histiocytes

WordNet

1. a macrophage that is found in connective tissue

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/03/18 16:59:19」(JST)

wiki en

[Wiki en表示]

Histiocyte
Details
Identifiers
Latin	macrophagocytus immobilis
Code	TH H2.00.03.0.01009
Anatomical terminology [edit on Wikidata]

A histiocyte is an animal cell that is part of the mononuclear phagocyte system (also known as the reticuloendothelial system or lymphoreticular system). The mononuclear phagocytic system is part of the organism's immune system. The histiocyte is a tissue macrophage or a dendritic cell (histio, diminutive of histo, meaning tissue, and cyte, meaning cell).

Terminology

Histiocytes are derived from the bone marrow by multiplication from a stem cell. The derived cells migrate from the bone marrow to the blood as monocytes. They circulate through the body and enter various organs, where they undergo differentiation into histiocytes, which are part of the mononuclear phagocytic system (MPS).

However, the term histiocyte has been used for multiple purposes in the past, and some cells called "histocytes" do not appear to derive from monocytic-macrophage lines. (The term Histiocyte can also simply refer to a cell from monocyte origin outside the blood system, such as in a tissue (as in rheumatoid arthritis as palisading histiocytes surrounding fibrinoid necrosis of rheumatoid nodules).

Some sources consider Langerhans cell derivatives to be histiocytes. The Langerhans cell histiocytosis embeds this interpretation into its name.

Morphology and diversity

Histiocytes have common histological and immunophenotypical characteristics (demonstrated by immunostains). Their cytoplasm is eosinophilic and contains variable amounts of lysosomes. They bear membrane receptors for opsonins, such as IgG and the fragment C3b of complement. They express LCAs (leucocyte common antigens) CD45, CD14, CD33, and CD4 (also expressed by T Helper Cells).

Macrophages and dendritic cells

These histiocytes are part of the immune system by way of two distinct functions: phagocytosis and antigen presentation. Phagocytosis is the main process of macrophages and antigen presentation the main property of dendritic cells (so called because of their star-like cytoplasmic processes).

Macrophages and dendritic cells are derived from common bone marrow precursor cells that have undergone different differentiation (as histiocytes) under the influence of various environmental (tissue location) and growth factors such as GM-CSF, TNF and IL-4. The various categories of histocytes are distinguishable by their morphology, phenotype, and size.

• Macrophages are highly variable in size and morphology, their cytoplasm contains numerous acid phosphatase laden lysosomes - in relation to their specialised phagocytic function. They express CD68.
• Dendritic cells have an indented (bean-shaped) nucleus and cytoplasm with thin processes (dendritic). Their main activity is antigen presentation; they express Factor XIIIa, CD1c, and Class II Human leukocyte antigens.

Langerhans cells

A subset of cells differentiates into Langerhans cells; this maturation occurs in the squamous epithelium, lymph nodes, spleen, and bronchiolar epithelium. Langerhans cells are antigen-presenting cells but have undergone further differentiation. Skin Langerhans cells express CD1a, as do cortical thymocytes (cells of the cortex of the thymus gland). They also express S-100, and their cytoplasm contains tennis-racket like ultra-structural inclusions called Birbeck granules.

Disorders

Histiocytoses describe neoplasias wherein the proliferative cell is the histiocyte.

The most common histiocyte disorders are Langerhans' cell histiocytosis and haemophagocytic lymphohistiocytosis.

See also

• Histiocytosis

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 慢性骨髄性白血病の臨床症状および診断 clinical manifestations and diagnosis of chronic myeloid leukemia
• 2. 骨髄穿刺塗抹標本の評価 evaluation of bone marrow aspirate smears
• 3. ニーマン・ピック病の概要 overview of niemann pick disease

English Journal

• Bone Marrow Suppression and Hemophagocytic Histiocytes Are Common Findings in Korean Severe Fever with Thrombocytopenia Syndrome Patients.

• Shin SY1, Cho OH2, Bae IG2.
• Yonsei medical journal.Yonsei Med J.2016 Sep;57(5):1286-9. doi: 10.3349/ymj.2016.57.5.1286.
• The causes of cytopenia in patients with severe fever with thrombocytopenia syndrome (SFTS) are not fully understood until now. We reviewed the bone marrow (BM) findings of patients with SFTS to unravel the cause of the cytopenia. Three Korean SFTS were enrolled in this study. Thrombocytopenia, neut
• PMID 27401664

• Erythrophagocytosis by peripheral monocytes and histiocytes in diffuse large B cell lymphoma.

• Pedrote B1, Morales-Camacho RM1, Vargas MT1, Castillo E2, Bernal R1, Prats-Martín C3.
• Annals of hematology.Ann Hematol.2016 Aug;95(8):1353-5. doi: 10.1007/s00277-016-2685-z. Epub 2016 May 2.
• PMID 27138921

• Papillary Renal Cell Carcinoma Arising in a Lymph Node Metastasis of a Testicular Teratoma: A Very Rare Occurrence.

• Ozturk Sari S1, Ozluk Y2, Taskin OC2, Polat B2, Ozturk I2, Ekenel M2, Kilicaslan I2, Bilgic B2.
• International journal of surgical pathology.Int J Surg Pathol.2016 Aug;24(5):468-72. doi: 10.1177/1066896916635817. Epub 2016 Mar 1.
• We present a case of a teratoma with somatic type malignancy (TSM) in the form of papillary renal cell carcinoma (pRCC) within supraclavicular and retroperitoneal lymph node metastases of a testicular pure teratoma. Resection of both masses revealed a teratoma without any other germ cell tumor compo
• PMID 26936856

Japanese Journal

• 狭帯域光観察(NBI)内視鏡および超音波内視鏡(EUS)にて観察された，黄色腫混在過形成ポリープの一例

• Fukuda Shin-ichiro,Akahoshi Kazuya,Fushimi Fumiyoshi,Oya Masafumi
• Fukuoka Acta Medica 106(4), 77-82, 2015-04-25
• … Histological examination of the specimen of the fornix polyp revealed lengthened, branched and dilatated gastric foveolae and a tight sheet of foamy histiocytes in the stroma. …
• NAID 120005615448

• インスリン注射による皮下腫瘤の病理組織，画像所見およびインスリン吸収についての検討

• 楠 和久,吉嵜 友之,竹田 朋子 [他],本田 宗宏
• 糖尿病 58(6), 388-397, 2015
• インスリン治療中の糖尿病患者で腹部のインスリン注射部位に皮下腫瘤を認めた10例において，病理組織や画像検査，インスリン吸収について詳細な検討を行った．病理では4例に主としてアミロイド沈着を，6例に主として膠原線維増生を認めた．アミロイド沈着・膠原線維増生ともに異物型巨細胞や類上皮細胞肉芽腫を認め，組織球がインスリンを貪食している所見も認めた．画像検査ではアミロイド沈着は体表超音波では深部減衰を伴う …
• NAID 130005087451

Related Links

• Histiocytes - definition of Histiocytes by Medical dictionary

Definition of Histiocytes in the Medical Dictionary. Histiocytes explanation. Information about Histiocytes in Free online English dictionary. What is Histiocytes? Meaning of Histiocytes medical term. What does Histiocytes mean? ...

• Histiocytes definition of Histiocytes in the Free Online ...

Histiocytes (wandering cells at rest; polyblasts; clasmatocytes), cells of reticular connective tissue in vertebrate animals and humans. Histiocytes are sharply contoured, with basophilic cytoplasm, in which there are often vacuoles ...

Related Pictures