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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/05 10:41:30」(JST)

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Aquaporin-5 is a protein that in humans is encoded by the AQP5 gene.^[3]^[4]

Aquaporin 5 (AQP5) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 5 plays a role in the generation of saliva, tears and pulmonary secretions. AQP0, AQP2, AQP5, and AQP6 are closely related and all map to 12q13.^[4]

References

^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Lee MD, Bhakta KY, Raina S, Yonescu R, Griffin CA, Copeland NG, Gilbert DJ, Jenkins NA, Preston GM, Agre P (Jun 1996). "The human Aquaporin-5 gene. Molecular characterization and chromosomal localization". J Biol Chem. 271 (15): 8599–604. doi:10.1074/jbc.271.15.8599. PMID 8621489.
^ ^a ^b "Entrez Gene: AQP5 aquaporin 5".

External links

AQP5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 新生児の一過性頻呼吸 transient tachypnea of the newborn
2. 腹膜透析における溶質クリアランスおよび限外濾過の機序 mechanisms of solute clearance and ultrafiltration in peritoneal dialysis
3. シェーグレン症候群における口内乾燥およびその他の非眼結膜炎症状の治療 treatment of dry mouth and other non ocular sicca symptoms in sjogrens syndrome

English Journal

Cellular overexpression of Aquaporins slows down the natural HIF-2α degradation during prolonged hypoxia.

Galán-Cobo A, Sánchez-Silva R, Serna A, Abreu-Rodríguez I, Muñoz-Cabello AM, Echevarría M.SourceInstituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Departamento de Fisiología Médica y Biofísica, Seville, Spain.
Gene.Gene.2013 Jun 10;522(1):18-26. doi: 10.1016/j.gene.2013.03.075. Epub 2013 Mar 29.
Overexpression of cell membrane aquaporins (AQPs) has recently been associated with tumor formation, particularly with angiogenesis, cell migration and proliferation. Additionally, the hypoxia inducible factor (HIF) family has been extensively implicated in tumor growth and recent studies evidence i
PMID 23545307

Regulated traffic of anion transporters in mammalian Brunner's glands: a role for water and fluid transport.

Collaco AM, Jakab RL, Hoekstra N, Mitchell K, Brooks A, Ameen NA.Source1Yale University School of Medicine.
American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2013 Jun 6. [Epub ahead of print]
The Brunner's glands of the proximal duodenum exert barrier functions through secretion of glycoproteins and antimicrobial peptides. However, ion transporter localization, function, and regulation in the glands are less clear. Mapping the subcellular distribution of transporters is an important step
PMID 23744739

Mesenchymal stem cells protect against neonatal rat hyperoxic lung injury.

Zhang H, Fang J, Wu Y, Mai Y, Lai W, Su H.SourceSun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Department of Pediatric , Yanjiang Road 107, Guangzhou, Guangdong 510120 , China +86 20 13642640725 ; zhhosh@126.com.
Expert opinion on biological therapy.Expert Opin Biol Ther.2013 Jun;13(6):817-29. doi: 10.1517/14712598.2013.778969. Epub 2013 Mar 27.
Objectives: Bronchopulmonary dysplasia (BPD) is a significant global health problem and currently lacks effective therapy. We established a neonatal rat model of BPD to investigate therapeutic potential of bone marrow-derived mesenchymal stem cells (BMSCs) in neonatal hyperoxic lung injury. Methods:
PMID 23534609

Japanese Journal

肺腺癌の進展におけるアクアポリンの役割

町田雄一郎,上田善道,上野正克,田中良,相川広一,薄田勝男,佐川元保,佐久間勉
肺癌 52(1), 17-22, 2012
… 現と進展への関与に関する知見を紹介する．結果．肺癌ではAQP1，3，4，5が腺癌細胞に発現する．その発現は，1）細胞分化に相当する極性を有するAQP1，3の発現，2）極性は保たれるが正常肺では認められないAQP5の異所性発現，3）極性を喪失したAQP1，5の過剰発現に区分される．1）は細気管支肺胞上皮癌に高頻度で，進展に伴い減少する．2）は肺胞上皮癌のみならず異型腺腫様過形成でも見られ，腫瘍発生に関係して …
NAID 130002060207

Function of the Membrane Water Channel Aquaporin-5 in the Salivary Gland

Matsuzaki Toshiyuki,Susa Taketo,Shimizu Kinue,Sawai Nobuhiko,Suzuki Takeshi,Aoki Takeo,Yokoo Satoshi,Takata Kuniaki
ACTA HISTOCHEMICA ET CYTOCHEMICA 45(5), 251-259, 2012
… It is well known that aquaporin-5 (AQP5) is expressed in the salivary glands, in which it is mainly localized at the apical membrane of the acinar cells. … This suggests the physiological importance of AQP5 in transcellular water transfer. … Reduced saliva secretion under pilocarpine stimulation in AQP5-null mice compared with normal mice further indicates the importance of AQP5 in this process, at least in stimulated saliva secretion. …
NAID 130001854258

Autonomic Nerve-Regulated AQP5 Distribution in Salivary Glands and AQP5 Release into Saliva

WANG Di,ISHIKAWA Yasuko
Journal of oral biosciences 53(1), 38-47, 2011-02-20
NAID 10027793648

Related Pictures

Schematic diagram of mouse AQP5 transmembrane topology. NPA (blue | Download Defective channels lead to an impaired skin barrier | Journal of Cell Science AQP5 ELISA Kits | Biocompare.com AQP5: A novel biomarker that predicts poor clinical outcome in colorectal cancer Estrogen-induced Protein Found To Promote Endometrial Cell Growth at Ectopic Sites Impairment of TRPC1–STIM1 channel assembly and AQP5 translocation compromise agonist The expression of M3 receptor and AQP5. The mRNA expression of M3 | Download Role of aquaporins in saliva secretion.OA Biochemistry

★リンクテーブル★

リンク元	「アクアポリン5」「aquaporin 5」
関連記事	「AQP」

「アクアポリン5」

AQP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D9S, 5C5X, 5DYE
Identifiers
Aliases	AQP5, AQP-5, PPKB, aquaporin 5
External IDs	MGI: 106215 HomoloGene: 20398 GeneCards: AQP5
Gene ontology
Molecular function	• transporter activity; • protein binding; • water channel activity;
Cellular component	• integral component of membrane; • membrane; • plasma membrane; • integral component of plasma membrane; • microvillus; • basal plasma membrane; • apical plasma membrane; • endoplasmic reticulum; • extracellular exosome;
Biological process	• excretion; • water transport; • pancreatic juice secretion; • saliva secretion; • odontogenesis; • ion transmembrane transport; • transport; • camera-type eye morphogenesis; • carbon dioxide transport;
	Sources:Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	362
	11830
	ENSG00000161798
	ENSMUSG00000044217
	P55064
	Q9WTY4
	NM_001651
	NM_009701
	NP_001642
	NP_033831.1; NP_033831
	Wikidata
View/Edit Human	View/Edit Mouse