Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/29 11:55:14」(JST)

English Journal

Lactobacillus salivarius REN inhibit rat oral cancer induced by 4-nitroquioline 1-oxide.

Zhang M, Wang F, Jiang L, Liu RH, Zhang L, Lei X, Li J, Jiang J, Guo H, Fang B, Zhao L, Ren F.Source1College of Food Science and Nutritional Engineering, China Agricultural University.
Cancer prevention research (Philadelphia, Pa.).Cancer Prev Res (Phila).2013 May 8. [Epub ahead of print]
Despite of significant advances in cancer treatment, cancer related mobility and mortality are still rising. Alternative strategies such as cancer prevention thus become essential. Probiotics represent an emerging option for cancer prevention, but studies are limited to colon cancers. The efficiency
PMID 23658366

Enhancing the sensitivity of the comet assay as a genotoxicity test, by combining it with bacterial repair enzyme FPG.

Azqueta A, Arbillaga L, López de Cerain A, Collins A.SourceDepartment of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain and.
Mutagenesis.Mutagenesis.2013 May;28(3):271-7. doi: 10.1093/mutage/get002. Epub 2013 Feb 28.
The alkaline comet assay, when employed as a genotoxicity test, has relatively low sensitivity because it fails to detect-at non-cytotoxic concentrations-known genotoxins that do not induce breaks or alkali-labile sites. We demonstrate that this limitation is overcome by incorporating in the assay t
PMID 23448901

Geraniol modulates tongue and hepatic phase I and phase II conjugation activities and may contribute directly to the chemopreventive activity against experimental oral carcinogenesis.

Madankumar A, Jayakumar S, Gokuladhas K, Rajan B, Raghunandhakumar S, Asokkumar S, Devaki T.SourceDepartment of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamilnadu, India.
European journal of pharmacology.Eur J Pharmacol.2013 Apr 5;705(1-3):148-55. doi: 10.1016/j.ejphar.2013.02.048. Epub 2013 Mar 13.
Xenobiotic metabolizing enzymes are chief determinants in both the susceptibility to mutagenic effect of chemical carcinogens and in the response of tumors to chemotherapy. The present study was aimed to analyze the effect of geraniol administration on the activity of phase I and phase II carcinogen
PMID 23499697

Introduction of a Normal Human Chromosome 8 Corrects Abnormal Phenotypes of Werner Syndrome Cells Immortalized by Expressing an hTERT Gene

Ariyoshi Kentaro,Suzuki Keiji,Goto Makoto [他],Oshimura Mitsuo,Ishizaki Kanji,Watanabe Masami,Kodama Seiji
Journal of radiation research 50(3), 253-259, 2009-05-16
… Here, we demonstrate that the abnormal WS phenotypes including cellular sensitivities to 4-nitroquinoline-1-oxide (4NQO) and hydroxy urea (HU), and chromosomal radiosensitivity at G2 phase are corrected by expression of the WRN gene mediated by introducing a chromosome 8. …
NAID 10025911840

Suppressive effect of poly-gamma-glutamate on SOS response of Salmonella typhimurium induced by chemical mutagens

Sato Machiko,Kanie Kyoko,Soda Kenji [他],Yokoigawa Kumio
Journal of bioscience and bioengineering 105(6), 690-693, 2008-06-25
… and 4-nitroquinoline 1-oxide, 4NQO] and indirect [3-amino-1-methyl-5H-pyrido-(4,3-b) indole, Trp-P-2; …
NAID 110006792551

リンク元	「4-nitroquinoline-1-oxide」「4-ニトロキノリン-1-オキシド」

4-Nitroquinoline 1-oxide
	IUPAC name 4-nitroquinoline 1-oxide
Identifiers
CAS number	56-57-5
PubChem	5955
ChemSpider	5740
KEGG	C03474
ChEBI	CHEBI:16907
ChEMBL	CHEMBL127655
Jmol-3D images	Image 1
	SMILES [O-][N+](=O)c2c1c(cccc1)[n+]([O-])cc2 ;
	InChI InChI=1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H ; Key: YHQDZJICGQWFHK-UHFFFAOYSA-N InChI=1/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H; Key: YHQDZJICGQWFHK-UHFFFAOYAP ;
Properties
Molecular formula	C9H6N2O3
Molar mass	190.16 g mol−1
Hazards
Main hazards	causes DNA adducts. lactobacillus is being investigated for antigenotoxocity it causes.
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references