Leydig cell tumor

ライディッヒ細胞腫

WordNet

1. small room in which a monk or nun lives (同)cubicle
2. a device that delivers an electric current as the result of a chemical reaction (同)electric cell
3. a room where a prisoner is kept (同)jail cell, prison cell
4. (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
5. any small compartment; "the cells of a honeycomb"
6. a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
7. an abnormal new mass of tissue that serves no purpose (同)tumour, neoplasm

PrepTutorEJDIC

1. (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/04/10 02:14:59」(JST)

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Leydig cell tumour
Low magnification micrograph of a Leydig cell tumour. H&E stain.
Classification and external resources
ICD-9	183.0, 256.1
ICD-O:	8631
DiseasesDB	7445
MedlinePlus	000409
MeSH	D007984

Leydig cell tumour, also Leydig cell tumor (US spelling), (testicular) interstitial cell tumour and (testicular) interstitial cell tumor (US spelling), is a member of the sex cord-stromal tumour group of ovarian and testicular cancers. It arises from Leydig cells. While the tumour can occur at any age, it occurs most often in young adults.

A Sertoli-Leydig cell tumour is a combination of a Leydig cell tumour and a Sertoli cell tumour from Sertoli cells.

Presentation

The majority of Leydig cell tumors are found in men, usually at 5–10 years of age or in middle adulthood (30–60 years). Children typically present with precocious puberty. Due to excess testosterone secreted by the tumour, one-third of female patients present with a recent history of progressive masculinization. Masculinization is preceded by anovulation, oligomenorrhea, amenorrhea and defeminization. Additional signs include acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. Serum testosterone level is high. In men testicular swelling is the most common presenting feature, though gynecomastia may be the first symptom in some patients.

Diagnosis

Presence of an ovarian tumour plus hormonal disturbances suggests a Leydig cell tumour, granulosa cell tumour or thecoma. However, hormonal disturbances, in Leydig tumours, is present in only 2/3 of cases. A conclusive diagnosis is made via histology, as part of a pathology report made during or after surgery. Reinke crystals are classically found in these tumours and help confirm the diagnosis, although they are seen in less than half of all Leydig cell tumours. See also Sex cord-stromal tumour.

Immunohistochemical markers of Leydig cell tumours include inhibin-alpha, calretinin, and melan-A.

Treatment

The usual treatment is surgery. The surgery usually is a fertility-sparing unilateral salpingo-oophorectomy. For malignant tumours, the surgery may be radical and usually is followed by adjuvant chemotherapy, sometimes by radiation therapy. In all cases, initial treatment is followed by surveillance. Because in many cases Leydig cell tumour does not produce elevated tumour markers, the focus of surveillance is on repeated physical examination and imaging.

The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 10% are malignant. For malignant tumours with undifferentiated histology, prognosis is poor.

It is usually benign.

Additional images

• Intermediate magnification micrograph of a Leydig cell tumour. H&E stain.

• High magnification micrograph of a Leydig cell tumour. H&E stain.

See also

• Androgen-dependent syndromes
• Sertoli cell tumour
• Sertoli-Leydig cell tumour

References

UpToDate Contents

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• 1. 精巣性索間質腫瘍 testicular sex cord stromal tumors
• 2. 卵巣の性索間質腫瘍の概要 overview of sex cord stromal tumors of the ovary
• 3. 精巣腫瘍の解剖学および病理 anatomy and pathology of testicular tumors
• 4. 卵巣の性索間質腫瘍：顆粒膜細胞腫瘍およびセルトリ・ライディック細胞腫 sex cord stromal tumors of the ovary tumors with granulosa and sertoli leydig elements
• 5. 卵巣の性索間質腫瘍：セルトリ・間質細胞腫瘍 sex cord stromal tumors of the ovary sertoli stromal cell tumors

English Journal

• Ovarian sertoli-leydig cell tumor in a 9-month-old infant with special histologic pattern.

• Shu H, Yang XH, Gao AF.SourceDepartment of Pathology, Shengjing Hospital of China Medical University , Shenyang , China.
• Fetal and pediatric pathology.Fetal Pediatr Pathol.2012 Dec;31(6):388-93. doi: 10.3109/15513815.2012.659404. Epub 2012 Mar 23.
• A 9-month-old infant with left ovarian Sertoli Leydig cell tumors (SLCTs) was reported and the special histological pattern was that the main components of the tumor were leydig cells. She was the youngest reported case of the tumor. The patient had increased serum estradiol and A-Fetoprofein (AFP)
• PMID 22443217

Japanese Journal

• P2-3-4 インスリン抵抗性改善薬pioglitazone投与とダイエットが奏効したSertoli-Leydig cell tumor摘出後の2次性PCOS症例からの新知見(Group75 生殖医学(症例)3,一般演題,第63回日本産科婦人科学会学術講演会)

• 清水 亜由美,遠藤 俊明,長澤 邦彦,馬場 剛,高田 さくら,高橋 円,石岡 伸一,斎藤 豪
• 日本産科婦人科學會雜誌 63(2), 715, 2011-02-01
• NAID 110008509569

Related Links

• Leydig cell tumor: MedlinePlus Medical Encyclopedia

Causes The cause of this tumor is unknown. There are no known risk factors for getting this tumor. Unlike germ cell tumors of the testicles, this tumor does not seem to be linked to undescended testes (cryptorchidism). ...

• Leydig cell tumor - National Library of Medicine - PubMed Health

A Leydig cell tumor is a tumor of the testicle. It develops from Leydig cells -- the cells in the testicles that release the male hormone, testosterone. ... Causes, incidence, and risk factors The cause of this tumor is ...

Related Pictures

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★リンクテーブル★

リンク元	「ライディッヒ細胞腫」「門細胞腫」
拡張検索	「Sertoli-Leydig cell tumor」「Sertoli-Leydig cell tumors」「Leydig cell tumors」
関連記事	「tumor」「cell」

「ライディッヒ細胞腫」

　　[★]

英

Leydig cell tumor

同

Leydig細胞腫

関

セルトリ・ライディッヒ細胞腫、門細胞腫。精巣間質細胞、睾丸間質細胞、精巣間質細胞腫、睾丸間質細胞腫

「門細胞腫」

　　[★]

英

Leydig cell tumor

関

ライディッヒ細胞腫、Leydig細胞腫

「Sertoli-Leydig cell tumor」

　　[★] セルトリ・ライディッヒ細胞腫

「Sertoli-Leydig cell tumors」

　　[★] セルトリ・ライディッヒ細胞腫

「Leydig cell tumors」

　　[★] ライディッヒ細胞腫

「tumor」

　　[★]

• n.

• 腫瘍、腫瘤、腫脹

　

「cell」

　　[★] 細胞