English Journal

Physicochemical characterization of glybuzole polymorphs and their pharmaceutical properties.

Otsuka M, Ofusa T, Matsuda Y.SourceDepartment of Pharmaceutical Technology, Kobe Pharmaceutical University, Japan.
Drug development and industrial pharmacy.Drug Dev Ind Pharm.1999 Feb;25(2):197-203.
Systematic polymorphic screening tests were performed using 11 kinds of solvents and 6 kinds of preparation methods, and the three specific modifications of glybuzole (forms I and II and amorphous form) were identified by X-ray diffractometry and differential thermal analysis (DTA). The physicochemi
PMID 10065353

[Metabolism of glybuzole(2-benzenesulfonamido-5-tert-butyl-1-thia-3,4-diazole) in rats after pretreatment of phenobarbital, SKF 525A and carbon tetrachloride (author's transl)].

Ishi A, Oishi T, Endo M, Mineura K.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.Yakugaku Zasshi.1978 Sep;98(9):1208-14.
PMID 731392

Japanese Journal

須藤孝子,鐘ヶ江孝,名児耶忠章,吉田昌記,石川典子,富永良子,寺岡敦,嶋村政男,塚本昭次郎,佐藤喜宣
日本アルコール・薬物医学会雑誌 = Japanese journal of alcohol studies & drug dependence 38(3), 242-243, 2003-06-28
NAID 10011053055

Dissolution Improvement of Water-Insoluble Glybuzole by Co-Grinding and Co-Melting with Surfactants and Their Physicochemical Properties

Glybuzole(2-Benzenesulfonamido-5-tert-butyl-1-thia-3,4-diazole)のフエノバルビタール, SKF 525Aおよび四塩化炭素前処理ラットにおける代謝

石井昭男 [他],大石孝義,遠藤守俊,峯浦和幸
藥學雜誌 98(9), 1208-1214, 1978-09-25
… Absorption, excretion, and metabolism of Glybuzole (2-benzenesulfonamido-5-tert-butyl-1-thia-3,4-diazole) were studied in normal rats, and rats pretreated with phenobarbital, SKF 525A, or carbon tetrachloride. … Plasma half-life of ^<14>C-Glybuzole after its oral administration was affected by the pretreatment ; … Urinary, fecal, and biliary excretion of Glybuzole was also affected by these pretreatments. …
NAID 110003652874