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Effects of prolonged selective serotonin reuptake inhibition on the development and expression of L-DOPA-induced dyskinesia in hemi-parkinsonian rats.

Conti MM1, Ostock CY2, Lindenbach D3, Goldenberg AA4, Kampton E5, Dell'isola R6, Katzman AC7, Bishop C8.
Neuropharmacology.Neuropharmacology.2014 Feb;77:1-8. doi: 10.1016/j.neuropharm.2013.09.017. Epub 2013 Sep 22.
Dopamine (DA) replacement therapy with l-DOPA is the standard treatment for Parkinson's disease (PD). Unfortunately chronic treatment often leads to the development of abnormal involuntary movements (AIMs) referred to as L-DOPA-induced dyskinesia (LID). Accumulating evidence has shown that compensat
PMID 24067924

Dopamine receptor activation increases glial cell line-derived neurotrophic factor in experimental stroke.

Kuric E1, Wieloch T, Ruscher K.
Experimental neurology.Exp Neurol.2013 Sep;247:202-8. doi: 10.1016/j.expneurol.2013.04.016. Epub 2013 May 9.
Treatment with levodopa enhances functional recovery after experimental stroke but its mechanisms of action are elusive. Reactive astrocytes in the ischemic hemisphere are involved in mechanisms promoting recovery and also express dopamine 1 (D1) and dopamine 2 (D2) receptors. Here we investigated i
PMID 23664961

Exercise attenuates levodopa-induced dyskinesia in 6-hydroxydopamine-lesioned mice.

Aguiar AS Jr1, Moreira EL, Hoeller AA, Oliveira PA, Córdova FM, Glaser V, Walz R, Cunha RA, Leal RB, Latini A, Prediger RD.
Neuroscience.Neuroscience.2013 Jul 23;243:46-53. doi: 10.1016/j.neuroscience.2013.03.039. Epub 2013 Apr 1.
L-DOPA alleviates the motor symptoms of Parkinson's disease, but its long-term use is associated with undesirable dyskinesia. We now tested whether exercise can attenuate this L-DOPA-induced dyskinesia (LID). We tested the effects of exercise on LID in 6-hydroxydopamine hydrochloride-hemiparkinsonia
PMID 23558088