- 英
- [[]]
- 関
- [[]]
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/06/27 15:37:01」(JST)
[Wiki en表示]
| ADAM metallopeptidase domain 33 |
PDB rendering based on 1r54. |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
1R54, 1R55
|
|
|
| Identifiers |
| Symbols |
ADAM33; C20orf153; DJ964F7.1 |
| External IDs |
OMIM: 607114 MGI: 1341813 HomoloGene: 11881 ChEMBL: 6121 GeneCards: ADAM33 Gene |
| Gene Ontology |
| Molecular function |
• metalloendopeptidase activity
• metalloendopeptidase activity
• peptidase activity
• zinc ion binding
• zinc ion binding
• metal ion binding
|
| Cellular component |
• membrane
• integral to membrane
|
| Biological process |
• proteolysis
• proteolysis
• integrin-mediated signaling pathway
|
| Sources: Amigo / QuickGO |
|
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
80332 |
110751 |
|
| Ensembl |
ENSG00000149451 |
ENSMUSG00000027318 |
|
| UniProt |
Q9BZ11 |
Q923W9 |
|
| RefSeq (mRNA) |
NM_025220.2 |
NM_001163529.1 |
|
| RefSeq (protein) |
NP_079496.1 |
NP_001157001.1 |
|
| Location (UCSC) |
Chr 20:
3.65 – 3.66 Mb |
Chr 2:
130.88 – 130.89 Mb |
|
| PubMed search |
[1] |
[2] |
|
|
|
Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.[1][2]
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[2]
References
- ^ Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, Yoshino K, Ishiguro H, Higashiyama S (Jan 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene 282 (1–2): 227–36. DOI:10.1016/S0378-1119(01)00818-6. PMID 11814695.
- ^ a b "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80332.
Further reading
- Holgate ST, Davies DE, Rorke S et al. (2005). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical reviews in allergy & immunology 27 (1): 23–34. DOI:10.1385/CRIAI:27:1:023. PMID 15347848.
- Holloway JW, Davies DE, Powell R et al. (2007). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert reviews in molecular medicine 6 (17): 1–12. DOI:10.1017/S1462399404007963. PMID 15387895.
- Holgate ST, Yang Y, Haitchi HM et al. (2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society 3 (5): 440–3. DOI:10.1513/pats.200603-026AW. PMID 16799089.
- Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. DOI:10.1038/414865a. PMID 11780052.
- Van Eerdewegh P, Little RD, Dupuis J et al. (2002). "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness". Nature 418 (6896): 426–30. DOI:10.1038/nature00878. PMID 12110844.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Garlisi CG, Zou J, Devito KE et al. (2003). "Human ADAM33: protein maturation and localization". Biochem. Biophys. Res. Commun. 301 (1): 35–43. DOI:10.1016/S0006-291X(02)02976-5. PMID 12535637.
- Chae SC, Yoon KH, Chung HT (2003). "Identification of novel polymorphisms in the Adam33 gene". J. Hum. Genet. 48 (5): 278–81. DOI:10.1007/s10038-003-0019-1. PMID 12768445.
- Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. DOI:10.1101/gr.1293003. PMC 403697. PMID 12975309. //www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
- Howard TD, Postma DS, Jongepier H et al. (2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". J. Allergy Clin. Immunol. 112 (4): 717–22. DOI:10.1016/S0091. PMID 14564349.
- Orth P, Reichert P, Wang W et al. (2004). "Crystal structure of the catalytic domain of human ADAM33". J. Mol. Biol. 335 (1): 129–37. DOI:10.1016/j.jmb.2003.10.037. PMID 14659745.
- Zou J, Zhu F, Liu J et al. (2004). "Catalytic activity of human ADAM33". J. Biol. Chem. 279 (11): 9818–30. DOI:10.1074/jbc.M309696200. PMID 14676211.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
- Powell RM, Wicks J, Holloway JW et al. (2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". Am. J. Respir. Cell Mol. Biol. 31 (1): 13–21. DOI:10.1165/rcmb.2003-0330OC. PMID 14742294.
- Haitchi HM, Powell RM, Shaw TJ et al. (2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". Am. J. Respir. Crit. Care Med. 171 (9): 958–65. DOI:10.1164/rccm.200409-1251OC. PMID 15709049.
- Zou J, Zhang R, Zhu F et al. (2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry 44 (11): 4247–56. DOI:10.1021/bi0476230. PMID 15766253.
- Simpson A, Maniatis N, Jury F et al. (2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". Am. J. Respir. Crit. Care Med. 172 (1): 55–60. DOI:10.1164/rccm.200412-1708OC. PMID 15805180.
External links
- The MEROPS online database for peptidases and their inhibitors: M12.244
|
PDB gallery
|
|
|
|
|
1r54: Crystal structure of the catalytic domain of human ADAM33
|
|
|
|
1r55: Crystal structure of the catalytic domain of human ADAM 33
|
|
|
|
|
Proteases: metalloendopeptidases (EC 3.4.24)
|
|
| ADAM proteins |
Alpha secretases (ADAM9 · ADAM10 · ADAM17 · ADAM19) · ADAM2 · ADAM7 · ADAM8 · ADAM11 · ADAM12 · ADAM15 · ADAM18 · ADAM22 · ADAM23 · ADAM28 · ADAM33 · ADAMTS1 · ADAMTS2 · ADAMTS3 · ADAMTS4 · ADAMTS5 · ADAMTS8 · ADAMTS9 · ADAMTS10 · ADAMTS12 · ADAMTS13
|
|
| Matrix metalloproteinases |
Collagenases (MMP1, MMP8) · Gelatinases (MMP2, MMP9) · MMP3 · MMP7 · MMP10 · MMP11 · MMP12 · MMP13 · MMP14 · MMP15 · MMP16 · MMP17 · MMP19 · MMP20 · MMP21 · MMP23A · MMP23B · MMP24 · MMP25 · MMP26 · MMP27 · MMP28
|
|
| Other |
Neprilysin · Procollagen peptidase · Thermolysin · Pregnancy-associated plasma protein A · Bone morphogenetic protein 1 · Lysostaphin · Insulin degrading enzyme · ZMPSTE24
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 2.7.10
- 2.7.11-12
- 3.1
- 3.1.3.48
- 3.4.21
- 4.1
- 5.1
- 6.1-3
|
|
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: A meta-analysis.
- Liang S, Wei X, Gong C, Wei J, Chen Z, Deng J.SourceDepartment of Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
- Human immunology.Hum Immunol.2013 May;74(5):648-57. doi: 10.1016/j.humimm.2013.01.025. Epub 2013 Feb 1.
- Polymorphisms in the ADAM33 gene have been associated with asthma, but the data are controversial. Therefore, we reviewed the related studies and quantitatively summarized the associations between ADAM33 polymorphisms and asthma risk using meta-analysis. A dominant model (AA+Aa vs. aa), recessive mo
- PMID 23380143
- Possible control of paternal imprinting of polymorphisms of the ADAM33 gene by epigenetic mechanisms and association with level of airway hyperresponsiveness in asthmatic children.
- Kopriva F, Godava M, Markova M, Vodicka R, Dusek L, Muzik J, Schneiderova E, Vrtel R, Mihal V.SourceDepartment of Paediatrics, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic.
- Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub.2013 Apr 23. doi: 10.5507/bp.2013.025. [Epub ahead of print]
- INTRODUCTION: ADAM33 is the candidate gene most commonly associated with asthma and airway hyperreactivity (AHR).AIM: The aim of this study was to determine whether level of AHR is associated with certain alleles or haplotypes of the ADAM33 gene in asthmatic children.METHODS: One hundred and nine as
- PMID 23640030
- Association between ADAM33 S2 and ST+4 polymorphisms and susceptibility to asthma: A meta-analysis.
- Song GG, Kim JH, Lee YH.SourceDivision of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
- Gene.Gene.2013 Apr 21. pii: S0378-1119(13)00473-3. doi: 10.1016/j.gene.2013.04.023. [Epub ahead of print]
- OBJECTIVE: The aim of this study was to determine whether ADAM33 (a disintegrin and metalloproteinase domain 33) polymorphisms confer susceptibility to asthma in different populations.METHODS: We performed a meta-analysis on the association between the ADAM33 S2, ST+4, F+1, S1, and V4 polymorphisms
- PMID 23612257
Japanese Journal
- Association of ADAM33 gene polymorphisms with asthma in Indian children
- AWASTHI Shally,TRIPATHI Priya,GANESH Subramaniam,HUSAIN Nuzhat
- Journal of human genetics 56(3), 188-195, 2011-03-01
- NAID 10030658197
- Association of ADAM33 gene polymorphisms with asthma in Indian children
- Awasthi Shally,Tripathi Priya,Ganesh Subramaniam [他]
- Journal of human genetics 56(3), 188-195, 2011-03
- NAID 40018724193
Related Pictures
