Auer rods

アウエル小体

WordNet

1. a long thin implement made of metal or wood
2. any rod-shaped bacterium
3. a visual receptor cell that is sensitive to dim light (同)rod_cell, retinal rod

PrepTutorEJDIC

1. (木製・金属製などの)『棒,つえ』,さお;釣りざお / (刑罰に用いる)木のむち;《the ~》むち打ち,せっかん / ロッド(長さの単位;『5』1/2yards,約5m) / (目の)桿(かん)状体(弱い光にも感じる網膜細胞) / 《米俗》ピストル
2. goldの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/13 14:48:43」(JST)

wiki en

[Wiki en表示]

Bone marrow aspirate showing acute myeloid leukemia with Auer rods in several blasts

Auer rods are clumps of azurophilic granular material that form elongated needles seen in the cytoplasm of myeloid leukemic blasts. They can be seen in the leukemic blasts of acute myeloid leukemia with maturation and acute promyelocytic leukemia (respectively known as acute myeloid leukemia M2 and M3 in the FAB classification) and in high grade myelodysplastic syndromes and myeloproliferative syndromes. They are composed of fused lysosomes/primary neutrophilic granules and contain peroxidase, lysosomal enzymes, and large crystalline inclusions. Morphologically, the Auer "rods" come in all sizes and shapes. They have been described as needle-shapes with pointed ends (most common), comma-shapes, and diamond-shapes; others were long and rectangular. Occasional corkscrew forms and rare granular Auer bodies were also noted. More appropriately, they can be referred to as Auer bodies.

They are also used to distinguish the pre-leukemia myelodysplastic syndromes: refractory anemia with excess blasts 2 (which has Auer rods) from RAEB 1 (which does not). However, rare cases of RAEB1 show rare Auer rods, and when they do, they have a worse prognosis.

Eponym

These cytoplasmic inclusions are named for John Auer, a US physiologist (1875-1948).

However, they were first described in 1905 by a Canadian physician, Thomas McCrae, then at The Johns Hopkins Hospital, one year before Auer, as acknowledged in Auer's article. Both McCrae and Auer mistakenly thought that the cells containing the rods were lymphoblasts.

Additional images

References

External links

• Image at NIH/MedlinePlus
• Slides at wadsworth.org
• Image at University of Utah

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 急性骨髄性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute myeloid leukemia
• 2. 末梢血塗抹標本の評価 evaluation of the peripheral blood smear
• 3. 急性骨髄性白血病の分類 classification of acute myeloid leukemia
• 4. 急性前骨髄球性白血病の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of acute promyelocytic leukemia in adults
• 5. 骨髄穿刺塗抹標本の評価 evaluation of bone marrow aspirate smears

English Journal

• Auer rod like inclusions in reactive plasma cells in a case of acute myeloid leukemia.

• Pradhan S.
• Turkish journal of haematology : official journal of Turkish Society of Haematology.Turk J Haematol.2016 Apr 18. doi: 10.4274/tjh.2015.0399. [Epub ahead of print]
• A 61years old female presented with decreasing hemoglobin for past 6 months. She had a history of multiple transfusions in the recent past. Laboratory investigations showed: hemoglobin of 8.6 g/dL, total blood leukocyte count of 1.13 x109/L, and platelets of 80x109/L with presence of occasional circ
• PMID 27095070

• Microgranular acute promyelocytic leukemia presenting with leukopenia and an unusual immunophenotype.

• McDonnell MH1, Smith ET Jr2, Lipford EH3, Gerber JM4, Grunwald MR5.
• Hematology/oncology and stem cell therapy.Hematol Oncol Stem Cell Ther.2016 Jan 16. pii: S1658-3876(16)00006-6. doi: 10.1016/j.hemonc.2015.12.004. [Epub ahead of print]
• The microgranular variant (M3v) of acute promyelocytic leukemia (APL) is rare, and the diagnosis can be delayed due to variability in how this condition presents. M3v blasts often have folded nuclei, but unlike traditional APL blasts, they often possess faint granules without Auer rods. In addition,
• PMID 26806461

• A new transcriptional variant and small azurophilic granules in an acute promyelocytic leukemia case with NPM1/RARA fusion gene.

• Kikuma T1, Nakamachi Y2, Noguchi Y1, Okazaki Y1, Shimomura D3, Yakushijin K4, Yamamoto K4, Matsuoka H4, Minami H4, Itoh T5, Kawano S6.
• International journal of hematology.Int J Hematol.2015 Dec;102(6):713-8. doi: 10.1007/s12185-015-1857-2. Epub 2015 Sep 5.
• We report here the first case of NPM1/RARA-positive acute promyelocytic leukemia (APL) preceded by myeloid sarcoma (MS) in the vertebra. A 52-year-old man was diagnosed with MS, as the tumor cells were positive for myeloperoxidase and CD68 but negative for CD163. After treatment with steroids and ra
• PMID 26342691

Japanese Journal

• Persistent Hypoplastic Acute Promyelocytic Leukemia with a Novel Chromosomal Abnormality of 46, XY, t(15;17), t(9;11)(q13;p13)

• Journal of Clinical and Experimental Hematopathology 55(2), 71-76, 2015
• NAID 130005104669

• A case of myelodysplastic syndrome presenting with faggot-like cells

• International journal of hematology 97(4), 443-445, 2013-04-01
• NAID 10031168509

• 胸水細胞診が診断に有用であった顆粒球肉腫の1例

• 日本臨床細胞学会雑誌 49(5), 347-351, 2010-09-22
• NAID 10026670167

Related Links

• Where do you see Auer rods? - Pathology Student

Q. In which type of AML do you see the most Auer rods? A. Auer rods are elongated structures seen in malignant cells of the neutrophil lineage. Mostly, they are seen in myeloblasts - but you can see them in any stage ...

• Auer rods: MedlinePlus Medical Encyclopedia Image

Overview Note multiple Auer rods which are found only in acute myeloid leukemias, either myeloblastic or monoblastic. These rods consist of clumps of ... Updated by: Todd Gersten, MD, Hematology/Oncology, Florida ...

---

★リンクテーブル★

関連記事	「rods」「Au」

「rods」

　　[★]

同

eye

同

vision

同

eye

「Au」

　　[★]

金

関

gold、golden