4-ジメチルアミノフェノール
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/24 12:54:55」(JST)
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Not to be confused with 4-Dimethylaminopyridine.
| 4-Dimethylaminophenol |
|
| Identifiers |
| CAS number |
619-60-3 N |
| PubChem |
22174 |
| ChemSpider |
20816 Y |
| UNII |
X387L5559O Y |
| ATC code |
V03AB27 |
| Jmol-3D images |
Image 1 |
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InChI=1S/C8H11NO/c1-9(2)7-3-5-8(10)6-4-7/h3-6,10H,1-2H3 Y
Key: JVVRCYWZTJLJSG-UHFFFAOYSA-N Y
InChI=1/C8H11NO/c1-9(2)7-3-5-8(10)6-4-7/h3-6,10H,1-2H3
Key: JVVRCYWZTJLJSG-UHFFFAOYAU
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| Properties |
| Molecular formula |
C8H11NO |
| Molar mass |
137.179 g/mol |
| Boiling point |
165 °C (0.040 bar) |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
| N (verify) (what is: Y/N?) |
| Infobox references |
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4-Dimethylaminophenol (abbreviated in medical practice as DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.
Uses
4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.[1] It has also been shown to be effective in treating hydrogen sulfide toxicity.[2]
It works by generating methemoglobin. [3]
This is suitable as an emergency treatment only; treatment must be followed up with sodium thiosulfate or cobalamin.
In an animal model, it has shown effectiveness when given intramuscularly.[4]
See also
References
- ^ Kampe S, Iffland R, Korenkov M, Diefenbach C (December 2000). "Survival from a lethal blood concentration of cyanide with associated alcohol intoxication". Anaesthesia 55 (12): 1189–91. doi:10.1046/j.1365-2044.2000.01628.x. PMID 11121929.
- ^ Lindenmann J, Matzi V, Neuboeck N, Ratzenhofer-Komenda B, Maier A, Smolle-Juettner FM (December 2010). "Severe hydrogen sulphide poisoning treated with 4-dimethylaminophenol and hyperbaric oxygen". Diving and Hyperbaric Medicine : the Journal of the South Pacific Underwater Medicine Society 40 (4): 213–7. PMID 23111938. Retrieved 2013-06-07.
- ^ Vick JA, Von Bredow JD (1996). "Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival". J Appl Toxicol 16 (6): 509–16. doi:10.1002/(SICI)1099-1263(199611)16:6<509::AID-JAT382>3.0.CO;2-V. PMID 8956097.
- ^ Vick JA, Froehlich H (July 1991). "Treatment of cyanide poisoning". Mil Med 156 (7): 330–9. PMID 1922842.
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Antidotes (V03AB)
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Nervous
system |
Nerve agent /
Organophosphate
poisoning |
- Atropine#
- Biperiden
- Diazepam#
- Oximes
- see also: Cholinesterase
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Barbiturate
overdose
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Benzodiazepine
overdose
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GHB overdose
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Opioid overdose
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- Diprenorphine
- Doxapram
- Nalmefene
- Nalorphine
- Naloxone#
- Naltrexone
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Reversal of
neuromuscular blockade
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Circulatory
system |
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Beta blocker
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Digoxin toxicity
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Heparin
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| Other |
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Arsenic poisoning
|
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Cyanide poisoning
|
- 4-Dimethylaminophenol
- Hydroxocobalamin
- nitrite
- Amyl nitrite
- Sodium nitrite#
- Sodium thiosulfate#
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Hydrofluoric acid
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Methanol /
Ethylene glycol
poisoning |
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Paracetamol toxicity
(Acetaminophen)
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- Acetylcysteine#
- Glutathione
- Methionine#
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- Dimercaprol#
- Edetates
- Prussian blue#
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Other
|
- iodine-131
- Methylthioninium chloride#
- oxidizing agent
- Prednisolone/promethazine
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| Emetic |
- Copper sulfate
- Ipecacuanha
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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UpToDate Contents
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English Journal
- [Charcoal, cocaine and rattlesnakes: evidence-based treatment of poisoning].
- Schaper A.
- Der Anaesthesist.Anaesthesist.2013 Oct;62(10):824-31. doi: 10.1007/s00101-013-2229-z.
- BACKGROUND: Since ancient times poisoning has been treated medicinally. Clinical toxicology, in the narrow sense of the term, developed from the foundation of specialized medical treatment units for poisoning and the formation of the first poison information centers in the second half of the twentie
- PMID 24036518
- Common causes of poisoning: etiology, diagnosis and treatment.
- Müller D1, Desel H.
- Deutsches Ärzteblatt international.Dtsch Arztebl Int.2013 Oct;110(41):690-9; quiz 700. doi: 10.3238/arztebl.2013.0690. Epub 2013 Oct 11.
- BACKGROUND: In 2011, German hospitals treated approximately 205 000 patients suffering from acute poisoning. Change is seen over time both in the types of poisoning that occur and in the indications for specific treatment.METHODS: This article is based on a selective review of the literature, with s
- PMID 24194796
- Review article: management of cyanide poisoning.
- Reade MC1, Davies SR, Morley PT, Dennett J, Jacobs IC; Australian Resuscitation Council.
- Emergency medicine Australasia : EMA.Emerg Med Australas.2012 Jun;24(3):225-38. doi: 10.1111/j.1742-6723.2012.01538.x. Epub 2012 Feb 21.
- Cyanide poisoning is uncommon, but generates interest because of the presumed utility of an antidote immediately available in those areas with a high risk of cyanide exposure. As part of its regular review of guidelines, the Australian Resuscitation Council conducted a systematic review of the human
- PMID 22672162
Japanese Journal
- Determination of 4-dimethylaminophenol concentrations in dog blood using LC-ESI/MS/MS combined with precolumn derivatization
- ZHUANG Xiao Mei,YUAN Mei,ZHANG Zhi Wei,WANG Xiao Ying,ZHANG Zhen Qing,RUAN Jin Xiu
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 876(1), 76-82, 2008-12-01
- NAID 10028010433
Related Links
- Structure, properties, spectra, suppliers and links for: 4-Dimethylaminophenol. ... Predicted data is generated using the US Environmental Protection Agency’s EPISuite , for more information see their website. Log Octanol-Water ...
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