimer's Disease, Autophagic Responses, and Drug Screening.

Porzoor A1, Macreadie I.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1303:217-26. doi: 10.1007/978-1-4939-2627-5_12.
The Aβ peptide is widely considered a major cause of Alzheimer's disease since it causes neuronal death in an oligomerisation-dependent manner. In order to identify new inhibitors of Aβ that may be chemo preventative for Alzheimer's disease, a yeast assay that qualitatively determines the amounts
PMID 26235069

A study on the association between infectious burden and Alzheimer's disease.

Bu XL1, Yao XQ1, Jiao SS1, Zeng F1, Liu YH1, Xiang Y1, Liang CR1, Wang QH1, Wang X1, Cao HY1, Yi X1, Deng B1, Liu CH1, Xu J1, Zhang LL1, Gao CY1, Xu ZQ1, Zhang M1, Wang L1, Tan XL2, Xu X3, Zhou HD1, Wang YJ1.
European journal of neurology.Eur J Neurol.2015 Dec;22(12):1519-25. doi: 10.1111/ene.12477. Epub 2014 Jun 9.
BACKGROUND AND PURPOSE: Previous studies suggested that the overall burden of prior infections contributes to cardiovascular diseases and stroke. In the present study, the association between infectious burden (IB) and Alzheimer's disease (AD) was examined.METHODS: Antibody titers to common infectio
PMID 24910016

Japanese Journal

Synthesis and characterization of novel phenylindoles as potential probes for imaging of beta-amyloid plaques in the brain.

Bioorganic & medicinal chemistry 18(13), 4740-4746, 2010-05-13
NAID 120002353578

シンポジウム02―1　アカデミア発の創薬・治療研究　Aβ42Gene Vaccine for Prevention and Treatment of Alzheimer's Disease

臨床神経学 50(11), 838-838, 2010
NAID 130004504648

Synthesis and biological evaluation of radioiodinated 2,5-diphenyl-1,3,4-oxadiazoles for detecting beta-amyloid plaques in the brain.

Bioorganic & medicinal chemistry 17(17), 6402-6406, 2009-09-01
NAID 120002353577

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