出典: meddic


Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/08/01 16:46:27」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.


  • Synthesis and Biological Evaluation of N-Aryl-5-Aryloxazol-2-Amine Derivatives as 5-Lipoxygenase Inhibitors.
  • Suh JH1, Yum EK, Cho YS.
  • Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).2015 Jun 3. [Epub ahead of print]
  • We describe the synthesis and biological evaluation of N-aryl-5-aryloxazol-2-amine derivatives that are able to inhibit 5-lipoxygenase (5-LOX), a key enzyme of leukotriene synthesis, for the treatment of inflammation-related diseases including asthma and rheumatoid arthritis. A novel structural moie
  • PMID 26040270
  • Genome-wide association study of leukotriene modifier response in asthma.
  • Dahlin A1, Litonjua A2, Irvin CG3, Peters SP4, Lima JJ5, Kubo M6, Tamari M6, Tantisira KG2.
  • The pharmacogenomics journal.Pharmacogenomics J.2015 Jun 2. doi: 10.1038/tpj.2015.34. [Epub ahead of print]
  • Heterogeneous therapeutic responses to leukotriene modifiers (LTMs) are likely due to variation in patient genetics. Although prior candidate gene studies implicated multiple pharmacogenetic loci, to date, no genome-wide association study (GWAS) of LTM response was reported. In this study, DNA and p
  • PMID 26031901
  • New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: compounds with an iron chelating potential.
  • von Koschitzky I1, Gerhardt H, Lämmerhofer M, Kohout M, Gehringer M, Laufer S, Pink M, Schmitz-Spanke S, Strube C, Kaiser A.
  • Amino acids.Amino Acids.2015 Jun;47(6):1155-66. doi: 10.1007/s00726-015-1943-z. Epub 2015 Feb 26.
  • Deoxyhypusine hydroxylase (DOHH) is a dinuclear iron enzyme required for hydroxylation of the aminobutyl side chain of deoxyhypusine in eukaryotic translation initiation factor 5A (eIF-5A), the second step in hypusine biosynthesis. DOHH has been recently identified in P. falciparum and P. vivax. Bot
  • PMID 25715757


  • Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice
  • Tsukumo Yukihito,Harada Daisuke,Manabe Haruhiko
  • Journal of pharmacological sciences 113(3), 255-262, 2010-07-20
  • … The severe scratching behavior was suppressed by the 5-lipoxygenase inhibitor zileuton and leukotriene B<SUB>4</SUB>–receptor antagonist ONO-4057, but not by the cysteinyl leukotriene–receptor antagonist montelukast. …
  • NAID 10029889358
  • Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice
  • Kuraishi Yasushi,Ohtsuka Eiji,Nakano Tasuku [他],KAWAI Sanae,ANDOH Tsugunobu,NOJIMA Hiroshi,KAMIMURA Kiyoshi
  • Journal of pharmacological sciences 105(1), 41-47, 2007-09-20
  • … The 5-lipoxygenase inhibitor zileuton (100 mg/kg), the 5-lipoxygenase activating peptide inhibitor MK-886 (10 mg/kg), and the glucocorticoid betamethasone 17-valerate (3 mg/kg) inhibited the scratching. … Zileuton (100 mg/kg) inhibited the increased activity of the cutaneous nerve branch induced by an intradermal injection of the extract, suggesting the peripheral action. …
  • NAID 10024315632
  • Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis


Zileuton comes as a tablet and an extended-release (long-acting) tablet to take by mouth. The tablet is usually taken four times a day with or without food. The extended-release tablet is usually taken twice a day, within one hour after ...
旧い結節性紅斑に合致した.Zileutonを中止し,数カ月で皮膚病変は消褪した.約1年後,ロイコトリエン受容体拮抗剤であるモンテルカストを開始したところ,約3 カ月後 ...


 Zileuton (marketed as Zyflo and Zyflo CRZileuton Enantiomers Structural  zileuton marketed as zyflo and zyflo crzyflo generic name zileuton imprint 600 a File:Zileuton.png - Wikimedia CommonsZyflo (Zileutin) Drug Information