シクロバルビタール
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/03/15 21:42:33」(JST)
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Cyclobarbital
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
Oral (tablets) |
ATC code |
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Legal status |
Legal status |
- CA: Schedule IV
- DE: Anlage II (Authorized trade only, not prescriptible)
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Pharmacokinetic data |
Metabolism |
Hepatic |
Excretion |
Renal |
Identifiers |
IUPAC name
- 5-(1-cyclohexenyl)-5-ethyl-1,3-diazinane-2,4,6-trione
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CAS Number |
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PubChem CID |
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ChemSpider |
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UNII |
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KEGG |
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ChEMBL |
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ECHA InfoCard |
100.000.127 |
Chemical and physical data |
Formula |
C12H16N2O3 |
Molar mass |
236.267 g/mol |
3D model (JSmol) |
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SMILES
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O=C1NC(=O)NC(=O)C1(/C2=C/CCCC2)CC
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InChI
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InChI=1S/C12H16N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h6H,2-5,7H2,1H3,(H2,13,14,15,16,17) Y
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Key:WTYGAUXICFETTC-UHFFFAOYSA-N Y
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NY (what is this?) (verify) |
Cyclobarbital, also known as cyclobarbitol or cyclobarbitone, is a drug which is a barbiturate derivative.[1] It is primarily available in fixed-dose combination with diazepam under the brand name Reladorm (100 mg cyclobarbital + 10 mg diazepam) and is used to treat insomnia in Russia.[2]
References
- ^ Breimer, D. D.; Winten, M. A. (1976). "Pharmacokinetics and relative bioavailability of cyclobarbital calcium in man after oral administration". European journal of clinical pharmacology. 09 (5–6): 443–450. PMID 989475.
- ^ "Russian State Register of Medicines. Registration Certificate: Reladorm (diazepam + cyclobarbital). Revised 02 Sep 2013" (in Russian). Retrieved 6 March 2016.
Hypnotics/sedatives (N05C)
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GABAA |
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GABAB |
- 1,4-Butanediol
- 4-Fluorophenibut
- Aceburic acid
- Baclofen
- GABOB
- GHB (sodium oxybate)
- GBL
- GVL
- Phenibut
- Tolibut
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H1 |
Antihistamines |
- Captodiame
- Cyproheptadine
- Diphenhydramine
- Doxylamine
- Hydroxyzine
- Methapyrilene
- Perlapine
- Pheniramine
- Promethazine
- Propiomazine
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Antidepressants |
- Serotonin antagonists and reuptake inhibitors
- Etoperidone
- Nefazodone
- Trazodone
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
- Mianserin
- Mirtazapine, etc.
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Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
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α2-Adrenergic |
- Clonidine
- Detomidine
- Dexmedetomidine
- Lofexidine
- Medetomidine
- Romifidine
- Tizanidine
- Xylazine
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5-HT2A |
Antidepressants |
- Trazodone
- Tricyclic antidepressants
- Amitriptyline
- Doxepin
- Trimipramine, etc.
- Tetracyclic antidepressants
- Mianserin
- Mirtazapine, etc.
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Antipsychotics |
- Typical antipsychotics
- Chlorpromazine
- Thioridazine, etc.
- Atypical antipsychotics
- Olanzapine
- Quetiapine
- Risperidone, etc.
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Others |
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Melatonin |
- Agomelatine
- Melatonin
- Ramelteon
- Tasimelteon
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Orexin |
- Almorexant
- Filorexant
- Suvorexant
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α2δ VDCC |
- Gabapentin
- Gabapentin enacarbil
- Mirogabalin
- Phenibut
- Pregabalin
|
Others |
- Cannabidiol
- Chlorophenylalkyldiols
- Fenpentadiol
- Metaglycodol
- Phenaglycodol
- Diethylpropanediol
- Evoxine
- Fenadiazole
- Guaifenesin-related muscle relaxants
- Chlorphenesin
- Mephenesin
- Mephenoxalone
- Metaxalone
- Methocarbamol
- Opioids (e.g., morphine)
- Passion flower
- Scopolamine
- Trazodone
- UMB68
- Valnoctamide
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GABAA receptor positive modulators
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Alcohols |
- Brometone
- Butanol
- Chloralodol
- Chlorobutanol (cloretone)
- Ethanol (alcohol) (alcoholic drink)
- Ethchlorvynol
- Isobutanol
- Isopropanol
- Menthol
- Methanol
- Methylpentynol
- Pentanol
- Petrichloral
- Propanol
- tert-Butanol (2M2P)
- tert-Pentanol (2M2B)
- Tribromoethanol
- Trichloroethanol
- Triclofos
- Trifluoroethanol
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Barbiturates |
- (-)-DMBB
- Allobarbital
- Alphenal
- Amobarbital
- Aprobarbital
- Barbexaclone
- Barbital
- Benzobarbital
- Benzylbutylbarbiturate
- Brallobarbital
- Brophebarbital
- Butabarbital/Secbutabarbital
- Butalbital
- Buthalital
- Butobarbital
- Butallylonal
- Carbubarb
- Crotylbarbital
- Cyclobarbital
- Cyclopentobarbital
- Difebarbamate
- Enallylpropymal
- Ethallobarbital
- Eterobarb
- Febarbamate
- Heptabarb
- Heptobarbital
- Hexethal
- Hexobarbital
- Metharbital
- Methitural
- Methohexital
- Methylphenobarbital
- Narcobarbital
- Nealbarbital
- Pentobarbital
- Phenallymal
- Phenobarbital
- Phetharbital
- Primidone
- Probarbital
- Propallylonal
- Propylbarbital
- Proxibarbital
- Reposal
- Secobarbital
- Sigmodal
- Spirobarbital
- Talbutal
- Tetrabamate
- Tetrabarbital
- Thialbarbital
- Thiamylal
- Thiobarbital
- Thiobutabarbital
- Thiopental
- Thiotetrabarbital
- Valofane
- Vinbarbital
- Vinylbital
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Benzodiazepines |
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Carbamates |
- Carisbamate
- Carisoprodol
- Clocental
- Cyclarbamate
- Difebarbamate
- Emylcamate
- Ethinamate
- Febarbamate
- Felbamate
- Hexapropymate
- Lorbamate
- Mebutamate
- Meprobamate
- Nisobamate
- Pentabamate
- Phenprobamate
- Procymate
- Styramate
- Tetrabamate
- Tybamate
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Flavonoids |
- 6-Methylapigenin
- Ampelopsin (dihydromyricetin)
- Apigenin
- Baicalein
- Baicalin
- Catechin
- EGC
- EGCG
- Hispidulin
- Linarin
- Luteolin
- Rc-OMe
- Skullcap constituents (e.g., baicalin)
- Wogonin
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Imidazoles |
- Etomidate
- Metomidate
- Propoxate
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Kava constituents |
- 10-Methoxyyangonin
- 11-Methoxyyangonin
- 11-Hydroxyyangonin
- Desmethoxyyangonin
- 11-Methoxy-12-hydroxydehydrokavain
- 7,8-Dihydroyangonin
- Kavain
- 5-Hydroxykavain
- 5,6-Dihydroyangonin
- 7,8-Dihydrokavain
- 5,6,7,8-Tetrahydroyangonin
- 5,6-Dehydromethysticin
- Methysticin
- 7,8-Dihydromethysticin
- Yangonin
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Monoureides |
- Acecarbromal
- Apronal (apronalide)
- Bromisoval
- Carbromal
- Capuride
- Ectylurea
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Neuroactive steroids |
- Acebrochol
- Allopregnanolone (brexanolone)
- Alfadolone
- Alfaxalone
- 3α-Androstanediol
- Androstenol
- Androsterone
- Certain anabolic-androgenic steroids
- Cholesterol
- DHDOC
- 3α-DHP
- 5α-DHP
- 5β-DHP
- DHT
- Etiocholanolone
- Ganaxolone
- Hydroxydione
- Minaxolone
- ORG-20599
- ORG-21465
- P1-185
- Pregnanolone (eltanolone)
- Progesterone
- Renanolone
- SAGE-105
- SAGE-217
- SAGE-324
- SAGE-516
- SAGE-689
- SAGE-872
- Testosterone
- THDOC
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Nonbenzodiazepines |
- β-Carbolines: Abecarnil
- Gedocarnil
- Harmane
- SL-651,498
- ZK-93423
- Cyclopyrrolones: Eszopiclone
- Pagoclone
- Pazinaclone
- Suproclone
- Suriclone
- Zopiclone
- Imidazopyridines: Alpidem
- DS-1
- Necopidem
- Saripidem
- Zolpidem
- Pyrazolopyrimidines: Divaplon
- Fasiplon
- Indiplon
- Lorediplon
- Ocinaplon
- Panadiplon
- Taniplon
- Zaleplon
- Others: Adipiplon
- CGS-8216
- CGS-9896
- CGS-13767
- CGS-20625
- CL-218,872
- CP-615,003
- CTP-354
- ELB-139
- GBLD-345
- Imepitoin
- JM-1232
- L-838,417
- Lirequinil (Ro41-3696)
- NS-2664
- NS-2710
- NS-11394
- Pipequaline
- ROD-188
- RWJ-51204
- SB-205,384
- SX-3228
- TGSC01AA
- TP-003
- TPA-023
- TP-13
- U-89843A
- U-90042
- Viqualine
- Y-23684
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Phenols |
- Fospropofol
- Propofol
- Thymol
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Piperidinediones |
- Glutethimide
- Methyprylon
- Piperidione
- Pyrithyldione
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Pyrazolopyridines |
- Cartazolate
- Etazolate
- ICI-190,622
- Tracazolate
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Quinazolinones |
- Afloqualone
- Cloroqualone
- Diproqualone
- Etaqualone
- Mebroqualone
- Mecloqualone
- Methaqualone
- Methylmethaqualone
- Nitromethaqualone
- SL-164
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Volatiles/gases |
- Acetone
- Acetophenone
- Acetylglycinamide chloral hydrate
- Aliflurane
- Benzene
- Butane
- Butylene
- Centalun
- Chloral
- Chloral betaine
- Chloral hydrate
- Chloroform
- Cryofluorane
- Desflurane
- Dichloralphenazone
- Dichloromethane
- Diethyl ether
- Enflurane
- Ethyl chloride
- Ethylene
- Fluroxene
- Gasoline
- Halopropane
- Halothane
- Isoflurane
- Kerosine
- Methoxyflurane
- Methoxypropane
- Nitric oxide
- Nitrogen
- Nitrous oxide
- Norflurane
- Paraldehyde
- Propane
- Propylene
- Roflurane
- Sevoflurane
- Synthane
- Teflurane
- Toluene
- Trichloroethane (methyl chloroform)
- Trichloroethylene
- Vinyl ether
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Others/unsorted |
- 3-Hydroxybutanal
- α-EMTBL
- AA-29504
- Avermectins (e.g., ivermectin)
- Bromide compounds (e.g., lithium bromide, potassium bromide, sodium bromide)
- Carbamazepine
- Chloralose
- Chlormezanone
- Clomethiazole
- DEABL
- Dihydroergolines (e.g., dihydroergocryptine, dihydroergosine, dihydroergotamine, ergoloid (dihydroergotoxine))
- DS2
- Efavirenz
- Etazepine
- Etifoxine
- Fenamates (e.g., flufenamic acid, mefenamic acid, niflumic acid, tolfenamic acid)
- Fluoxetine
- Flupirtine
- Hopantenic acid
- Lanthanum
- Lavender oil
- Lignans (e.g., 4-O-methylhonokiol, honokiol, magnolol, obovatol)
- Loreclezole
- Menthyl isovalerate (validolum)
- Monastrol
- Niacin
- Nicotinamide (niacinamide)
- Org 25,435
- Phenytoin
- Propanidid
- Retigabine (ezogabine)
- Safranal
- Seproxetine
- Stiripentol
- Sulfonylalkanes (e.g., sulfonmethane (sulfonal), tetronal, trional)
- Terpenoids (e.g., borneol)
- Topiramate
- Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol)
- Unsorted benzodiazepine site positive modulators: α-Pinene
- MRK-409 (MK-0343)
- TCS-1105
- TCS-1205
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See also: Receptor/signaling modulators • GABA receptor modulators • GABA metabolism/transport modulators
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English Journal
- Determination of acidic and neutral therapeutic drugs in human blood by liquid chromatography-electrospray tandem mass spectrometry.
- Sørensen LK1.
- Forensic science international.Forensic Sci Int.2011 Mar 20;206(1-3):119-26. doi: 10.1016/j.forsciint.2010.07.016. Epub 2010 Aug 12.
- PMID 20708359
- Molecularly imprinted polymers for simultaneous determination of antiepileptics in river water samples by liquid chromatography-tandem mass spectrometry.
- Hoshina K1, Horiyama S, Matsunaga H, Haginaka J.
- Journal of chromatography. A.J Chromatogr A.2009 Jun 19;1216(25):4957-62. doi: 10.1016/j.chroma.2009.04.071. Epub 2009 May 3.
- PMID 19439306
- Comparison of the percutaneous absorption of hydrophilic and lipophilic compounds in shed snake skin and human skin.
- Ngawhirunpat T1, Panomsuk S, Opanasopit P, Rojanarata T, Hatanaka T.
- Die Pharmazie.Pharmazie.2006 Apr;61(4):331-5.
- PMID 16649549
Japanese Journal
- Preparation of Magnetic Molecularly Imprinted Polymer for Cyclobarbital and Its Application to the Assay of Phenobarbital in Human Serum
- Preparation of Magnetic Molecularly Imprinted Polymer for Cyclobarbital and Its Application to the Assay of Phenobarbital in Human Serum
- Effects of Absorption Enhancers and Lipid Composition on Drug Permeability through the Model Membrane Using Stratum Corneum Lipids
Related Links
- Cyclobarbital | C12H16N2O3 | CID 5838 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. ... A chemical ...
- [Cyclobarbital] [52-31-3] | 価格や在庫、物性値などの詳細情報ページです。 ... 絵表示 注意喚起語 警告 危険有害性情報 H302:飲み込むと有害 注意書き P264:取扱い後は手や顔をよく洗うこと。 P270
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