単クローン性免疫グロブリン血症

英

monoclonal gammopathy MG

同

単クローン性高免疫グロブリン血症 monoclonal hyperimmunoglobulinemia、単クローン性高ガンマグロブリン血症 単クローン性高γグロブリン血症 monoclonal hypergammaglobulinemia、M蛋白血症 M proteinemia

関

高γグロブリン血症

• 080626 免疫学

Clasification WCH.2566

• monoclonal gammopathy of undetermined significance

• benign(IgG, IgA, IgD, IgM, and, rarely, free light chains)
• associated with neoplasms of cell types not known to produce M-proteins
• biclonal gammopathy
• idiopathic Nence Jones proteinuria

• malignant monoclonal gammopathies

• multiple myeloma (IgG, IgA, IgD, IgE, and free κ or λ light chains

• overt multiple myeloma
• smoldering multiple myeloma
• plasma cell leukemia
• nonsecretory myeloma
• IgD myeloma
• POEMS: polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (osteosclerotic myeloma)

• plasmacytoma

• solitary plsmacytoma of bone
• extramedullary plamacytoma

• malignant lymphoproliferative disorders

• Waldenstrom macroglobulinemia(promary maroglobulinemia)
• malignant lymphoma
• chronic lymphocytic leukemia or lymphoproliferative disorders

• heavy chain diseases

• γ heary chain disease
• α heary chain disease
• μ heary chain disease

• amyloidosis

• primary amyloidosis
• with multiple myeloma (secondary, localized, and familial amyloidosis with no M-protein)

frequency WCH.2567

• monoclonal gammopathy of underteermined significance: 62%
• multiple myeloma: 16%
• amyloidosis: 8%
• lymphoproliferative: 3%
• smoldering multiple myeloma: 4%
• solitary or extramedullary: 1%
• Walderstrom maroglobulinemia: 3%
• other: 3%