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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/01/29 21:32:15」(JST)

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  • Pro-apoptotic effect of anti-β(1)-adrenergic receptor antibodies in periodontitis patients.
  • Reina S, Ganzinelli S, Sterin-Borda L, Borda E.SourcePharmacology Unit, School of Dentistry, University of Buenos Aires, Buenos Aires, Argentina; National Research Council of Argentina, Buenos Aires, Argentina.
  • International immunopharmacology.Int Immunopharmacol.2012 Oct 24. pii: S1567-5769(12)00303-7. doi: 10.1016/j.intimp.2012.10.011. [Epub ahead of print]
  • An anti-β(1)-adrenergic antibody from the sera of periodontitis patients (anti-β(1)-AR IgG) against the second extracellular loop of the human β(1)-adrenoceptor (β(1)-AR) has been shown to cause rat atria apoptosis. The anti-β(1)-AR IgG binds and activates atria β(1)-AR, increasing the intrace
  • PMID 23103827
  • Norepinephrine suppresses IFN-γ and TNF-α production by murine intestinal intraepithelial lymphocytes via the β₁ adrenoceptor.
  • Takayanagi Y, Osawa S, Ikuma M, Takagaki K, Zhang J, Hamaya Y, Yamada T, Sugimoto M, Furuta T, Miyajima H, Sugimoto K.SourceFirst Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
  • Journal of neuroimmunology.J Neuroimmunol.2012 Apr;245(1-2):66-74. Epub 2012 Mar 6.
  • We examined whether norepinephrine (NE) had direct effects on cytokine production by murine intestinal intraepithelial lymphocytes (IELs), compared with splenocytes. CD3⁺ IELs and CD3⁺ splenocytes expressed α(1B), α(1D), α(2C), β₁, β₂, and β₃ adrenoceptors (ARs). NE significantly sup
  • PMID 22398028


  • Characterization of β-Adrenoceptor Subtype in Bladder Smooth Muscle in Cynomolgus Monkey
  • Takeda Hiroo,Yamazaki Yoshinobu,Akahane Masuo [他],AKAHANE Satoshi,MIYATA Hiroshi,IGAWA Yasuhiko,NISHIZAWA Osamu
  • The Japanese journal of pharmacology 88(1), 108-113, 2002-01-01
  • xamoterol. …
  • NAID 10007944942
  • Cardiomyopathic Hamster Hearts : Long-Term Effects of Drugs on Catecholamine Contents and Binding Characteristics of α_1- and β_1-Adrenergic Receptors
  • 渡辺 賢一,柴田 昭,若林 広行,嶋田 健次,佐々木 佳子,長友 孝文
  • Biological & Pharmaceutical Bulletin 16(7), 660-663, 1993-07-15
  • … In addition, the effects of bunazosin, atenolol, xamoterol, ketanserin, and verapamil on the catecholamine content and [^3H]prazosin, [^3H]CGP12177 bindings to α_1- and β_1-adrenergic receptors of myocardium were compared with those of the controls. … (3) Xamoterol induced a higher K_d value for β_1-adrenoceptors and lower dopamine content than for those with cardiomyopathy. …
  • NAID 110003640317
  • Xamoterol in sinus node disease


Xamoterol is a cardiac stimulant. It works by binding to the β1 adrenergic receptor . It is a 3rd generation adrenergic beta receptor partial agonist. It provides cardiac stimulation at rest but it acts as a blocker during exercise.
1 Xamoterol (Corwin, Carwin, Corwil, Xamtol, ICI 118,587) is a β-adrenoceptor partial agonist which is of benefit in the chronic treatment of heart failure (e.g. The German and Austrian Xamoterol Study Group, 1988). These results contrast with ...