English Journal

Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent.

Giustarini D1, Fanti P2, Sparatore A3, Matteucci E4, Rossi R5.
Biochemical pharmacology.Biochem Pharmacol.2014 May 15;89(2):246-54. doi: 10.1016/j.bcp.2014.03.005. Epub 2014 Mar 14.
High homocysteine (Hcys) levels are suspected to contribute to the pathogenesis of cardiovascular disease and of other chronic conditions. Failure of B vitamins to reduce the incidence of cardiovascular events while lowering the Hcys levels, has prompted the search for alternative treatments. We tes
PMID 24637238

An examination of the potential effect of lipids on the first-pass metabolism of the lipophilic drug anethol trithione.

Yu HZ1, Han SF, Li P, Zhu CL, Zhang XX, Gan L, Gan Y.
Journal of pharmaceutical sciences.J Pharm Sci.2011 Nov;100(11):5048-58. doi: 10.1002/jps.22702. Epub 2011 Jul 15.
In this study, an examination of the potential effect of lipids on the first-pass metabolism of anethol trithione (ATT) was investigated. ATT is metabolized rapidly and extensively in liver into 4-hydroxy-anethole trithione (ATX), which was confirmed using the rat intestinal perfusion with the mesen
PMID 21766311

An HPLC-MS/MS method for the quantitative determination of 4-hydroxy-anethole trithione in human plasma and its application to a pharmacokinetic study.

He J1, Qin T, Wen J, Qin F, Li F.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2011 Feb 20;54(3):551-6. doi: 10.1016/j.jpba.2010.09.037. Epub 2010 Oct 8.
A selective, rapid and sensitive method for the quantitation of 4-hydroxy-anethole trithione (ATX) in human plasma based on high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was developed and validated. Paracetamol was used as the internal standard (I.S.). After liquid-liq
PMID 20980118