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English Journal
- Progestin and antiprogestin responsiveness in breast cancer is driven by the PRA/PRB ratio via AIB1 or SMRT recruitment to the CCND1 and MYC promoters.
- Wargon V1, Riggio M, Giulianelli S, Sequeira GR, Rojas P, May M, Polo ML, Gorostiaga MA, Jacobsen B, Molinolo A, Novaro V, Lanari C.
- International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jun 1;136(11):2680-92. doi: 10.1002/ijc.29304. Epub 2014 Nov 12.
- There is emerging interest in understanding the role of progesterone receptors (PRs) in breast cancer. The aim of this study was to investigate the proliferative effect of progestins and antiprogestins depending on the relative expression of the A (PRA) and B (PRB) isoforms of PR. In mifepristone (M
- PMID 25363551
- Reprogramming of the ERRα and ERα target gene landscape triggers tamoxifen resistance in breast cancer.
- Thewes V1, Simon R2, Schroeter P1, Schlotter M1, Anzeneder T3, Büttner R4, Benes V5, Sauter G2, Burwinkel B6, Nicholson RI7, Sinn HP8, Schneeweiss A9, Deuschle U10, Zapatka M1, Heck S1, Lichter P11.
- Cancer research.Cancer Res.2015 Feb 15;75(4):720-31. doi: 10.1158/0008-5472.CAN-14-0652. Epub 2015 Feb 2.
- Endocrine treatment regimens for breast cancer that target the estrogen receptor-α (ERα) are effective, but acquired resistance remains a limiting drawback. One mechanism of acquired resistance that has been hypothesized is functional substitution of the orphan receptor estrogen-related receptor-�
- PMID 25643697
Japanese Journal
- The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome
- Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer
Related Links
- 1. Science. 1997 Aug 15;277(5328):965-8. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer ...
- Results AIB1 Mediates ERα Down-Regulation by E2. In an effort to delineate the link between ERα degradation and its transcriptional activity and to determine whether the coactivators, in addition to enhancing the ...
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