WordNet

the 4th letter of the Roman alphabet (同)d
any of a group of organic substances essential in small quantities to normal metabolism
excitement and elation beyond the bounds of sobriety; "the intoxication of wealth and power"

PrepTutorEJDIC

deuteriumの化学記号
『ビタミン』,栄養素(身体の喜常な機能を維持するために少量ながら必要な有機化合物)
酔い,酩酊(めいてい) / 夢中,陶酔
(おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?

UpToDate Contents

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1. ビタミンDの概要 overview of vitamin d
2. 高リン血症の原因および治療の概要 overview of the causes and treatment of hyperphosphatemia
3. 高カルシウム血症の原因 etiology of hypercalcemia
4. 高カルシウム血症への診断的アプローチ diagnostic approach to hypercalcemia
5. 小児における急性中毒性代謝性脳症 acute toxic metabolic encephalopathy in children

English Journal

Vitamin D Intoxication Due to an Erroneously Manufactured Dietary Supplement in Seven Children.

Kara C, Gunindi F, Ustyol A, Aydin M.Author information Division of Pediatric Endocrinology, Department of Pediatrics, Ondokuz Mayis University, Samsun, Turkey.AbstractPediatric cases of vitamin D intoxication (VDI) with dietary supplements have not been previously reported. We report on 7 children with VDI caused by consumption of a fish oil supplement containing an excessively high dose of vitamin D due to a manufacturing error. Seven children aged between 0.7 and 4.2 years were admitted with symptoms of hypercalcemia. Initial median (range) serum concentrations of calcium and 25-hydroxyvitamin D were 16.5 (13.4-18.8) mg/dL and 620 (340-962) ng/mL, respectively. Repeated questioning of the parents revealed use of a fish oil that was produced recently by a local manufacturer. Analysis of the fish oil by gas chromatography/mass spectrometry revealed that the vitamin D3 content was ∼4000 times the labeled concentration. Estimated daily amounts of vitamin D3 intake varied between 266 000 and 800 000 IU. Patients were successfully treated with intravenous hydration, furosemide, and pamidronate infusions. With treatment, serum calcium returned to the normal range within 3 days (range: 2-7 days). Serum 25-hydroxyvitamin D levels normalized within 2 to 3 months. Complications, including nephrocalcinosis, were not observed throughout the 1-year follow-up. In conclusion, errors in manufacturing of dietary supplements may be a cause of VDI in children. Physicians should be aware of this possibility in unexplained VDI cases and repeatedly question the families about dietary supplement use. To prevent the occurrence of such unintentional incidents, manufacturers must always monitor the levels of ingredients of their products and should be rigorously overseen by governmental regulatory agencies, as is done in the pharmaceutical industry.
Pediatrics.Pediatrics.2013 Dec 2. [Epub ahead of print]
Pediatric cases of vitamin D intoxication (VDI) with dietary supplements have not been previously reported. We report on 7 children with VDI caused by consumption of a fish oil supplement containing an excessively high dose of vitamin D due to a manufacturing error. Seven children aged between 0.7 a
PMID 24298009

Hypercalcemia due to giant cell myocarditis: a case report.

Patel AM, Jessup M, Tomaszewski J, Doyle A.Author information Drexel University College of Medicine, Philadelphia, Pennsylvania.AbstractGranulomatous diseases are a rare cause of hypercalcemia. The pathogenesis is presumed to be from endogenous production of 1,25-dihydroxyvitamin D by activated macrophages in granulomatous lesions, which harbor the 1α-hydroxylase enzyme. Herein the first case of hypercalcemia associated with giant cell myocarditis, an unusual type of granulomatous process, is reported. In this case, a patient with giant cell myocarditis had development of progressive heart failure and cardiorenal syndrome that required biventricular support. One year later, hypercalcemia associated with a relatively high 1,25-vitamin D level and a concomitantly suppressed parathyroid hormone level developed in the presence of stage 4 chronic kidney disease. Her other workup of hypercalcemia was unrevealing for vitamin D intoxication and multiple myeloma. Computed tomography of her chest showed no signs of hilar lymphadenopathy. Her calcium levels returned to normal with low-dose steroid therapy and have remained normal following a successful heart transplant. This case illustrates an unusual cause of hypercalcemia thought to be due to extrarenal calcitriol production associated with giant cell myocarditis.
Progress in transplantation (Aliso Viejo, Calif.).Prog Transplant.2013 Dec;23(4):365-7. doi: 10.7182/pit2013106.
Granulomatous diseases are a rare cause of hypercalcemia. The pathogenesis is presumed to be from endogenous production of 1,25-dihydroxyvitamin D by activated macrophages in granulomatous lesions, which harbor the 1α-hydroxylase enzyme. Herein the first case of hypercalcemia associated with giant
PMID 24311400

Japanese Journal

非環式レチノイドによる肝発がん予防の臨床開発ならびに基礎的作用メカニズムについての研究

森脇久隆
ビタミン 86(12), 665-670, 2012-12-25
… Prognosis of liver cancer is poor due to a high recurrence rate, which is attributable to multicentric carcinogenesis in the liver under exposure to hepatitis virus infection or alcohol intoxication. …
NAID 110009562443

Notable Pink Excreta and Severe Myocardial Suppression in Superwarfarin (difethialone) Intoxication

Kamijo Yoshito,Sato Chie,Yoshimura Kuniko,Soma Kazui
Internal Medicine 50(22), 2819-2822, 2011
… Patients rarely consult physicians before developing coagulopathy or bleeding in most reported cases of superwarfarin intoxication. … Although she presented to the hospital in a comatose state, notable pink-colored excreta hinted at the consumption of anticoagulant rodenticide, which led to the early diagnosis of superwarfarin intoxication. … Supplementation of large doses of intravenous and oral vitamin K successfully prevented coagulopathy and bleeding. …
NAID 130001288672