AKAP

• Aキナーゼアンカータンパク質

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A kinase anchor protein

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/27 20:43:37」(JST)

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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. At least 20 AKAPs have been cloned. There are at least 50 members, often named after their molecular mass.

• AKAP1
• AKAP2
• AKAP3
• AKAP4
• AKAP5
• AKAP6
• AKAP7
• AKAP8
• AKAP9
• AKAP10
• AKAP11
• AKAP12
• AKAP13

Function

AKAPs act as scaffold proteins wherein they bind PKA and other signaling proteins and physically tether these multi-protein complexes to specific locations, such as the nucleus, in cells. This allows specific targeting of substrates to be regulated by phosphorylation (by PKA) and dephosphorylation (by phosphatases). The dimerization and docking (D/D) domain of the regulatory subunit dimer of PKA binds with the A-kinase binding (AKB) domain (an amphipathic helix) of AKAP. The AKAPs also bind other components, including; phosphodiesterases (PDEs) which break down cAMP, phosphatases which dephosphorylate downstream PKA targets and also other kinases (PKC and MAPK). Some AKAPs are able to bind both regulatory subunits (RI & RII) of PKA and are dual-specific AKAPs (D-AKAP1 and D-AKAP2).

References

English Journal

• Interaction of PACAP with Sonic hedgehog reveals complex regulation of the Hedgehog pathway by PKA.

• Niewiadomski P, Zhujiang A, Youssef M, Waschek JA.SourceIntellectual Development and Disabilities Research Center, The David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, United States.
• Cellular signalling.Cell Signal.2013 Nov;25(11):2222-30. doi: 10.1016/j.cellsig.2013.07.012. Epub 2013 Jul 18.
• Sonic hedgehog (Shh) signaling is essential for proliferation of cerebellar granule cell progenitors (cGCPs) and its aberrant activation causes a cerebellar cancer medulloblastoma. Pituitary adenylate cyclase activating polypeptide (PACAP) inhibits Shh-driven proliferation of cGCPs and acts as tumor
• PMID 23872071

• Receptor-mediated Ca(2+) and PKC signaling triggers the loss of cortical PKA compartmentalization through the redistribution of gravin.

• Schott MB, Grove B.SourceDepartment of Basic Sciences, UND School of Medicine and Health Sciences, 501 N Columbia Rd., Grand Forks, ND, 58202-9037, United States.
• Cellular signalling.Cell Signal.2013 Nov;25(11):2125-35. doi: 10.1016/j.cellsig.2013.07.004. Epub 2013 Jul 6.
• A-Kinase Anchoring Proteins (AKAPs) direct the flow of cellular information by positioning multiprotein signaling complexes into proximity with effector proteins. However, certain AKAPs are not stationary but can undergo spatiotemporal redistribution in response to stimuli. Gravin, a 300kD AKAP that
• PMID 23838009

• AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex.

• Shen JX, Cooper DM.Source*Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, U.K.
• The Biochemical journal.Biochem J.2013 Oct 1;455(1):47-56. doi: 10.1042/BJ20130359.
• AC2 (adenylate cyclase 2) is stimulated by activation of Gq-coupled muscarinic receptors through PKC (protein kinase C) to generate localized cAMP in HEK (human embryonic kidney)-293 cells. In the present study, we utilized a sensitive live-cell imaging technique to unravel the proteins that play es
• PMID 23889134

Japanese Journal

• ブタ卵母細胞におけるA-kinase anchoring protein (AKAP) の発現と機能

• 西村 鷹則,藤井 渉,加納 聖,杉浦 幸二,内藤 邦彦
• Journal of mammalian ova research = 日本哺乳動物卵子学会誌 28(2), S43, 2011-04-01
• NAID 10028124333

• A regulatory SNP in AKAP13 is associated with blood pressure in Koreans

• Hong Kyung-Won,Lim Ji-Eun,Oh Bermseok
• Journal of human genetics 56(3), 205-210, 2011-03-01
• NAID 10030658297

• OP-253-1 肝細胞癌におけるA kinase anchor protein 12(AKAP12)遺伝子の発現について(肝基礎研究-3,一般口演,第110回日本外科学会定期学術集会)

• 林 真路,野本 周嗣,岡村 行泰,神田 光郎,藤井 努,杉本 博行,竹田 伸,中尾 昭公
• 日本外科学会雑誌 111(臨時増刊号_2), 676, 2010-03-05
• NAID 110007718220

Related Links

• akaPのプロフィール｜Ameba (アメーバ)

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• AKAP | Facebook

AKAP. 141 likes · 5 talking about this. "kabalikat sa pag-abot ng iyong mga pangarap" ... Jhoy Omigan hehehe bungad na bngad si sir jake December 10, 2013 at 3:27am Jeffrey Padillo Happy Birthday po Mam Lyn.. more blessings ...

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AKAP

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A kinase anchor protein、AKAP