出典: meddic



  • Cognition-impairing effects of benzodiazepine-type drugs: Role of GABA(A) receptor subtypes in an executive function task in rhesus monkeys.
  • Makaron L, Moran CA, Namjoshi O, Rallapalli S, Cook JM, Rowlett JK.SourceDivision of Neuroscience, New England Primate Research Center, Harvard Medical School, Box 9102, 1 Pine Hill Drive, Southborough, MA 01772, USA; Division of Veterinary Resources, New England Primate Research Center, Harvard Medical School, Box 9102, 1 Pine Hill Drive, Southborough, MA 01772, USA. Electronic address:
  • Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2013 Jan 2. pii: S0091-3057(12)00352-8. doi: 10.1016/j.pbb.2012.12.018. [Epub ahead of print]
  • The present studies evaluated the role of α1 and α5 subunit-containing GABA(A) receptors (α1GABA(A) and α5GABA(A) receptors, respectively) in the ability of benzodiazepine (BZ)-type drugs to alter performance in the cognitive domain of executive function. Five adult female rhesus monkeys (ages o
  • PMID 23290931
  • Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration.
  • Huedo-Medina TB, Kirsch I, Middlemass J, Klonizakis M, Siriwardena AN.SourceDepartment of Allied Health Sciences, University of Connecticut, 358 Mansfield Road U-2101, Storrs, CT 06269-2101, USA.
  • BMJ (Clinical research ed.).BMJ.2012 Dec 17;345:e8343. doi: 10.1136/bmj.e8343.
  • OBJECTIVES: To investigate the effectiveness of non-benzodiazepine hypnotics (Z drugs) and associated placebo responses in adults and to evaluate potential moderators of effectiveness in a dataset used to approve these drugs.DESIGN: Systematic review and meta-analysis.DATA SOURCE: US Food and Drug A
  • PMID 23248080
  • Pharmacokinetic evaluation of eszopiclone: clinical and therapeutic implications.
  • Greenblatt DJ, Zammit GK.SourceTufts University School of Medicine, Tufts Medical Center, Department of Molecular Physiology and Pharmacology, Sackler Program in Pharmacology and Experimental Therapeutics, 136 Harrison Avenue, Boston, MA 02111, USA.
  • Expert opinion on drug metabolism & toxicology.Expert Opin Drug Metab Toxicol.2012 Dec;8(12):1609-18. doi: 10.1517/17425255.2012.741588. Epub 2012 Nov 6.
  • INTRODUCTION: Eszopiclone is the active S-enantiomer of R,S-zopiclone, and is a cyclopyrrolone hypnotic acting via the GABA-benzodiazepine receptor system. Nearly 6 million prescriptions for eszopiclone are written yearly in the United States.AREAS COVERED: This paper addresses the pharmacokinetic p
  • PMID 23126273


  • Strain Difference of Oxidative Metabolism of the Sedative-hypnotic Zaleplon by Aldehyde Oxidase and Cytochrome P450 In Vivo and In Vitro in Rats
  • TANOUE Chiaki,SUGIHARA Kazumi,URAMARU Naoto,WATANABE Yoko,TAYAMA Yoshitaka,OHTA Shigeru,KITAMURA Shigeyuki
  • Drug Metabolism and Pharmacokinetics 28(3), 269-273, 2013
  • …   The in vivo and in vitro metabolism of the sedative-hypnotic agent zaleplon (ZAL) to 5-hydroxylated ZAL (5-oxo-ZAL) and N-desethylated ZAL (desethyl-ZAL) was studied in four strains of rats. …
  • NAID 130004463299
  • Synthetic studies connected with the preparation of N-〔3-(3-cyanopyrazolo〔1,5-a〕pyrimidin-5-yl)phenyl〕-N-ethylacetamide, a zaleplon regioisomer
  • Radl Stanislav,Blahovcova Michaela,Tkadlecova Marcela [他]
  • Heterocycles 80(2), 1359-1379, 2010-03-01
  • NAID 40016991499
  • Determination of 14 benzodiazepines and hydroxy metabolites, zaleplon and zolpidem as tert-butyldimethylsilyl derivatives compared with other common silylating reagents in whole blood by gas chromatography-mass spectrometry
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 818(2), 175-189, 2005-04-25
  • NAID 10016980532


Sonataソナタ(ザレプロンZaleplon)睡眠補助のSonataソナタ(ザレプロンZaleplon)睡眠補助などの個人輸入のサイトです。海外医薬品 アメリカの医師専用:PDR書に掲載された信頼の医薬品です。Sonataソナタ(ザレプロンZaleplon)睡眠 ...
Zaleplon may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: drowsiness dizziness lightheadedness lack of coordination numbness, burning, or tingling in the hands or feet







  • 非ベンゾジアゼピン系睡眠薬;超短期型;ω1ベンゾジアゼピン結合部位作用