weight loss

出典: meddic

体重減少

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/04/19 07:02:09」(JST)

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英文文献

  • Fatty Acid synthase inhibitor c75 ameliorates experimental colitis.
  • Matsuo S1, Yang WL2, Aziz M2, Kameoka S3, Wang P2.Author information 1Department of Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, and The Feinstein Institute for Medical Research, Manhasset, New York, United States of America Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan.2Department of Surgery, Hofstra North Shore-Long Island Jewish School of Medicine, and The Feinstein Institute for Medical Research, Manhasset, New York, United States of America.3Department of Surgery II, Tokyo Women's Medical University, Tokyo, Japan.AbstractAbnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD). C75 is a synthetic α-methylene-γ-butyrolactone compound that inhibits FASN activity. We hypothesized that C75 treatment could effectively reduce the severity of experimental colitis. Male C57BL/6 mice were fed 4% dextran sodium sulfate (DSS) for 7 d. C75 (5 mg/kg body weight) or dimethyl sulfoxide (DMSO) (vehicle) was administered intraperitoneally from d 2 to 6. Clinical parameters were monitored daily. Mice were euthanized on d 8 for histological evaluation and measurements of colon length, chemokine, cytokine and inflammatory mediator expression. C75 significantly reduced body weight loss from 23% to 15% on d 8, compared with the vehicle group. The fecal bleeding, diarrhea and colon histological damage scores in the C75-treated group were significantly lower than scores in the vehicle animals. Colon shortening was significantly improved after C75 treatment. C75 protected colon tissues from DSS-induced apoptosis by inhibiting caspase-3 activity. Macrophage inflammatory protein 2, keratinocyte-derived chemokine, myeloperoxidase activity and proinflammatory cytokines (tumor necrosis factor-α, interleukin [IL]-1β and IL-6) in the colon were significantly downregulated in the C75-treated group, compared with the vehicle group. Treatment with C75 in colitis mice inhibited the elevation of FASN, cyclooxygenase-2 and inducible nitric oxide synthase expression as well as IκB degradation in colon tissues. C75 administration alleviates the severity of colon damage and inhibits the activation of inflammatory pathways in DSS-induced colitis. Thus, inhibition of FASN may represent an attractive therapeutic potential for treating IBD.
  • Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 24;20(1):1-9. doi: 10.2119/molmed.2013.00113.
  • Abnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel disease (IBD). C75 is a synthetic α-methylene-γ-butyrolactone compound that inhibits FASN activ
  • PMID 24306512
  • TNF-α Upregulates Sclerostin Expression in Obese Mice Fed a High-Fat Diet.
  • Baek K, Hwang HR, Park HJ, Kwon A, Qadir AS, Ko SH, Woo KM, Ryoo HM, Kim GS, Baek JH.Author information Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Korea; Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Gangneung-Wonju National University, Gangwondo, Korea.AbstractSclerostin decreases bone mass by antagonizing the Wnt signaling pathway. We examined whether obesity-induced bone loss is associated with the expression of sclerostin. Five-week-old male mice were assigned to one of two groups (n = 10 each) and fed either a control diet (10% kcal from fat; CON) or a high-fat diet (60% kcal from fat; HF) for 12 weeks. Thex final body weight and whole body fat mass of the HF mice were higher than those of the CON mice. The distal femur cancellous bone mineral density and bone formation rate was lower in HF mice than in CON mice. The percent erosion surface was higher in the HF mice than the CON mice. The serum levels and femoral osteocytic protein expression levels of tumor necrosis factor-α (TNF-α) were significantly higher in HF mice than in CON mice. Sclerostin mRNA levels and osteocytic sclerostin protein levels in femoral cortex were also higher in HF mice than in CON mice. Sclerostin expression in MLO-Y4 osteocytes increased with TNF-α treatment, and TNF-α-induced sclerostin expression was blocked by the inhibition of NF-κB activation. Chromatin immunoprecipitation and a luciferase reporter assay demonstrated that NF-κB directly binds to the NF-κB binding elements on the mouse sost promoter and stimulates sclerostin expression. These results support a model in which, in the context of obesity or other inflammatory diseases that increase the production of TNF-α, TNF-α upregulates the expression of sclerostin through NF-κB signaling pathway, thus contributing to bone loss. J. Cell. Physiol. 229: 640-650, 2014. © 2013 Wiley Periodicals, Inc.
  • Journal of cellular physiology.J Cell Physiol.2014 May;229(5):640-50. doi: 10.1002/jcp.24487.
  • Sclerostin decreases bone mass by antagonizing the Wnt signaling pathway. We examined whether obesity-induced bone loss is associated with the expression of sclerostin. Five-week-old male mice were assigned to one of two groups (n = 10 each) and fed either a control diet (10% kcal from fat; CON)
  • PMID 24446199
  • Metabolic abnormalities and hypoleptinemia in α-synuclein A53T mutant mice.
  • Rothman SM1, Griffioen KJ1, Fishbein KW2, Spencer RG2, Makrogiannis S3, Cong WN4, Martin B4, Mattson MP5.Author information 1Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.2Magnetic Resonance Imaging & Spectroscopy Section, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.3Longitudinal Studies Section, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.4Laboratory of Clinical Investigation National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.5Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD, USA. Electronic address: mark.mattson@nih.gov.AbstractParkinson's disease (PD) patients frequently display loss of body fat mass and increased energy expenditure, and several studies have outlined a relationship between these metabolic abnormalities and disease severity, yet energy metabolism is largely unstudied in mouse models of PD. Here we characterize metabolic and physiologic responses to a high calorie diet (HCD) in mice expressing in neurons a mutant form of human α-synuclein (A53T) that causes dominantly inherited familial forms of the disease. A53T (SNCA) and wild type (WT) littermate mice were placed on a HCD for 12 weeks and evaluated for weight gain, food intake, body fat, blood plasma leptin, hunger, glucose tolerance, and energy expenditure. Results were compared with both SNCA and WT mice on a control diet. Despite consuming similar amounts of food, WT mice gained up to 66% of their original body weight on a HCD, whereas SNCA mice gained only 17%. Further, after 12 weeks on a HCD, magnetic resonance imaging analysis revealed that WT mice had significantly greater total and visceral body fat compared with SNCA mice (p < 0.007). At the age of 24 weeks SNCA mice displayed significantly increased hunger compared with WT (p < 0.03). At the age of 36 weeks, SNCA mice displayed significant hypoleptinemia compared with WT, both on a normal diet and a HCD (p < 0.03). The HCD induced insulin insensitivity in WT, but not SNCA mice, as indicated by an oral glucose tolerance test. Finally, SNCA mice displayed greater energy expenditure compared with WT, as measured in a Comprehensive Laboratory Animal Monitoring System, after 12 weeks on a HCD. Thus, SNCA mice are resistant to HCD-induced obesity and insulin resistance and display reduced body fat, increased hunger, hypoleptinemia and increased energy expenditure. Our findings reveal a profile of metabolic dysfunction in a mouse model of PD that is similar to that of human PD patients, thus providing evidence that α-synuclein pathology is sufficient to drive such metabolic abnormalities and providing an animal model for discovery of the underlying mechanisms and potential therapeutic interventions.
  • Neurobiology of aging.Neurobiol Aging.2014 May;35(5):1153-61. doi: 10.1016/j.neurobiolaging.2013.10.088. Epub 2013 Oct 22.
  • Parkinson's disease (PD) patients frequently display loss of body fat mass and increased energy expenditure, and several studies have outlined a relationship between these metabolic abnormalities and disease severity, yet energy metabolism is largely unstudied in mouse models of PD. Here we characte
  • PMID 24239384

和文文献

  • 今月の症例 オルメサルタンによる体重減少,腎不全を伴う重症の水様性下痢を来たした1例
  • 小泉 忠史,古家 乾,馬場 英 [他]
  • 日本内科学会雑誌 104(6), 1167-1174, 2015-06-10
  • NAID 40020510730
  • NaCl溶液中における純アルミニウム1050とCFRPとのガルバニック腐食挙動 (第61回材料と環境討論会 速報論文特集)
  • 境 昌宏,坂本 千波
  • 材料と環境 = Corrosion engineering of Japan 64(6), 224-227, 2015-06
  • NAID 40020511307
  • Physical activity and lifestyle intervention
  • Nishiwaki Masato,Matsumoto Naoyuki
  • The journal of physical fitness and sports medicine : JPFSM : official journal of the Japanese Society of Physical Fitness and Sports Medicine 4(2), 187-195, 2015-05
  • NAID 40020479087

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★リンクテーブル★
リンク元体重減少」「るいそう」「lost weight」「loss of weight」「weight decrease
拡張検索neonatal weight loss」「simple weight loss amenorrhea」「amenorrhea due to weight loss」「weight loss amenorrhea
関連記事loss」「weight」「weigh」「weighted」「eighties

体重減少」

  [★]

weight loss, weight reduction
体重



るいそう」

  [★]

emaciation. wasting, weight loss
痩せやせ羸痩
萎縮



lost weight」

  [★]

loss of weightweight decreaseweight lossweight reduction


loss of weight」

  [★]

lost weightweight decreaseweight lossweight reduction


weight decrease」

  [★]

loss of weightlost weightweight lossweight reduction


neonatal weight loss」

  [★] 生理的体重減少、新生児体重減少


simple weight loss amenorrhea」

  [★] 単純体重減少性無月経


amenorrhea due to weight loss」

  [★] 体重減少性無月経


weight loss amenorrhea」

  [★] 体重減少性無月経


loss」

  [★]

  • n.
declinedecreasediminishdiminutiondown-regulatedown-regulationdownregulatedownregulationfallreducereduction


WordNet   license wordnet

「the amount by which the cost of a business exceeds its revenue; "the company operated at a loss last year"; "the company operated in the red last year"」
red ink, red

WordNet   license wordnet

「gradual decline in amount or activity; "weight loss"; "a serious loss of business"」

WordNet   license wordnet

「something that is lost; "the car was a total loss"; "loss of livestock left the rancher bankrupt"」

WordNet   license wordnet

「the disadvantage that results from losing something; "his loss of credibility led to his resignation"; "losing him is no great deprivation"」
deprivation

WordNet   license wordnet

「the act of losing someone or something; "everyone expected him to win so his loss was a shock"」

WordNet   license wordnet

「the experience of losing a loved one; "he sympathized on the loss of their grandfather"」

PrepTutorEJDIC   license prepejdic

「〈U〉(…を)『失うこと』,紛失《+『of』+『名』》 / 〈C〉(…の)『損害』,損失;損失額《+『of』+『名』》 / 〈U〉〈C〉(…に)『負けること』,(…の)敗北;失敗《+『of』+『名』》 / 〈U〉(状態・程度の)『減少』,低下 / 《複数形で》(戦場における)(人の)損害,此傷者数」


weight」

  [★]

  • n.

WordNet   license wordnet

「(statistics) a coefficient assigned to elements of a frequency distribution in order to represent their relative importance」
weighting

WordNet   license wordnet

「the relative importance granted to something; "his opinion carries great weight"; "the progression implied an increasing weightiness of the items listed"」
weightiness

WordNet   license wordnet

「an oppressive feeling of heavy force; "bowed down by the weight of responsibility"」

PrepTutorEJDIC   license prepejdic

「〈u〉『重さ』,重量,目方;体重;《a weight》(…の)重さ《+of+名》 / 〈u〉重さ(重力が物体に及ぼす力) / 〈u〉衡法(重量を示す体係) / 〈c〉重量単位 / 〈c〉(はかりの)おもり,分銅;(一般に)重いもの,おもし / 〈u〉重要性,価値 / 〈u〉《しばしば a weight》精神的な重荷,負担 / (…で)…‘に'重荷を負わせる;…‘を'圧迫する;苦しめる《+名+with+名》 / …‘を'重くする」

WordNet   license wordnet

「sports equipment used in calisthenic exercises and weightlifting; it is not attached to anything and is raised and lowered by use of the hands and arms」
free weight, exercising weight

WordNet   license wordnet

「an artifact that is heavy」

WordNet   license wordnet

「the vertical force exerted by a mass as a result of gravity」


weigh」

  [★]

  • v.
comparativecomparecomparisonweighing

WordNet   license wordnet

「have a certain weight」

PrepTutorEJDIC   license prepejdic

「…‘の'『重さを計る』 / 〈ある重さ〉‘を'『計量する』,計る / (…と比較して)…‘を'『検討する』,考慮する〈+名 against+名〉 / 『重さがある』,目方がかかる / (…にとって)『重要である』,(‥に)重要糸される〈+with+名〉」

WordNet   license wordnet

「determine the weight of; "The butcher weighed the chicken"」
librate

WordNet   license wordnet

「to be oppressive or burdensome; "weigh heavily on the mind", "Something pressed on his mind"」
press


weighted」

  [★]

  • adj.
  • 重みつきの、加重した
summation

WordNet   license wordnet

「adjusted to reflect value or proportion; "votes weighted according to the size of constituencies"; "a law weighted in favor of landlords"; "a weighted average"」

PrepTutorEJDIC   license prepejdic

「《補語にのみ用いて》(…に)有利な《+toward+名》」

eighties」

  [★]

WordNet   license wordnet

「the decade from 1880 to 1889」
1880s

WordNet   license wordnet

「the decade from 1980 to 1989」
1980s

WordNet   license wordnet

「the time of life between 80 and 90」
mid-eighties




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