関: epinastine hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/04 02:18:37」(JST)

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Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States.^[1] It is highly selective for the H₁ receptor and does not cross the blood-brain-barrier.^[2]

References

^ Pradhan, S; Abhishek, K; Mah, F (2009). "Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects". Expert opinion on drug metabolism & toxicology 5 (9): 1135–40. doi:10.1517/17425250903117284. PMID 19630694.
^ Walther G, Daniel H, Bechtel WD, Brandt K (April 1990). "New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine". Arzneimittel-Forschung 40 (4): 440–6. PMID 1972625.

External links

Official U.S. website of Elestat

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UpToDate Contents

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1. アレルギー性結膜炎：マネージメント allergic conjunctivitis management
2. アレルギー性鼻炎の薬物療法 pharmacotherapy of allergic rhinitis
3. 巨大乳頭結膜炎 giant papillary conjunctivitis
4. 春季カタル vernal keratoconjunctivitis
5. 患者情報：結膜炎（ピンクアイ）（詳細） conjunctivitis pinkeye beyond the basics

English Journal

Perturbation of tyraminergic/octopaminergic function inhibits oviposition in the cattle tick Rhipicephalus (Boophilus) microplus.

Cossío-Bayúgar R, Miranda-Miranda E, Narváez Padilla V, Olvera-Valencia F, Reynaud E.SourceCentro Nacional de Investigación Disciplinaria en Parasitología Veterinaria, Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias INIFAP, Carr. Fed. Cuernavaca-Cuautla No. 8534, Jiutepec, Morelos, CP 62550, Mexico.
Journal of insect physiology.J Insect Physiol.2012 May;58(5):628-33. Epub 2012 Feb 17.
The cattle tick Rhipicephalus microplus, is one of the most damaging livestock ectoparasites. Tropical tick infestation limits the introduction of high-yield bovine varieties because they do not have immunity to the diseases transmitted by these ectoparasites. This tick is usually controlled with ch
PMID 22343017

Pharmacological characterization of adenosine receptors on isolated human bronchi.

Calzetta L, Spina D, Cazzola M, Page CP, Facciolo F, Rendina EA, Matera MG.SourceDepartment of Internal Medicine, University of Rome "Tor Vergata," Italy.
American journal of respiratory cell and molecular biology.Am J Respir Cell Mol Biol.2011 Dec;45(6):1222-31. Epub 2011 Jun 23.
Adenosine induces airways obstruction in subjects with asthma, but the receptor subtype responsible remains unknown. The objectives of this study were to determine the pharmacological profile of adenosine receptor subtypes mediating contraction and to investigate the mechanism in normal and passivel
PMID 21700958

Japanese Journal

スギ花粉アレルギー性結膜炎に及ぼすエピナスチン塩酸塩点眼液の影響

深川和己,三宅秀樹,萩原由美 [他]
アレルギー・免疫 21(1), 126-133, 2014-01
NAID 40019920618

A Case of IgG4-Related Dacryoadenitis that Regressed Without Systemic Steroid Administration

Ohshima Koh-ichi,Sato Yasuharu,Yoshino Tadashi
Journal of Clinical and Experimental Hematopathology 53(1), 53-56, 2013
… In addition to the observation of lacrimal gland lesions, the administration of epinastine hydrochloride at a dosage of 20 mg/day and 0.01% betamethasone eye drops twice a day to both eyes was commenced in order to treat both allergic rhinitis and allergic conjunctivitis. … The hypotheses of spontaneous remission and/or the effect of epinastine hydrochloride administration can be proposed regarding the mechanism by which the lacrimal gland lesion decreased in size. …
NAID 130003366787

スギ花粉症に対してステロイド鼻噴霧薬と抗ヒスタミン薬併用投与の意義はあるか?

市村恵一,菊池恒,今吉正一郎
耳鼻咽喉科臨床 105(11), 1107-116, 2012-11-01
… Group 1 received only intranasal mometasone furoate (MF), and group 2 received intranasal MF and oral epinastine hydrochloride. …
NAID 10031128277

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リンク元	「エピナスチン」
拡張検索	「epinastine hydrochloride」

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Epinastine
Systematic (IUPAC) name
	(RS)-3-amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine
Clinical data
Trade names	Alesion, Elestat, Purivist, Relestat
AHFS/Drugs.com	monograph
MedlinePlus	a604011
Pregnancy; category	C;
Routes of; administration	Eye drops
Pharmacokinetic data
Protein binding	64%
Biological half-life	12 hours
Identifiers
CAS Number	80012-43-7
ATC code	R06AX24 S01GX10
PubChem	CID: 3241
IUPHAR/BPS	7176
DrugBank	DB00751
ChemSpider	3128
UNII	Q13WX941EF
KEGG	D07900
ChEBI	CHEBI:51032
ChEMBL	CHEMBL1106
Chemical data
Formula	C16H15N3
Molecular mass	249.311 g/mol
	SMILES N\4=C(\N3c1c(cccc1)Cc2c(cccc2)C3C/4)N ;
	InChI InChI=1S/C16H15N3/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16/h1-8,15H,9-10H2,(H2,17,18) ; Key:WHWZLSFABNNENI-UHFFFAOYSA-N ;
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