WordNet

English Journal

Discovery of D1 Dopamine Receptor Positive Allosteric Modulators: Characterization of Pharmacology and Identification of Residues that Regulate Species Selectivity.

Lewis MA1, Hunihan L1, Watson J1, Gentles RG1, Hu S1, Huang Y1, Bronson J1, Macor JE1, Beno BR1, Ferrante M1, Hendricson A1, Knox RJ1, Molski TF1, Kong Y1, Cvijic ME1, Rockwell KL1, Weed MR1, Cacace AM1, Westphal RS1, Alt A1, Brown JM2.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2015 Sep;354(3):340-9. doi: 10.1124/jpet.115.224071. Epub 2015 Jun 24.
The present studies represent the first published report of a dopamine D1 positive allosteric modulator (PAM). D1 receptors have been proposed as a therapeutic target for the treatment of cognitive deficits associated with schizophrenia. However, the clinical utility of orthosteric agonist compounds
PMID 26109678

Toward Naphthocyclinones: Doubly Connected Octaketide Dimers with a Bicyclo[3.2.1]octadienone Core by Thiolate-Mediated Cyclization.

Ando Y1, Hori S1, Fukazawa T1, Ohmori K2, Suzuki K3.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2015 Aug 10;54(33):9650-3. doi: 10.1002/anie.201503442. Epub 2015 Jun 26.
A viable method is reported for the synthesis of the bicyclo[3.2.1]octadienone scaffold in naturally occurring octaketide dimers. The procedure employs a reductive cyclization reaction mediated by an unusual ethanedithiol monosodium salt. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PMID 26118656

Ting CP, Maimone TJ.
Journal of the American Chemical Society.J Am Chem Soc.2015 Aug 7. [Epub ahead of print]
A ten-step total synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) natural product hyperforin is reported from 2-methylcyclopent-2-en-1-one. This route was enabled by a diketene annulation reaction and oxidative ring expansion strategy designed to complement the presumed biosynthe
PMID 26252484

Selected Paper : Computational Study of Cyclobutane-1,3-diylidene Dicarbenes : Ground-State Spin Multiplicity and New Strategy toward the Synthesis of Bicyclo[1.1.0]but-1(3)-enes

Computational Study of Cyclobutane-1,3-diylidene Dicarbenes: Ground-State Spin Multiplicity and New Strategy Toward the Synthesis of Bicyclo[1.1.0]but-1(3)-enes