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1. 有毛細胞白血病の治療treatment of hairy cell leukemia [show details]
…assessed four to six months after the conclusion of primary therapy. The purine analogs pentostatin (2'-deoxycoformycin, 2'-DCF) and cladribine (2-chlorodeoxyadenosine, 2-CdA) are naturally targeted to lymphocytes …
2. T細胞性前リンパ性白血病の治療treatment of t cell prolymphocytic leukemia [show details]
…combination of alemtuzumab plus pentostatin is discussed in the following section. Pentostatin is the purine analog that has demonstrated the greatest activity in T-PLL. Pentostatin has been evaluated in retrospective …
3. 腎障害患者に生じる抗がん剤の腎毒性と用量調整：既存の細胞障害性抗がん剤chemotherapy nephrotoxicity and dose modification in patients with kidney impairment conventional cytotoxic agents [show details]
…The elimination of many antimetabolites, including capecitabine, methotrexate, fludarabine, and pentostatin, is at least partially dependent upon kidney function. Of the clinically useful antimetabolites …
4. アントラサイクリン、HER2-標的製剤、フルオロピリミジン以外の癌化学療法剤の心毒性cardiotoxicity of cancer chemotherapy agents other than anthracyclines her2 targeted agents and fluoropyrimidines [show details]
…either agent alone in high doses has only rarely been associated with cardiac toxicity. Pentostatin (2'-deoxycoformycin) and cladribine (2-chlorodeoxyadenosine) are additional purine antagonists used in hematologic…
5. 慢性リンパ性白血病患者における感染症リスクrisk of infections in patients with chronic lymphocytic leukemia [show details]
…transplant . As with fludarabine, treatment with cladribine (2-chlorodeoxyadenosine) or pentostatin (deoxycoformycin) also results in quantitative T cell subset abnormalities that persist for up to one to …

English Journal

Adenosine deaminase inhibition suppresses progression of 4T1 murine breast cancer by adenosine receptor-dependent mechanisms.

Kutryb-Zajac B, Koszalka P, Mierzejewska P, Bulinska A, Zabielska MA, Brodzik K, Skrzypkowska A, Zelazek L, Pelikant-Malecka I, Slominska EM, Smolenski RT.
Journal of cellular and molecular medicine. 2018 Dec;22(12)5939-5954.
The activity of a cell-surface ecto-adenosine deaminase (eADA) is markedly increased in the endothelial activation and vascular inflammation leading to decreased adenosine concentration and alterations in adenosine signalling. Depending on the specific pathway activated, extracellular purines mediat
PMID 30291675

Durable Resolution of Severe Psoriasis in a Patient Treated with Pentostatin for Hairy Cell Leukemia: A Case Report.

Alsuliman T, Lassoued K, Belghoul M, Debbache K, Choufi B.
Dermatology and therapy. 2018 Mar;8(1)165-169.
Pentostatin (2'-deoxycoformycin) and cladribine (2-chlorodeoxyadenosine) are adenosine analogues widely used to treat lymphoid malignancies, mainly hairy cell leukemia (HCL). Oral or parenteral adenosine analogues have been also used as immunomodulatory agents in multiple sclerosis and in acute graf
PMID 29196889

Biosynthesis of 2'-Chloropentostatin and 2'-Amino-2'-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in sp. Strain ATCC 39365.

Gao Y, Xu G, Wu P, Liu J, Cai YS, Deng Z, Chen W.
Applied and environmental microbiology. 2017 05;83(10).
2'-Chloropentostatin (2'-Cl PTN, 2'-chloro-2'-deoxycoformycin) and 2'-amino-2'-deoxyadenosine (2'-amino dA) are two adenosine-derived nucleoside antibiotics coproduced by sp. strain ATCC 39365. 2'-Cl PTN is a potent adenosine deaminase (ADA) inhibitor featuring an intriguing 1,3-diazepine ring, as
PMID 28258148

Related Pictures

WHAT IS TRANSFER FACTOR? - ppt download Newer Purine Analogues for the Treatment of Hairy-Cell Leukemia | NEJM Пентостатин (син.: 2-DCF, Дезоксикоформицин, 2 Pentostatin; 2'-Deoxycoformycin Remissions in Hairy-Cell Leukemia with Pentostatin (2′-Deoxycoformycin) | NEJM