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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/08/01 16:46:27」(JST)

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  • Synthesis and Biological Evaluation of N-Aryl-5-Aryloxazol-2-Amine Derivatives as 5-Lipoxygenase Inhibitors.
  • Suh JH1, Yum EK, Cho YS.
  • Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).2015 Jun 3. [Epub ahead of print]
  • We describe the synthesis and biological evaluation of N-aryl-5-aryloxazol-2-amine derivatives that are able to inhibit 5-lipoxygenase (5-LOX), a key enzyme of leukotriene synthesis, for the treatment of inflammation-related diseases including asthma and rheumatoid arthritis. A novel structural moie
  • PMID 26040270
  • Genome-wide association study of leukotriene modifier response in asthma.
  • Dahlin A1, Litonjua A2, Irvin CG3, Peters SP4, Lima JJ5, Kubo M6, Tamari M6, Tantisira KG2.
  • The pharmacogenomics journal.Pharmacogenomics J.2015 Jun 2. doi: 10.1038/tpj.2015.34. [Epub ahead of print]
  • Heterogeneous therapeutic responses to leukotriene modifiers (LTMs) are likely due to variation in patient genetics. Although prior candidate gene studies implicated multiple pharmacogenetic loci, to date, no genome-wide association study (GWAS) of LTM response was reported. In this study, DNA and p
  • PMID 26031901
  • New insights into novel inhibitors against deoxyhypusine hydroxylase from plasmodium falciparum: compounds with an iron chelating potential.
  • von Koschitzky I1, Gerhardt H, Lämmerhofer M, Kohout M, Gehringer M, Laufer S, Pink M, Schmitz-Spanke S, Strube C, Kaiser A.
  • Amino acids.Amino Acids.2015 Jun;47(6):1155-66. doi: 10.1007/s00726-015-1943-z. Epub 2015 Feb 26.
  • Deoxyhypusine hydroxylase (DOHH) is a dinuclear iron enzyme required for hydroxylation of the aminobutyl side chain of deoxyhypusine in eukaryotic translation initiation factor 5A (eIF-5A), the second step in hypusine biosynthesis. DOHH has been recently identified in P. falciparum and P. vivax. Bot
  • PMID 25715757


  • Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice
  • Tsukumo Yukihito,Harada Daisuke,Manabe Haruhiko
  • Journal of pharmacological sciences 113(3), 255-262, 2010-07-20
  • … The severe scratching behavior was suppressed by the 5-lipoxygenase inhibitor zileuton and leukotriene B<SUB>4</SUB>–receptor antagonist ONO-4057, but not by the cysteinyl leukotriene–receptor antagonist montelukast. …
  • NAID 10029889358
  • Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice
  • Kuraishi Yasushi,Ohtsuka Eiji,Nakano Tasuku [他],KAWAI Sanae,ANDOH Tsugunobu,NOJIMA Hiroshi,KAMIMURA Kiyoshi
  • Journal of pharmacological sciences 105(1), 41-47, 2007-09-20
  • … The 5-lipoxygenase inhibitor zileuton (100 mg/kg), the 5-lipoxygenase activating peptide inhibitor MK-886 (10 mg/kg), and the glucocorticoid betamethasone 17-valerate (3 mg/kg) inhibited the scratching. … Zileuton (100 mg/kg) inhibited the increased activity of the cutaneous nerve branch induced by an intradermal injection of the extract, suggesting the peripheral action. …
  • NAID 10024315632
  • Overexpression of 5-lipoxygenase in rat and human esophageal adenocarcinoma and inhibitory effects of zileuton and celecoxib on carcinogenesis