Induction of Expression of p75 Neurotrophin Receptor Intracellular Domain Does Not Induce Expression or Enhance Activity of Mitochondrial Complex II.
Yang YP1, Lotta L1, Beutner G1, Li X1, Schor NF1.
Oxidative medicine and cellular longevity.Oxid Med Cell Longev.2016;2016:8752821. doi: 10.1155/2016/8752821. Epub 2015 Nov 10.
Fenretinide is a chemotherapeutic agent in clinical trials for the treatment of neuroblastoma, among the most common and most deadly cancers of childhood. Fenretinide induces apoptosis in neuroblastoma cells through accumulation of mitochondrial reactive oxygen species released from Complex II. The
Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue.
Biochemical pharmacology.Biochem Pharmacol.2015 Nov 22. pii: S0006-2952(15)00745-5. doi: 10.1016/j.bcp.2015.11.017. [Epub ahead of print]
Fenretinide (FEN) is a synthetic retinoid that inhibits obesity and insulin resistance in high-fat diet (HFD)-fed mice and completely prevents 3T3-L1 pre-adipocyte differentiation. The aim of this study was to determine the mechanism(s) of FEN action in 3T3-L1 adipocytes and in mice. We used the 3T3
Bortezomib and fenretinide induce synergistic cytotoxicity in mantle cell lymphoma through apoptosis, cell-cycle dysregulation, and IκBα kinase downregulation.
Mantle cell lymphoma (MCL) remains incurable for most patients, and proteasome inhibitors like bortezomib induce responses in a minority of patients with relapsed disease. Fenretinide is a retinoid that has shown preclinical activity in B-cell lymphomas. We hypothesized that these agents could yield
An analog of all trans retinoic acid that shows antiproliferative activity on cultured human breast cancer cells. Highly selective activator of retinoid receptors. ... Effect of 4-hydroxyphenylretinamide and retinoic acid on proliferation and ...
Buy 4-Hydroxyphenylretinamide (CAS 65646-68-6), an agonist displaying activity at retinoid receptors, from Santa Cruz. MF: C26H33NO2, MW: 391.5 ... 4-Hydroxyphenylretinamide (Fenretinide) is a synthetic retinoid analog of all ...