- a central nervous system stimulant that increases energy and decreases appetite; used to treat narcolepsy and some forms of depression (同)pep_pill, upper, speed
- an amphetamine derivative (trade name Methedrine) used in the form of a crystalline hydrochloride; used as a stimulant to the nervous system and as an appetite suppressant (同)methamphetamine_hydrochloride, Methedrine, meth, deoxyephedrine, chalk, chicken_feed, crank, glass, ice, shabu, trash
- a sulfate derivative of amphetamine that is used as a stimulant for the central nervous system (同)amphetamine sulphate
- an isomer of amphetamine (trade name Dexedrine) used as a central nervous system stimulant (同)Dexedrine
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- Using population screening for recruitment of young adults engaged in illicit drug use: Methodological issues and sampling outcomes.
- Smirnov A1, Kemp R2, Wells H3, Legosz M3, Najman JM4.Author information 1Queensland Alcohol and Drug Research and Education Centre, School of Population Health, The University of Queensland, Herston Rd, Herston, QLD 4006, Australia; Drug Harm Reduction Branch, Health Protection Directorate, Queensland Health, Division of the Chief Health Officer, Butterfield St, Herston, QLD 4006, Australia. Electronic address: email@example.comDrug Harm Reduction Branch, Health Protection Directorate, Queensland Health, Division of the Chief Health Officer, Butterfield St, Herston, QLD 4006, Australia.3Crime and Misconduct Commission, North Tower Green Square, St. Pauls Terrace, Fortitude Valley, QLD 4006, Australia.4Queensland Alcohol and Drug Research and Education Centre, School of Population Health, The University of Queensland, Herston Rd, Herston, QLD 4006, Australia; School of Social Science, The University of Queensland, St. Lucia, QLD 4072, Australia.AbstractSocial stigma, legal sanctions and the associated lack of sampling frames create barriers to the probabilistic sampling of those engaged in a variety of behaviour, including illicit drug use. We used a novel sampling approach to recruit respondents into a longitudinal study examining amphetamine-type stimulant use. A young adult population was screened for lifetime drug use to create a sampling frame of amphetamine-type stimulant users and non-users. We posted 12,118 screening questionnaires to a random selection of young adults listed on the electoral roll for Brisbane and the Gold Coast, Australia (N=107,275). Using a small pre-paid incentive and intensive telephone and postal reminders we attained a screening response rate of 49.9%. Eligible amphetamine-type stimulant users (used ecstasy or methamphetamine⩾3 times in past 12months) and non-users (never used ecstasy or methamphetamine) were identified by screening responses. About two-thirds of each selected group took part in the longitudinal study. Comparisons with large-scale population survey data suggest the sample was broadly representative of young adult amphetamine-type stimulant users in Australia.
- Social science research.Soc Sci Res.2014 May;45:89-97. doi: 10.1016/j.ssresearch.2014.01.003. Epub 2014 Jan 16.
- Social stigma, legal sanctions and the associated lack of sampling frames create barriers to the probabilistic sampling of those engaged in a variety of behaviour, including illicit drug use. We used a novel sampling approach to recruit respondents into a longitudinal study examining amphetamine-typ
- PMID 24576629
- Effects of amphetamine exposure in adolescence or young adulthood on inhibitory control in adult male and female rats.
- Hammerslag LR1, Waldman AJ2, Gulley JM3.Author information 1Neuroscience Program, University of Illinois, Urbana-Champaign, USA.2Department of Psychology, University of Illinois, Urbana-Champaign, USA.3Neuroscience Program, University of Illinois, Urbana-Champaign, USA; Department of Psychology, University of Illinois, Urbana-Champaign, USA. Electronic address: firstname.lastname@example.org.AbstractHeightened impulsivity is a feature of some psychiatric disorders, including addiction, that also have sex-specific patterns of expression. The relationship between addiction and impulsivity may be driven by drug-induced changes in behavior caused by long term adaptations in signaling within the medial prefrontal cortex (mPFC). Here, we used a response inhibition task that is sensitive to changes in mPFC function to examine the effects of sex and exposure to amphetamine (AMPH) on impulsive action and vigilance. We also examined drug-induced alterations in glutamatergic and dopaminergic signaling through challenge injections with the NMDA receptor antagonist MK-801 (dizocilpine) and AMPH. Male and female Sprague Dawley rats were injected (i.p.) with saline or 3mg/kg AMPH every other day during adolescence (postnatal day (P) 27-45) or adulthood (P85-103). Starting on P125-135, rats were tested for their ability to lever press for a food reward during periods of signaled availability and withhold responding during a "premature response" phase. In experiment 1, rats received challenge injections (i.p.) of MK-801 and AMPH followed by tests of task performance and locomotor activity. In experiment 2, rats received intra-mPFC infusion of MK-801. We found that females had better inhibitory control and poorer vigilance than males and that AMPH exposure had both sex- and age-of-exposure dependent effects on impulsivity. Systemic drug challenges disrupted task performance, particularly in females, and increased impulsivity while intra-mPFC infusions had modest effects. AMPH exposure did not affect responses to drug challenges. Together, these results suggest that sex mediates both trait and drug-induced impulsivity.
- Behavioural brain research.Behav Brain Res.2014 Apr 15;263:22-33. doi: 10.1016/j.bbr.2014.01.015. Epub 2014 Jan 22.
- Heightened impulsivity is a feature of some psychiatric disorders, including addiction, that also have sex-specific patterns of expression. The relationship between addiction and impulsivity may be driven by drug-induced changes in behavior caused by long term adaptations in signaling within the med
- PMID 24462963
- Analysis of amphetamine-type substances and piperazine analogues using desorption electrospray ionisation mass spectrometry.
- Stojanovska N1, Kelly T, Tahtouh M, Beavis A, Fu S.Author information 1Centre for Forensic Science, University of Technology, Sydney (UTS), PO Box 123, Broadway, NSW, 2007, Australia.AbstractRATIONALE: Although amphetamine-type substances (ATS) have been investigated extensively in recent years, scarce data is available on screening tests for piperazine analogues. The need for a universal technique capable of detecting an extensive range of drug compounds becomes increasingly important with the continued emergence of novel drug analogues.
- Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2014 Apr 15;28(7):731-40. doi: 10.1002/rcm.6832.
- RATIONALE: Although amphetamine-type substances (ATS) have been investigated extensively in recent years, scarce data is available on screening tests for piperazine analogues. The need for a universal technique capable of detecting an extensive range of drug compounds becomes increasingly important
- PMID 24573804
- Exercise modifies amphetamine relapse: Behavioral and oxidative markers in rats.
- Segat HJ1, Kronbauer M1, Roversi K2, Schuster AJ2, Vey LT2, Roversi K2, Pase CS3, Antoniazzi CT3, Burger ME4.Author information 1Programa de Pós-Graduação em Bioquímica Toxicológica-Universidade Federal de Santa Maria-UFSM-RS, Brazil.2Departamento de Fisiologia e Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.3Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil.4Programa de Pós-Graduação em Bioquímica Toxicológica-Universidade Federal de Santa Maria-UFSM-RS, Brazil; Programa de Pós-Graduação em Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil; Departamento de Fisiologia e Farmacologia-Universidade Federal de Santa Maria-UFSM-RS, Brazil. Electronic address: email@example.com.AbstractExercise has been reported to attenuate rewarding symptoms related to addictive drugs mainly by affecting the brain neuroplasticity and neurotransmission. In this study, we investigated the influence of physical exercise on the behavioral and enzymatic status related to drug relapse in rats. Animals were primarily treated with amphetamine (AMPH; 4.0mg/kg, i.p.) or vehicle (C; NaCl 0.9% solution) in the conditioned place preference (CPP) paradigm for 14 days. Half of each experimental group was then submitted to swimming sessions (60min/day, 5 days/week) for 5 weeks. Animals were re-exposed to AMPH- or vehicle-CPP paradigm for another 3 days, in order to observe drug relapse and anxiety-like symptoms, which were observed 24h after AMPH reconditioning in CPP, and elevated plus maze (EPM), respectively, and brain biochemical evaluations were carried out subsequently. While AMPH was related to place preference and anxiety, indicating drug addiction and abstinence symptoms, respectively, physical activity was able to prevent relapse symptoms after AMPH reconditioning, as observed through consecutive decreased CPP and anxiety-like symptoms. In addition, AMPH exposure increased reactive species (RS) generation and protein carbonyl (PC) levels together with decreased activity of catalase- and Na(+)K(+)-ATPase in hippocampus. On the other hand, while all AMPH-induced effects were prevented by physical activity, there was a negative correlation between PC levels (r=0.65; p<0.003) and CAT activity, and a positive correlation between RS generation and PC levels (r=0.54; r=0.52, p<0.05) with AMPH-CPP after exercise. These results indicate that exercise has a clear beneficial influence on the prevention of psychostimulant drug relapse.
- Behavioural brain research.Behav Brain Res.2014 Apr 1;262:94-100. doi: 10.1016/j.bbr.2014.01.005. Epub 2014 Jan 18.
- Exercise has been reported to attenuate rewarding symptoms related to addictive drugs mainly by affecting the brain neuroplasticity and neurotransmission. In this study, we investigated the influence of physical exercise on the behavioral and enzymatic status related to drug relapse in rats. Animals
- PMID 24445072
- The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson's disease
- Tayra Judith Thomas,Kameda Masahiro,Yasuhara Takao,Agari Takashi,Kadota Tomohito,Wang Feifei,Kikuchi Yoichiro,Liang Hanbai,Shinko Aiko,Wakamori Takaaki,Vcelar Brigitta,Weik Robert,Date Isao
- Brain Research 1502, 55-70, 2013-03-28
- … Behavioral evaluations consisted of rota-rod, cylinder and amphetamine-induced rotation tests. … In the neuroprotection experiment, the CEPO-Fc group demonstrated significant improvement compared with the EPO-Fc group on the amphetamine-induced rotation test throughout the four-week follow-up period. …
- NAID 120005324796
- Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice
- Duo Jin,Muramatsu Shin-ichi,Shimizu Nobuaki,Yokoyama Shigeru,Hirai Hirokazu,Yamada Kiyofumi,Liu Hong-Xiang,Higashida Chiharu,Hashii Minako,Higashida Akihiko,Asano Masahide,Ohkuma Shoji,Higashida Haruhiro
- Neurochemistry International 61(6), 907-912, 2012-11
- … Motor performance on the accelerating rotarod test and amphetamine-induced ipsilateral rotation were improved in the rescued mice coexpressing ATP6V0C. …
- NAID 120004966609
- Amphetamine Addiction Treatment Options - Various treatment options exist to help those who are addicted to amphetamines including dual diagnosis treatment, inpatient treatment and outpaitent care. 5 Common ...
- Amphetamine Drug Articles ... Description: Intranasal administration (or snorting) of amphetamine is not used in the therapeutic setting. However, snorting amphetamine is the second most reported route of administration.
- The Amphetamine Debate: The Use of Adderall, Ritalin and Related Drugs for Behavior Modification, Neuroenhancement and Anti-Aging Purposes (McFarland Health Topics) by Elaine A. Moore and Foreword by K. Scott Pacer M ...
- drug abuse, substance abuse
- 濫用 substance abuse：a pattern of abnormal substance use that leads to impairment of occupational, physical, or social functioning(BBS.73)
- 依存 substance dependence：ub stance abuse puls withdrawal symptoms, tolerance, or a pattern of repetitive use(BBS.73)
- 離脱 withdrawal：the development of physical or pschological symptoms after the reduction or cessation of intake of a substance(BBS.73)
- 耐性 tolerance：the need for increased amounts of the substance to achieve the same positive psychological effect(BBS.73)
- 交差耐性 cross-tolerance：the development of tolerance to one substance as the result of using another substance(BBS.73)
- cerntral nervous system stimulant, CNS stimulant