5-methylurapidil

English Journal

Simultaneous activation of the α1A-, α1B- and α1D-adrenoceptor subtypes in the nucleus accumbens reduces accumbal dopamine efflux in freely moving rats.

Aono Y1, Taguchi H, Saigusa T, Uchida T, Takada K, Takiguchi H, Shirakawa T, Shimizu N, Koshikawa N, Cools AR.
Behavioural pharmacology.Behav Pharmacol.2015 Feb;26(1-2):73-80. doi: 10.1097/FBP.0000000000000113.
Intra-accumbal infusion of the α1-adrenergic agonist methoxamine, which has comparable affinity for α1A-, α1B- and α1D-adrenoceptor subtypes, fails to alter noradrenaline efflux but reduces dopamine efflux in the nucleus accumbens of rats. In-vivo microdialysis experiments were carried out to an
PMID 25438092

Adrenergic regulation of the rapid component of delayed rectifier K+ currents in guinea pig cardiomyocytes.

Wang S1, Min XY1, Pang SS1, Qian J1, Xu D1, Guo Y1.
Journal of thoracic disease.J Thorac Dis.2014 Dec;6(12):1778-84. doi: 10.3978/j.issn.2072-1439.2014.12.27.
BACKGROUND: Guinea pig ventricular cardiomyocytes display the rapid component of the delayed rectifier potassium current (Ikr) that contributes to ventricular repolarization and promotes stress-induced arrhythmias. Adrenergic stimulation favors ventricular arrhythmogenesis but its effects on Ikr are
PMID 25589973

Pharmacological identification of α1- and α2-adrenoceptor subtypes involved in the vasopressor responses induced by ergotamine in pithed rats.

Villamil-Hernández MT1, Alcántara-Vázquez O, Sánchez-López A, Centurión D.
European journal of pharmacology.Eur J Pharmacol.2013 Sep 5;715(1-3):262-9. doi: 10.1016/j.ejphar.2013.05.011. Epub 2013 May 22.
Ergotamine has been used in clinical practice for the acute treatment of migraine for over 90 years. So far, it is known that ergotamine interacts with diverse receptors (including α1/2-adrenoceptors, 5-HT1, 5-HT2 and D2-like receptors) and that produces increases in mean blood pressure which are s
PMID 23707349

Affinity of Serotonin Receptor Antagonists and Agonists to Recombinant and Native α_2-Adrenoceptor Subtypes

YOSHIO Rika,TANIGUCHI Takanobu,ITOH Harumi,MURAMATSU Ikunobu
The Japanese journal of pharmacology 86(2), 189-195, 2001-06-01
… Binding affinities of serotonin (5-HT)-receptor antagonists and agonists at human recombinant α1-adrenoceptor subtypes (α1a-, α1b- and α1d-subtypes) were examined and compared with the functional affinities obtained in rat caudal artery (α1A-subtype), dog carotid artery (α1B-subtype) and rat thoracic aorta (α1D-subtype). … Most of the 5-HT-receptor antagonists and agonists tested showed relatively high affinity to three α1-adrenoceptor subtypes. …
NAID 10007122196

YAMAMOTO Yoshihisa,KOIKE Katsuo
日本平滑筋学会機関誌 35(5,6), 181-192, 1999-10
… In first, we tried to estimate the pA_2 values of some key α_1-adrenoceptor antagonists(prazosin, 5-methyl-urapidil, WB4101, BMY7378 and tamsulosin)against responses to norepinephrine in the thoracic aorta of guinea pigs. … The concentration-response curves of norepinephrine were rightward shifted by the presence of prazosin, 5-methylurapidil, WB4101, BMY7378 and tamsulosin. …
NAID 110002929795