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English Journal

Anti-diabetic drug metformin dilates retinal blood vessels through activation of AMP-activated protein kinase in rats.

Mori A1, Ishikawa E1, Amano T1, Sakamoto K1, Nakahara T2.
European journal of pharmacology.Eur J Pharmacol.2017 Jan 10. pii: S0014-2999(17)30003-1. doi: 10.1016/j.ejphar.2017.01.003. [Epub ahead of print]
The aim of this study was to examine whether metformin, a biguanide anti-hyperglycemic drug, dilates retinal blood vessels in rats. Ocular fundus images were captured with an original high-resolution digital fundus camera in vivo and diameters of retinal blood vessels were measured. Both systemic bl
PMID 28087254

5-Aminoimidazole-4-carboxamide ribonucleoside-mediated adenosine monophosphate-activated protein kinase activation induces protective innate responses in bacterial endophthalmitis.

Kumar A1, Giri S2, Kumar A1,3,4.
Cellular microbiology.Cell Microbiol.2016 Dec;18(12):1815-1830. doi: 10.1111/cmi.12625. Epub 2016 Jul 26.
The retina is considered to be the most metabolically active tissue in the body. However, the link between energy metabolism and retinal inflammation, as incited by microbial infection such as endophthalmitis, remains unexplored. In this study, using a mouse model of Staphylococcus aureus (SA) endop
PMID 27264993

Blunted response of hippocampal AMPK associated with reduced neurogenesis in older versus younger mice.

Jang S1, Kim H2, Jeong J3, Lee SK4, Kim EW5, Park M6, Kim CH7, Lee JE8, Namkoong K9, Kim E10.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2016 Nov 3;71:57-65. doi: 10.1016/j.pnpbp.2016.06.011. Epub 2016 Jun 22.
The rate of hippocampal neurogenesis declines with aging. This is partly explained by decreased neural responsiveness to various cues stimulating metabolism. AMP-activated protein kinase (AMPK), a pivotal enzyme regulating energy homeostasis in response to metabolic demands, showed the diminished se
PMID 27343360

AMPK Activation Stimulates Myofibrillar Protein Degradation and Expression of Atrophy-Related Ubiquitin Ligases by Increasing FOXO Transcription Factors in C2C12 Myotubes

NAKASHIMA Kazuki,YAKABE Yoko
Bioscience, biotechnology, and biochemistry 71(7), 1650-1656, 2007-07-23
… The present study was designed to examine the effect of 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside (AICAR)-induced AMPK signaling on effector mechanisms of myofibrillar protein degradation and the expression of atrophy-related genes (atrogin-1/MAFbx, MuRF1, proteasome C2 subunit, calpains, cathepsin B, and caspase-3) in C2C12 myotubes. …
NAID 10027516465

脂肪細胞におけるインスリン反応性糖輸送担体(GLUT4)の細胞膜への移送(translocation)と糖輸送活性に対するAMP活性化プロテインキナーゼ(AMPK)活性化の効果

山口真哉
杏林医学会雑誌 34(3), 139-152, 2003-09-30
… 3T3L1脂肪細胞におけるインスリン反応性糖輸送担体(GLUT4)の移送を可視化するために,そのN端にenhancement green fluorescent protein (eGFP)を融合させ,GLUT4-eGFP融合体(GLUT4-eGFP)を作製した。 … そして,種々の刺激下で,GLUT4-eGFP移送の経時的変化を共焦点レーザー顕微鏡下でリアルタイムに観察した。 …
NAID 110002672126

5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes