AQP6

アクアポリン6 aquaporin 6

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/08/29 00:10:07」(JST)

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Aquaporin 6, kidney specific
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1S6E
Identifiers
Symbols	AQP6; AQP2L; KID
External IDs	OMIM: 601383 HomoloGene: 20399 IUPHAR: AQP6 GeneCards: AQP6 Gene
Gene Ontology Molecular function • anion channel activity • nitrate transmembrane transporter activity • water channel activity Cellular component • integral to plasma membrane • transport vesicle membrane Biological process • transport • water transport • excretion • odontogenesis • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	363	11831
Ensembl	ENSG00000086159	ENSMUSG00000043144
UniProt	Q13520	Q8C4A0
RefSeq (mRNA)	NM_001652.3	NM_175087.4
RefSeq (protein)	NP_001643.2	NP_780296.1
Location (UCSC)	Chr 12: 50.36 – 50.37 Mb	Chr 15: 99.6 – 99.61 Mb
PubMed search	[1]	[2]

Aquaporin 6, kidney specific is a protein in humans that is encoded by the AQP6 gene.

The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13.

References

Further Reading

• Ikeda, M.; Beitz, E.; Kozono, D.; Guggino, W. B.; Agre, P.; Yasui, M. (2002). "Characterization of Aquaporin-6 as a Nitrate Channel in Mammalian Cells. REQUIREMENT OF PORE-LINING RESIDUE THREONINE 63". Journal of Biological Chemistry 277 (42): 39873–39879. doi:10.1074/jbc.M207008200. PMID 12177001. 
• Ma, T.; Yang, B.; Umenishi, F.; Verkman, A. S. (1997). "Closely Spaced Tandem Arrangement of AQP2, AQP5, and AQP6 Genes in a 27-Kilobase Segment at Chromosome Locus 12q13". Genomics 43 (3): 387–389. doi:10.1006/geno.1997.4836. PMID 9268644. 
• Ishiyama, G.; Lopez, I. A.; Beltran-Parrazal, L.; Ishiyama, A. (2010). "Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma". Cell and Tissue Research 340 (3): 407–419. doi:10.1007/s00441-010-0975-7. PMC 2882038. PMID 20461409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882038. 
• Wang, W.; Hart, P. S.; Piesco, N. P.; Lu, X.; Gorry, M. C.; Hart, T. C. (2003). "Aquaporin Expression in Developing Human Teeth and Selected Orofacial Tissues". Calcified Tissue International 72 (3): 222–227. doi:10.1007/s00223-002-1014-9. PMID 12522663. 
• Yusenko, M. V.; Zubakov, D.; Kovacs, G. (2009). "Gene expression profiling of chromophobe renal cell carcinomas and renal oncocytomas by Affymetrix GeneChip using pooled and individual tumours". International journal of biological sciences 5 (6): 517–527. PMC 2726578. PMID 19680475. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2726578. 
• Ma, T.; Yang, B.; Kuo, W. L.; Verkman, A. S. (1996). "CDNA Cloning and Gene Structure of a Novel Water Channel Expressed Exclusively in Human Kidney: Evidence for a Gene Cluster of Aquaporins at Chromosome Locus 12q13". Genomics 35 (3): 543–550. doi:10.1006/geno.1996.0396. PMID 8812490. 

English Journal

• Meniere's disease: histopathology, cytochemistry, and imaging.

• Ishiyama G1, Lopez IA, Sepahdari AR, Ishiyama A.
• Annals of the New York Academy of Sciences.Ann N Y Acad Sci.2015 Apr;1343(1):49-57. doi: 10.1111/nyas.12699. Epub 2015 Mar 12.
• Meniere's disease is a poorly understood, disabling syndrome causing spells of vertigo, hearing fluctuation, tinnitus, and aural fullness. In this paper, we present a review of the histopathology, cytochemistry, and imaging of Meniere's disease. Histopathology is significant for neuroepithelial dama
• PMID 25766597

• Effects of estrogen deprivation on expression of aquaporins in rat vagina.

• Zhu J1, Xia J, Jiang J, Jiang R, He Y, Lin H.
• Menopause (New York, N.Y.).Menopause.2015 Jan 20. [Epub ahead of print]
• OBJECTIVE: This study aims to investigate the expression of aquaporin (AQP) 0, AQP3, AQP5, AQP6, AQP10, AQP11, and AQP12 in the vaginal tissue of ovariectomized rats.METHODS: Eight-week-old female Sprague-Dawley rats (n = 18) were randomly divided into three groups: control group (n = 6), ovariectom
• PMID 25608270

• Expression of adrenergic and cholinergic receptors in murine renal intercalated cells.

• Jun JG1, Maeda S, Kuwahara-Otani S, Tanaka K, Hayakawa T, Seki M.
• The Journal of veterinary medical science / the Japanese Society of Veterinary Science.J Vet Med Sci.2014 Nov;76(11):1493-500. Epub 2014 Jul 28.
• Neurons influence renal function and help to regulate fluid homeostasis, blood pressure and ion excretion. Intercalated cells (ICCs) are distributed throughout the renal collecting ducts and help regulate acid/base equilibration. Because ICCs are located among principal cells, it has been difficult
• PMID 25069412

Japanese Journal

• Expression of Adrenergic and Cholinergic Receptors in Murine Renal Intercalated Cells

• JUN Jin-Gon,MAEDA Seishi,KUWAHARA-OTANI Sachi,TANAKA Koichi,HAYAKAWA Tetsu,SEKI Makoto
• Journal of Veterinary Medical Science, 2014
• … Further, b2 receptor-positive cells in the murine cortical collecting ducts also express AQP6, indicating that these cells are ICCs. … Cells in the collecting ducts also express the m1 receptor protein, and some m1-positive cells express AQP6. … Interestingly, acetylcholinesterase-positive cells neighbored AQP6-positive cells, suggesting that principal cells may regulate the availability of acetylcholine. …
• NAID 130004677720

• Role of Aquaporin-6 in Rat Parotid Secretory Granules

• MATSUKI FUKUSHIMA Miwako,FUJITA YOSHIGAKI Junko,MURAKAMI Masataka,KATSUMATA KATO Osamu,SUGIYA Hiroshi
• Journal of oral biosciences 53(4), 312-317, 2011-11-20
• NAID 10030175468

• Role of Aquaporin-6 in Rat Parotid Secretory Granules

• Matsuki-Fukushima Miwako,Fujita-Yoshigaki Junko,Murakami Masataka,Katsumata-Kato Osamu,Sugiya Hiroshi
• Journal of Oral Biosciences 53(4), 312-317, 2011
• … Aquaporin-6 (AQP6) is a unique member of the family of AQP water channels and is involved in anion permeability. … AQP6 was initially discovered in the cytoplasm of kidney cells as a kidney-specific AQP; … however, subsequent studies revealed that the brain, inner ear, vestibular and intestines also express AQP6. … Recently, we demonstrated that reactivity with an AQP6 antibody was observed in rat parotid granule membranes using immunohistochemistry. …
• NAID 130004475751

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★リンクテーブル★

リンク元	「アクアポリン6」「aquaporin 6」
関連記事	「AQP」

「アクアポリン6」

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英

aquaporin 6、AQP6

関

アクア・リン-6

「aquaporin 6」

　　[★]

アクア・リン6

関

AQP6

「AQP」

　　[★] アクアポリン aquaporin