3-hydroxybutyrate dehydrogenase

3-ヒドロキシ酪酸脱水素酵素、3-ヒドロキシ酪酸デヒドロゲナーゼ

関

hydroxybutyrate dehydrogenase

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/01 20:36:55」(JST)

wiki en

[Wiki en表示]

3-Hydroxybutyrate dehydrogenase
Identifiers
EC number	1.1.1.30
CAS number	9028-38-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI Protein search

In enzymology, a 3-hydroxybutyrate dehydrogenase (EC 1.1.1.30) is an enzyme that catalyzes the chemical reaction

(R)-3-hydroxybutanoate + NAD⁺ acetoacetate + NADH + H⁺

Thus, the two substrates of this enzyme are (R)-3-hydroxybutanoate and NAD⁺, whereas its 3 products are acetoacetate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, to be specific, those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-3-hydroxybutanoate:NAD⁺ oxidoreductase. Other names in common use include NAD⁺-beta-hydroxybutyrate dehydrogenase, hydroxybutyrate oxidoreductase, beta-hydroxybutyrate dehydrogenase, D-beta-hydroxybutyrate dehydrogenase, D-3-hydroxybutyrate dehydrogenase, D-(-)-3-hydroxybutyrate dehydrogenase, beta-hydroxybutyric acid dehydrogenase, 3-D-hydroxybutyrate dehydrogenase, and beta-hydroxybutyric dehydrogenase. This enzyme participates in synthesis and degradation of ketone bodies and butanoate metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1WMB and 1X1T.

See also

• BDH1

References

• Bergmeyer HU, Gawehn K, Klotzsch H, Krebs HA, Williamson DH (1967). "Purification and properties of crystalline 3-hydroxybutyrate dehydrogenase from Rhodopseudomonas spheroides". Biochem. J. 102 (2): 423–31. PMC 1270263. PMID 4291491. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1270263/.
• Delafield FP, Cooksey KE, Doudoroff M (1965). "beta-Hydroxybutyric dehydrogenase and dimer hydrolase of Pseudomonas lemoignei". J. Biol. Chem. 240 (10): 4023–8. PMID 4954074.
• Lehninger AL, Sudduth HC and Wise JB (1960). "D-beta-Hydroxybutyric dehydrogenase of mitochondria". J. Biol. Chem. 235: 2450–2455. PMID 14415394.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. ガンマヒドロキシブチレート（GHB）中毒 gamma hydroxybutyrate ghb intoxication
• 2. グルコース-6-リン酸脱水素酵素欠損症の診断および治療 diagnosis and treatment of glucose 6 phosphate dehydrogenase deficiency
• 3. 幼児の持続性高インスリン血症性低血糖症の病因、臨床的特徴、および診断 pathogenesis clinical features and diagnosis of persistent hyperinsulinemic hypoglycemia of infancy
• 4. ガンマヒドロキシブチレート（GHB）への依存および離脱 gamma hydroxybutyrate ghb dependence and withdrawal
• 5. 乳酸脱水素酵素欠損症 lactate dehydrogenase deficiency

English Journal

• Increased NADPH availability in Escherichia coli: improvement of the product per glucose ratio in reductive whole-cell biotransformation.

• Siedler S, Bringer S, Bott M.SourceInstitut für Bio- und Geowissenschaften, IBG-1: Biotechnologie, Forschungszentrum Jülich, 52425, Jülich, Germany.
• Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2011 Dec;92(5):929-37. Epub 2011 Jun 14.
• A basic requirement for the efficiency of reductive whole-cell biotransformations is the reducing capacity of the host. Here, the pentose phosphate pathway (PPP) was applied for NADPH regeneration with glucose as the electron-donating co-substrate using Escherichia coli as host. Reduction of the pro
• PMID 21670981

• The effects of different environmental conditions on thermoregulation and clinical and hematological parameters in long-distance road-transported calves.

• Bernardini D, Gerardi G, Peli A, Nanni Costa L, Amadori M, Segato S.SourceDepartment of Veterinary Clinical Sciences, University of Padova, 35020 Legnaro (PD), Italy.
• Journal of animal science.J Anim Sci.2011 Nov 18. [Epub ahead of print]
• The aim of this study was to investigate the effects of long-distance road transport (19 h, from Poland to Italy) during 2 seasons (summer vs. winter) on clinical and hematological parameters in calves. The environmental temperature range that could compromise the calves' thermoregulation system (th
• PMID 22100587

Japanese Journal

• Aerobic utilization of crude glycerol by recombinant Escherichia coli for simultaneous production of poly 3-hydroxybutyrate and bioethanol

• Shah Pramod,Chiu Feng-Shen,Lan John Chi-Wei
• Journal of bioscience and bioengineering 117(3), 343-350, 2014-03
• NAID 40020024059

• Aerobic utilization of crude glycerol by recombinant Escherichia coli for simultaneous production of poly 3-hydroxybutyrate and bioethanol(BIOCHEMICAL ENGINEERING)

• Shah Pramod,Chiu Feng-Shen,Lan John Chi-Wei
• Journal of bioscience and bioengineering 117(3), 343-350, 2014-03
• … coli strains were constructed for the simultaneous production of poly 3-hydroxybutyrate (P3HB) and bioethanol from crude glycerol. … The incorporation of aldehyde reductase (Alrd) and aldehyde dehydrogenase (AldH) in recombinant strain showed 2-fold increment in crude glycerol utilization under aerobic condition. … Subsequently, acetate was utilized as substrate in the second pathway, which directly converted acetyl-CoA to P3HB. …
• NAID 110009815388

• Modification of β-oxidation pathway in Ralstonia eutropha for production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) from soybean oil(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)

• Insomphun Chayatip,Mifune Jun,Orita Izumi [他],Numata Keiji,Nakamura Satoshi,Fukui Toshiaki
• Journal of bioscience and bioengineering 117(2), 184-190, 2014-02
• … This study focused on bifunctional (S)-specific 2-enoyl-CoA hydratase/(S)-3-hydroxyacyl-CoA dehydrogenase encoded byfadB to obtain information regarding β-oxidation in this bacterium and to achieve compositional regulation of poly((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) [P(3HB-co-3HHx)] synthesized from soybean oil. …
• NAID 110009804070

Related Links

• 3‒HYDROXYBUTYRATE DEHYDROGENASE [3‒HBDHⅡ]

110 （Diagnostic Reagent Grade） ASAHI KASEI ENZYMES T－68 3‒HYDROXYBUTYRATE DEHYDROGENASE [3‒HBDHⅡ] from Alcaligenes faecalis （D‒3‒Hydroxybutyrate: NAD + oxidoreductase, EC 1.1.1.30）

• 3 hydroxybutyrate dehydrogenase - Labome.Org | Research ...

Species, Scientific Experts, Genomes and Genes, Research Grants, Publications, Research Topics about 3 hydroxybutyrate dehydrogenase ... Luciana M Melo Laboratório de Moléculas Biologicamente Ativas BioMol Lab ...

---

★リンクテーブル★

リンク元	「hydroxybutyrate dehydrogenase」「3-ヒドロキシ酪酸脱水素酵素」
関連記事	「hydroxybutyrate dehydrogenase」「dehydrogenase」「dehydrogenases」

「hydroxybutyrate dehydrogenase」

　　[★]

ヒドロキシ酪酸脱水素酵素、ヒドロキシ酪酸デヒドロゲナーゼ

関

3-hydroxybutyrate dehydrogenase

「3-ヒドロキシ酪酸脱水素酵素」

　　[★]

英

3-hydroxybutyrate dehydrogenase, 3-HBD

同

3-ヒドロキシ酪酸デヒドロゲナーゼ

「hydroxybutyrate dehydrogenase」

　　[★]

ヒドロキシ酪酸脱水素酵素、ヒドロキシ酪酸デヒドロゲナーゼ

関

3-hydroxybutyrate dehydrogenase

「dehydrogenase」

　　[★] 脱水素酵素 デヒドロゲナーゼ

「dehydrogenases」

　　[★] 脱水素酵素 デヒドロゲナーゼ