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English Journal

Mitochondrial Permeability Transition Pore Component Cyclophilin D Distinguishes Nigrostriatal Dopaminergic Death Paradigms in the MPTP Mouse Model of Parkinson's Disease.

Thomas B, Banerjee R, Starkova NN, Zhang SF, Calingasan NY, Yang L, Wille E, Lorenzo BJ, Ho DJ, Beal MF, Starkov A.SourceDepartment of Neurology and Neuroscience, Weill Medical College of Cornell University , New York, New York.
Antioxidants & redox signaling.Antioxid Redox Signal.2012 May 1;16(9):855-68. Epub 2011 Jun 16.
Abstract Aims: Mitochondrial damage due to Ca(2+) overload-induced opening of permeability transition pores (PTP) is believed to play a role in selective degeneration of nigrostriatal dopaminergic neurons in Parkinson's disease (PD). Genetic ablation of mitochondrial matrix protein cyclophilin D (
PMID 21529244

Overexpression of TFAM, NRF-1 and myr-AKT protects the MPP(+)-induced mitochondrial dysfunctions in neuronal cells.

Piao Y, Kim HG, Oh MS, Pak YK.SourceNeurodegeneration Control Research Center, Department of Neuroscience, Department of Physiology, College of Medicine, South Korea.
Biochimica et biophysica acta.Biochim Biophys Acta.2012 May;1820(5):577-85. Epub 2011 Aug 11.
BACKGROUND: Mitochondrial dysfunction is a prominent feature of neurodegenerative diseases including Parkinson's disease (PD), in which insulin signaling pathway may also be implicated because 50-80% of PD patients exhibited metabolic syndrome and insulin resistance. 1-methyl-4-phenyl-1,2,3,6-tetrah
PMID 21856379

Therapeutic Effects of Multifunctional Tetramethylpyrazine Nitrone on Models of Parkinson's Disease in Vitro and in Vivo

Guo Baojian,Xu Daping,Duan Hongwei [他],Du Jing,Zhang Zaijun,Lee Simon MingYuen,Wang Yuqiang
Biological and Pharmaceutical Bulletin 37(2), 274-285, 2014
… 2-[[(1,1-Dimethylethyl)oxidoimino]-methyl]-3,5,6-trimethylpyrazine (TBN), a novel nitrone derivative of tetramethylpyrazine, has shown significant therapeutic effects in stroke models due to its multiple functions, including calcium overload blockade and free radical-scavenging. …
NAID 130003382123

Biochemical evaluation of the neurotoxicity of MPTP and MPP⁺ in embryonic and newborn mice

Sai Takafumi,Uchida Kazuyuki,Nakayama Hiroyuki
The Journal of toxicological sciences : an official journal of the Japanese Society of Toxicology 38(3), 445-458, 2013-06
NAID 40019756780

Changes of MAO-A and MAO-B Expressions in the Placenta of MPTP or MPP+ Treated Mice

Sai Takafumi,Uchida Kazuyuki,Nakayama Hiroyuki
Journal of Toxicologic Pathology 26(1), 73-77, 2013
… In the present study, we evaluated the influence of intraperitoneal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 1-methyl-4-phenylpyridinium (MPP+) on the placenta. … There was no increase in apoptotic cells in the placentas of C57BL/6 mice treated with 25.0 mg/kg MPTP or 17.1 mg/kg MPP+, indicating that a single injection of the chemicals may induce very slight cytotoxicity in the placenta at 12 hr after administration. …
NAID 130003362347