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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/03 21:59:53」(JST)

Diclofenamide (or dichlorphenamide) is a sulfonamide and a carbonic anhydrase inhibitor of the meta-disulfamoylbenzene class.

Uses

Diclofenamide is used to treat glaucoma^[1]^[2] and therapy-resistant epilepsy.^[3]

^ International Drug Names: Diclofenamide
^ Kanski, J. J. (1968). "Carbonic anhydrase inhibitors and osmotic agents in glaucoma. Carbonic anhydrase inhibitors". The British journal of ophthalmology 52 (8): 642–643. doi:10.1136/bjo.52.8.642. PMC 506660. PMID 5724852. edit
^ Rucquoy, M.; Sorel, L. (1978). "Diclofenamide in the treatment of therapy-resistant epilepsy". Acta neurologica Belgica 78 (3): 174–182. PMID 352085. edit

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Emerging role of calcium-activated potassium channel in the regulation of cell viability following potassium ions challenge in HEK293 cells and pharmacological modulation.

Tricarico D1, Mele A, Calzolaro S, Cannone G, Camerino GM, Dinardo MM, Latorre R, Conte Camerino D.
PloS one.PLoS One.2013 Jul 16;8(7):e69551. doi: 10.1371/journal.pone.0069551. Print 2013.
Emerging evidences suggest that Ca(2+)activated-K(+)-(BK) channel is involved in the regulation of cell viability. The changes of the cell viability observed under hyperkalemia (15 mEq/L) or hypokalemia (0.55 mEq/L) conditions were investigated in HEK293 cells expressing the hslo subunit (hslo-HEK29
PMID 23874973

Methazolamide is a new hepatic insulin sensitizer that lowers blood glucose in vivo.

Konstantopoulos N1, Molero JC, McGee SL, Spolding B, Connor T, de Vries M, Wanyonyi S, Fahey R, Morrison S, Swinton C, Jones S, Cooper A, Garcia-Guerra L, Foletta VC, Krippner G, Andrikopoulos S, Walder KR.
Diabetes.Diabetes.2012 Aug;61(8):2146-54. doi: 10.2337/db11-0578. Epub 2012 May 14.
We previously used Gene Expression Signature technology to identify methazolamide (MTZ) and related compounds with insulin sensitizing activity in vitro. The effects of these compounds were investigated in diabetic db/db mice, insulin-resistant diet-induced obese (DIO) mice, and rats with streptozot
PMID 22586591

Evaluation of the therapeutic potential of carbonic anhydrase inhibitors in two animal models of dystrophin deficient muscular dystrophy.

Giacomotto J1, Pertl C, Borrel C, Walter MC, Bulst S, Johnsen B, Baillie DL, Lochmüller H, Thirion C, Ségalat L.
Human molecular genetics.Hum Mol Genet.2009 Nov 1;18(21):4089-101. doi: 10.1093/hmg/ddp358. Epub 2009 Jul 31.
Duchenne Muscular Dystrophy is an inherited muscle degeneration disease for which there is still no efficient treatment. However, compounds active on the disease may already exist among approved drugs but are difficult to identify in the absence of cellular models. We used the Caenorhabditis elegans
PMID 19648295

Diclofenamide
Systematic (IUPAC) name
	4,5-dichlorobenzene-1,3-disulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601233
Pharmacokinetic data
Protein binding	55%
Identifiers
CAS Registry Number	120-97-8
ATC code	S01EC02
PubChem	CID: 3038
IUPHAR/BPS	6807
DrugBank	DB01144
ChemSpider	2930
UNII	VVJ6673MHY
KEGG	D00518
ChEBI	CHEBI:101085
ChEMBL	CHEMBL17
Chemical data
Formula	C6H6Cl2N2O4S2
Molecular mass	305.16 g/mol
	SMILES Clc1c(cc(cc1Cl)S(=O)(=O)N)S(=O)(=O)N ;
	InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) ; Key:GJQPMPFPNINLKP-UHFFFAOYSA-N ;
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