- 関
- fluvastatin
WordNet
- a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11
- least expensive statin drug (trade name Lescol); usually taken orally at bedtime (同)Lescol
PrepTutorEJDIC
- ソジウム,ナトリウム(金属元素;化学記号はNa)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/10/10 09:37:43」(JST)
[Wiki en表示]
Fluvastatin
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Systematic (IUPAC) name |
(3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid |
Clinical data |
Trade names |
Lescol |
AHFS/Drugs.com |
monograph |
MedlinePlus |
a694010 |
Pregnancy cat. |
? |
Legal status |
℞ Prescription only |
Routes |
Oral |
Pharmacokinetic data |
Protein binding |
98% |
Half-life |
2.5 hours |
Identifiers |
CAS number |
93957-54-1 Y |
ATC code |
C10AA04 |
PubChem |
CID 446155 |
DrugBank |
DB01095 |
ChemSpider |
393587 Y |
UNII |
4L066368AS Y |
KEGG |
D07983 Y |
ChEBI |
CHEBI:38565 Y |
ChEMBL |
CHEMBL1078 Y |
Chemical data |
Formula |
C24H26FNO4 |
Mol. mass |
411.466 g/mol |
SMILES
- O=C(O)C[C@H](O)C[C@H](O)/C=C/c2c(c1ccccc1n2C(C)C)c3ccc(F)cc3
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InChI
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InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1 Y
Key:FJLGEFLZQAZZCD-MCBHFWOFSA-N Y
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Y (what is this?) (verify)
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Fluvastatin (trade names Lescol, Canef, Vastin) is a member of the drug class of statins, used to treat hypercholesterolemia and to prevent cardiovascular disease.
It has also been shown to exhibit antiviral activity against Hepatitis C in a study with 31 patients. This effect has been described as modest, variable, and often short-lived by the authors.[1]
References[edit]
- ^ Bader T, Fazili J, Madhoun M, et al. (April 2008). "Fluvastatin Inhibits Hepatitis C Replication in Humans". Am. J. Gastroenterol. 103 (6): 1383–9. doi:10.1111/j.1572-0241.2008.01876.x. PMID 18410471.
Lipid modifying agents (C10)
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GI tract |
Cholesterol absorption inhibitors, NPC1L1
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Bile acid sequestrants/resins (LDL)
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- Cholestyramine
- Colestipol
- Colestilan
- Colextran
- Colesevelam
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Liver |
Statins (HMG-CoA reductase, LDL)
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- Simvastatin#
- Atorvastatin
- Fluvastatin
- Lovastatin
- Mevastatin
- Pitavastatin
- Pravastatin
- Rosuvastatin
- Cerivastatin‡
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Niacin and derivatives (HDL and LDL)
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- Niceritrol
- Niacin
- Nicofuranose
- Aluminium nicotinate
- Nicotinyl alcohol
- Acipimox
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MTTP inhibitors (VLDL)
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- Dirlotapide
- Lomitapide
- Mitratapide
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Blood vessels |
Fibrates (PPAR)
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- Clofibrate‡
- Bezafibrate
- Aluminium clofibrate
- Gemfibrozil
- Fenofibrate
- Simfibrate
- Ronifibrate
- Ciprofibrate
- Etofibrate
- Clofibride
- Clinofibrate
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CETP inhibitors (HDL)
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- Anacetrapib†
- Dalcetrapib§
- Evacetrapib§
- Torcetrapib†
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Combinations |
- Niacin/lovastatin
- Niacin/simvastatin
- Ezetimibe/simvastatin
- Ezetimibe/atorvastatin
- Niacin/laropiprant
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Other |
- Dextrothyroxine‡
- Probucol
- Tiadenol
- Benfluorex
- Meglutol
- Omega-3-triglycerides
- Magnesium pyridoxal 5-phosphate glutamate
- Policosanol
- Lapaquistat§
- Mipomersen
- Alipogene tiparvovec
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Statin use and the risk of Clostridium difficile in academic medical centres.
- Motzkus-Feagans CA, Pakyz A, Polk R, Gambassi G, Lapane KL.SourceDepartment of Epidemiology and Community Health, Virginia Commonwealth University, School of Medicine, 830 E. Main Street, RM 5010, P.O. Box 980212, Richmond, VA 23298-0212, USA; motzkusca@vcu.edu.
- Gut.Gut.2012 Nov;61(11):1538-42. Epub 2012 Mar 22.
- OBJECTIVES: To estimate the possible relationship between statin use and the risk of healthcare facility onset Clostridium difficile.METHODS: Patients over 18 years of age admitted to hospitals contributing data to the University HealthSystem Consortium between 2002 and 2009 were eligible. Patients
- PMID 22442166
- Statins modulate transcriptional activity of heme-oxygenase-1 promoter in NIH 3T3 Cells.
- Mrad MF, Mouawad CA, Al-Hariri M, Eid AA, Alam J, Habib A.SourceDepartment of Biochemistry and Molecular Genetics, American University of Beirut, POBox 11-236, Lebanon.
- Journal of cellular biochemistry.J Cell Biochem.2012 Nov;113(11):3466-75. doi: 10.1002/jcb.24223.
- Statins, inhibitors of HMG CoA reductase, have pleiotropic effects independent of their capacity to lower cholesterol. Heme-oxygenase-1(HO-1) plays an important role as an anti-oxidant and anti-inflammatory enzyme. In the present study, we used NIH 3T3 cells which express HO-1 to investigate the mol
- PMID 22689023
Japanese Journal
- 市販薬およびフルバスタチンナトリウムによる薬物性肝障害を発症した Gilbert 症候群の1例
- 綾田 穣,石川 哲也,奥村 明彦,堀田 直樹,広瀬 昭憲,増子 和郎,各務 伸一
- 肝臓 50(3), 139-144, 2009-03-25
- 症例は,56歳女性.心窩部痛と嘔吐に対し市販薬を内服するも改善せず,外来を受診.黄疸,肝胆道系酵素の上昇を認めたため入院となった.市販薬による薬物性肝障害を疑い,内服を中止.肝障害は軽快した.退院後,高脂血症に対しフルバスタチンナトリウムを投与したところ再び肝障害が出現した.内服中止により,肝障害は改善したが,以後も持続する間接ビリルビン優位の高ビリルビン血症を認めた.Gilbert症候群を疑い, …
- NAID 10024804922
- 和智 恵子,石井 耕司,池原 孝,篠原 正夫,川船 隆史,住野 泰清,野中 博子
- 東邦醫學會雜誌 = Journal of the Medical Society of Toho University 48(2), 153-158, 2001-03-01
- NAID 10012206486
Related Links
- fluvastatin sodium (floo´v stat´ n sōdē m), n brand name: Lescol; drug class: cholesterol-lowering agent; action: inhibits HMG-CoA reductase enzyme, which reduces cholesterol synthesis; uses: adjunct in primary ...
- Children treated with fluvastatin in adolescence should be reevaluated in adulthood and appropriate changes made to their cholesterol-lowering regimen to achieve adult treatment goals. 1.2 Secondary Prevention of Cardiovascular ...
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- 英
- fluvastatin、
- 化
- フルバスタチンナトリウム fluvastatin sodium
- 商
- ローコール