In order to estimate the free energy barrier to rotation around the C1-C11 single bond in lamellarins, new lamellarin analogues (1a), (1b), (2a), and (2b) possessing diastereotopic protons or carbons …
Diastereoselective Synthesis of 3-Fluoro-2-substituted Piperidines and Pyrrolidines
Gichuhi Paul N.,Kuriyama Masami,Onomura Osamu
HETEROCYCLES 88(1), 331-346, 2014
A facile procedure for synthesis of trans-3-fluoro-2-substituted piperidines by utilizing electrophilic fluorination of cyclic enamines and Lewis acid mediated nucleophilic substitution has been devel …