ビトロネクチン受容体
- 関
- integrin alphaVbeta3
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/22 17:11:26」(JST)
[Wiki en表示]
αVβ3 is a type of integrin that is a receptor for vitronectin.[1] It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed by platelets. Furthermore it is a receptor for phagocytosis on macrophages or dendritic cells.[2]
Inhibitors like etaracizumab may be used as antiangiogenics.
See also
- Proteases in angiogenesis
References
- ^ Hermann P, Armant M, Brown E, Rubio M, Ishihara H, Ulrich D, Caspary RG, Lindberg FP, Armitage R, Maliszewski C, Delespesse G, Sarfati M (February 1999). "The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23". J. Cell Biol. 144 (4): 767–75. doi:10.1083/jcb.144.4.767. PMC 2132927. PMID 10037797.
- ^ Yamaguchi H, Takagi J, Miyamae T, Yokota S, Fujimoto T, Nakamura S, Ohshima S, Naka T, Nagata S (May 2008). "Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus". J. Leukoc. Biol. 83 (5): 1300–7. doi:10.1189/jlb.1107730. PMID 18303131.
External links
- integrin alphaVbeta3 at the US National Library of Medicine Medical Subject Headings (MeSH)
Integrins
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Alpha |
- A1
- A2
- A3
- A4
- A5
- A6
- A7
- A8
- A9
- A10
- A11
- AD
- AE
- AL
- AM
- AV
- AX
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Beta |
|
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Dimers |
Cytoadhesin receptor: |
- Integrin alpha6beta4
- Glycoprotein IIb/IIIa
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Fibrinogen receptor: |
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Fibronectin receptor: |
- Integrin alpha2beta1
- Integrin alpha4beta1
- Integrin alpha5beta1
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|
Leukocyte-adhesion receptor: |
- LFA-1
- Macrophage-1 antigen
- Integrin alphaXbeta2
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Very late antigen receptor: |
- Integrin alpha1beta1
- Integrin alpha2beta1
- Integrin alpha3beta1
- VLA-4
- Alpha-5 beta-1
- Integrin alpha6beta1
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Vitronectin receptor: |
- Alpha-v beta-3
- Alpha-v beta-5
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see also cell surface receptor deficiencies
Index of signal transduction
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Description |
- Intercellular
- neuropeptides
- growth factors
- cytokines
- hormones
- Cell surface receptors
- ligand-gated
- enzyme-linked
- G protein-coupled
- immunoglobulin superfamily
- integrins
- neuropeptide
- growth factor
- cytokine
- Intracellular
- adaptor proteins
- GTP-binding
- MAP kinase
- Calcium signaling
- Lipid signaling
- Pathways
- hedgehog
- Wnt
- TGF beta
- MAPK ERK
- notch
- JAK-STAT
- apoptosis
- hippo
- TLR
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Antiangiogenics
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Endogenous Regulation |
- Angiopoietin 2
- angiostatin
- canstatin
- calreticulin
- endostatin
- IFN-α
- IFN-β
- IFN-γ
- CXCL10
- IL-4
- IL-12
- IL-18
- maspin
- Meth-1
- Meth-2
- osteopontin
- platelet factor-4
- prolactin
- proliferin-related protein
- prothrombin (kringle domain-2)
- antithrombin III fragment
- SPARC
- Thrombospondin 1
- TIMP
- vasostatin
- VEGI
- soluble VEGFR-1
- NRP-1
- CDAI
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Exogenous Regulation |
- 2-Methoxyestradiol
- αVβ3 inhibitors
- angiostatic steroids
- heparin
- angiostatin
- bevacizumab
- carboxyamidotriazole
- Cartilage-Derived Angiogenesis Inhibitory Factor
- CM101
- endostatin
- IFN-α
- IL-12
- itraconazole
- linomide
- matrix metalloproteinase inhibitors
- platelet factor-4
- prolactin
- SU5416
- suramin
- tasquinimod
- tecogalan
- tetrathiomolybdate
- thalidomide
- thrombospondin
- thrombospondin
- TNP-470
- VEGFR antagonists
|
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See also |
- Angiogenesis
- Angiogenesis inhibitors
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UpToDate Contents
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English Journal
- Genetically modified T cells targeting neovasculature efficiently destroy tumor blood vessels, shrink established solid tumors and increase nanoparticle delivery.
- Fu X, Rivera A, Tao L, Zhang X.SourceDepartment of Biology and Biochemistry, Center for Nuclear Receptors and Cell Signaling, University of Houston, Houston, TX.
- International journal of cancer. Journal international du cancer.Int J Cancer.2013 Nov 15;133(10):2483-92. doi: 10.1002/ijc.28269. Epub 2013 Jul 11.
- Converting T cells into tumor cell killers by grafting them with a chimeric antigen receptor (CAR) has shown promise as a cancer immunotherapeutic. However, the inability of these cells to actively migrate and extravasate into tumor parenchyma has limited their effectiveness in vivo. Here we report
- PMID 23661285
- αv-Integrin isoform expression in primary human tumors and brain metastases.
- Vogetseder A, Thies S, Ingold B, Roth P, Weller M, Schraml P, Goodman SL, Moch H.SourceDepartment of Pathology, Institute for Surgical Pathology, University Hospital Zurich, Switzerland.
- International journal of cancer. Journal international du cancer.Int J Cancer.2013 Nov 15;133(10):2362-71. doi: 10.1002/ijc.28267. Epub 2013 Jun 10.
- To determine whether metastasis to brain is associated with altered expression patterns of integrins, we investigated the expression of αvβ3, αvβ5, αvβ6 and αvβ8 integrins in primary malignancies and metastases to brain of breast, lung and renal carcinomas and in malignant melanoma. Inhibito
- PMID 23661241
- Whole genome expression profiling and screening for differentially expressed cytokine genes in human bone marrow endothelial cells treated with humoral inhibitors in liver cirrhosis.
- Gao B, Sun W, Wang X, Jia X, Ma B, Chang Y, Zhang W, Xue D.SourceDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
- International journal of molecular medicine.Int J Mol Med.2013 Nov;32(5):1204-14. doi: 10.3892/ijmm.2013.1495. Epub 2013 Sep 13.
- Bone marrow endothelial cells (BMECs) are important components of the hematopoietic microenvironment in bone marrow, and they can secrete several types of cytokines to regulate the functions of hematopoietic stem/progenitor cells. To date, it is unknown whether BMECs undergo functional changes and l
- PMID 24043211
Japanese Journal
- PTA後の可溶性フィブリン (soluble fibrin, SF) の動態について : SFが上昇したPTA施行群の動脈硬化関連因子の検討
- 朝倉 伸司,佐々木 廉雄,足助 雄二,渡辺 弘規,加賀 誠,清水 ひろえ,川田 松江,播磨 晋太郎,長濱 裕,松田 道生
- 日本透析医学会雑誌 = Journal of Japanese Society for Dialysis Therapy 42(12), 947-953, 2009-12-28
- … 96-97)に存在するRGDドメインがフィブリンモノマーのE領域表面に露呈されること,また,これが細胞膜に存在し,フィブリノゲン受容体(fibrinogen receptor)として働くα5β1インテグリンおよびビトロネクチン受容体(vitronectin receptor)であるαvβ3をも巻き込みながら細胞伸展を促進することをわれわれはすでに報告しており,SFが単に血液凝固亢進を示す分子マーカーであるだけ …
- NAID 10026315970
- Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localized to alpha (v) beta3 integrin-containing membrane microdomains
Related Links
- The αvβ3 “vitronectin receptor” is a member of the integrin superfamily of adhesion molecules. As such, this 160/85 kDa heterodimeric protein exhibits man ... The αvβ3 integrin “vitronectin receptor” Michael A. Horton Department of ...
- 1. Int J Biochem Cell Biol. 1997 May;29(5):721-5. The alpha v beta 3 integrin "vitronectin receptor". Horton MA. The alpha v beta 3 "vitronectin receptor" is a member of the integrin superfamily of adhesion molecules. As such, this 160 ...
Related Pictures
★リンクテーブル★
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インテグリンαvβ3
- 関
- vitronectin receptor