ゾフェノプリル
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- zofenopril calcium
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/10 13:26:42」(JST)
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Zofenopril
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Systematic (IUPAC) name |
(2S,4S)-1-[(2S)-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
Oral |
Identifiers |
CAS Number |
81872-10-8 Y |
ATC code |
C09AA15 |
PubChem |
CID 92400 |
IUPHAR/BPS |
6462 |
ChemSpider |
83422 N |
UNII |
290ZY759PI N |
KEGG |
D08688 Y |
ChEBI |
CHEBI:78539 N |
ChEMBL |
CHEMBL331378 N |
Chemical data |
Formula |
C22H23NO4S2 |
Molar mass |
429.552 g/mol |
SMILES
-
O=C(N2[C@H](C(=O)O)C[C@H](Sc1ccccc1)C2)[C@H](C)CSC(=O)c3ccccc3
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InChI
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InChI=1S/C22H23NO4S2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,25,26)/t15-,18+,19+/m1/s1 N
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Key:IAIDUHCBNLFXEF-MNEFBYGVSA-N N
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NY (what is this?) (verify) |
Zofenopril (also known as zofenoprilum [Latin]) is an angiotensin converting enzyme (ACE) inhibitor with cardioprotective properties indicated for the treatment of hypertension.[1]
In small studies, zofenopril appeared significantly more effective than the older antihypertensives atenolol and enalapril, and was associated with fewer adverse effects.[2][3]
Zofenoprilat — the active metabolite of zofenopril
References
- ^ Ambrosioni E (2007). "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". Am J Cardiovasc Drugs 7 (1): 17–24. doi:10.2165/00129784-200707010-00002. PMID 17355163.
- ^ Nilsson P (October 2007). "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Press Suppl 2: 25–30. PMID 18046976.
- ^ Mallion JM (October 2007). "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Press Suppl 2: 13–8. PMID 18046974.
Antihypertensives: agents acting on the renin–angiotensin system (C09)
|
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ACE inhibitors
("-pril") |
- Sulfhydryl-containing: Captopril
- Rentiapril
- Zofenopril
- Dicarboxylate-containing: Enalapril#
- Benazepril
- Cilazapril
- Delapril
- Imidapril
- Lisinopril (+HCT)
- Moexipril
- Perindopril
- Quinapril (+HCT)
- Ramipril
- Spirapril
- Temocapril
- Trandolapril
- Phosphonate-containing: Fosinopril (+HCT)
- Other/ungrouped: Alacepril
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|
AIIRAs/
("-sartan") |
- Azilsartan
- Candesartan
- Eprosartan
- Fimasartan
- Irbesartan
- Losartan (+HCT)
- Olmesartan (+amlodipine)
- Tasosartan§
- Telmisartan (+HCT)
- Valsartan (+HCT, +amlodipine, +sacubitril)
|
|
Renin inhibitors/
("-kiren") |
- Aliskiren (+amlodipine, +amlodipine and HCT)
- Remikiren§
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|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of the circulatory system
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|
Description |
- Anatomy
- Arteries
- head and neck
- arms
- chest
- abdomen
- legs
- Veins
- head and neck
- arms
- chest
- abdomen and pelvis
- legs
- Development
- Cells
- Physiology
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|
Disease |
- Congenital
- Neoplasms and cancer
- Lymphatic vessels
- Injury
- Vasculitis
- Other
- Symptoms and signs
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|
Treatment |
- Procedures
- Drugs
- beta blockers
- channel blockers
- diuretics
- nonsympatholytic vasodilatory antihypertensives
- peripheral vasodilators
- renin–angiotensin system
- sympatholytic antihypertensives
- vasoprotectives
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UpToDate Contents
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English Journal
- Derivative spectrophotometric method for simultaneous determination of zofenopril and fluvastatin in mixtures and pharmaceutical dosage forms.
- Stolarczyk M1, Maślanka A2, Apola A2, Rybak W2, Krzek J2.
- Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2015 Sep 5;148:66-71. doi: 10.1016/j.saa.2015.03.100. Epub 2015 Apr 2.
- Fast, accurate and precise method for the determination of zofenopril and fluvastatin was developed using spectrophotometry of the first (D1), second (D2), and third (D3) order derivatives in two-component mixtures and in pharmaceutical preparations. It was shown, that the developed method allows fo
- PMID 25863461
- Characterization of zofenoprilat as an inducer of functional angiogenesis through increased H2 S availability.
- Terzuoli E1, Monti M1, Vellecco V2, Bucci M2, Cirino G2, Ziche M1, Morbidelli L1.
- British journal of pharmacology.Br J Pharmacol.2015 Jun;172(12):2961-73. doi: 10.1111/bph.13101. Epub 2015 Mar 27.
- BACKGROUND AND PURPOSE: Hydrogen sulfide (H2 S), an endogenous volatile mediator with pleiotropic functions, promotes vasorelaxation, exerts anti-inflammatory actions and regulates angiogenesis. Previously, the SH-containing angiotensin-converting enzyme inhibitor (ACEI), zofenopril, was identified
- PMID 25631232
- Zofenopril attenuates injury induced by ischemia-reperfusion on rat ovary.
- Keskin Kurt R1, Dogan AC2, Dogan M3, Albayrak A4, Kurt SN3, Eren F3, Silfeler DB1, Karateke A1, Fadillioglu E3, Delibasi T5,6,7.
- The journal of obstetrics and gynaecology research.J Obstet Gynaecol Res.2015 Jun;41(6):926-31. doi: 10.1111/jog.12658. Epub 2014 Dec 29.
- AIM: The aim of the study was to investigate the effectiveness of zofenopril in an experimental model of ovarian torsion in rats with histologic and biochemical assessments.MATERIAL AND METHODS: Experimental procedures were performed on 35 female rats (Wistar albino). Rats were randomly divided into
- PMID 25546378
Japanese Journal
- Cardioprotective effects of zofenopril, a new angiotensin-converting enzyme inhibitor, on doxorubicin-induced cardiotoxicity in the rat
- The Lipophilic Properties of Angiotensin I-Converting Enzyme Inhibitors Do Not Influence Their Diffusion Through Cultured Endothelium
- Raasch Walter,Dendorfer Andreas,Ball Benedikt [他],DOMINIAK Peter
- The Japanese journal of pharmacology 81(4), 346-352, 1999-12-01
- … In contrast, the extraction coefficients of the parent substances showed marked differences in the following order of increasing lipophilia: enalapril=perindopril<captopril=ceranapril<ramipril<quinapril<HOE288=zofenopril<fosinopril<HOE065. …
- NAID 10008197565
- Effects of the early administration of zofenopril on onset and progression of congestive heart failure in patients with anterior wall acute myocardial infarction. The SMILE Study Investigators. Survival of Myocardial Infarction Long-term Evaluation
Related Links
- References for "Zofenopril" online, at universities and in literature... cyclopaedia.net ... Publication date: Available online 11 April 2013 Source:The American Journal of Cardiology A head-to-head evaluation of the effect of ramipril and Zofenopril ...
- Zofenopril Presentation Transcript Dr. Gustavo Ruiz Deza Jefe Unidad Coronaria HIGA Pte. Perón Avellaneda Jefe Servicio de Cardiología Sanatorio Bernal Bernal- Pcia. Buenos Aires Hipertensión ...
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