vinblastine

出典: meddic

ビンブラスチン

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「periwinkle plant derivative used as an antineoplastic drug (trade name Velban) that disrupts cell division」
Velban

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/12/03 01:49:16」(JST)

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英文文献

  • Suppression of multidrug resistance by treatment with TRAIL in human ovarian and breast cancer cells with high level of c-Myc.
  • Kim DY, Kim MJ, Kim HB, Lee JW, Bae JH, Kim DW, Kang CD, Kim SH.SourceDepartment of Biochemistry, Pusan National University School of Medicine, Yangsan 626-870, South Korea.
  • Biochimica et biophysica acta.2011 Jul;1812(7):796-805. Epub 2011 Apr 15.
  • In this study, we investigated the role of c-Myc in overcoming multidrug resistance (MDR) in human ovarian and breast cancer cells by TRAIL. We showed that P-gp expressing MDR variants (Hey A8-MDR and MCF7-MDR cells) with high level of c-Myc were highly susceptible to TRAIL treatment when compared t
  • PMID 21514380
  • Safety assessment of intensive induction therapy in childhood anaplastic large cell lymphoma: report of the ALCL99 randomised trial.
  • Wrobel G, Mauguen A, Rosolen A, Reiter A, Williams D, Horibe K, Brugieres L, Le Deley MC; European Inter-Group for Childhood, Non-Hodgkin Lymphoma (EICNHL).SourceDepartment of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Medical University of Wroclaw, Wroclaw, Poland.
  • Pediatric blood & cancer.2011 Jul 1;56(7):1071-7. doi: 10.1002/pbc.22940. Epub 2011 Jan 28.
  • PMID 21280197

和文文献

  • 第59回日本泌尿器科学会中部総会シンポジウム「泌尿器科抗癌化学療法 : 最新レジメンの有効性と安全性」―司会の言葉―
  • 原 勲,元雄 良治
  • 泌尿器科紀要 57(3), 151-152, 2011-03-31
  • … (2) Urothelial cancer : gemcitabine and cisplatin (GC) therapy is taking over methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) therapy because of less toxicity. … However, regarding salvage chemotherapy, it is still controversial whether vinblastine, ifosphamide and platinum (VIP), paclitaxel, ifosphamide and platinum (TIP) and high dose chemotherapy should be selected. …
  • NAID 120003001362
  • ゲムシタビンとシスプラチンを含む併用化学療法を施行した転移性膀胱癌患者の生存に関するHuman equilibrative nucleoside transporter 1(hENT1) 発現の意義
  • 松村 永秀,原 勲
  • 泌尿器科紀要 57(3), 157-161, 2011-03-31
  • … Systemic combination chemotherapy, such as the methotrexate, vinblastine, doxorubicin and cisplatin (MVAC) regimen, has shown certain activity in advanced bladder cancer, but is associated with a significant toxicity burden, with a treatment-related mortality of about 4%. …
  • NAID 120003001360

関連リンク

Microtubule-disruptive drugs like vinblastine, colcemid, nocodazole have been reported to act by two mechanisms. [4] At very low concentrations they suppress microtubule dynamics and at higher concentrations they reduce ...
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision ...

関連画像

Vincaleucoblastin (vinblastine)Vinblastine: sejenis ubat kemoterapi yang vinblastine intravenous : Uses, Side Vinblastine-skeletal.svgFile:Structure of Vinblastine .FIGURE 1. The vinblastine-binding site.


★リンクテーブル★
リンク元ビンクリスチン」「M-VAC療法」「ビンブラスチン」「ビンカアルカロイド」「velban
拡張検索vinblastine sulfate

ビンクリスチン」

  [★]

vincristine, VCR
硫酸リューロクリスチン leurocristine sulfate
硫酸ビンクリスチン vincristine sulfate 
ONCO-TCSONCOVINVINCASAR PFSオンコビン oncovin


  • first aid step1 2006 p.84,310

特徴

構造

作用機序

  • M-phase-specific alkaloids that bind to tubulin and block polymerization of microtubules so that mitotic spindle cannot form (first aid step1 2006 p.310)

適応

  • part of the MOPP (Oncovin [vincristine]) regimen for lymphoma, Wilms' tumor, choriocarcinoma(first aid step1 2006 p.310)
  • MAPP regimen for Hodgkin disease, ALL lymphoma, CNS tumer, sarcoma, Wilms tumor

効能又は効果

副作用



M-VAC療法」

  [★]

M-VAC regimen
[[]]
[show details]

適応

ビンブラスチン」

  [★]

vinblastine, VLB
vinblastinum
硫酸ビンカロイコブラスチン vincaleukoblastine sulfate, VLB
硫酸ビンブラスチン vinblastine sulfate
エクザールAlkaban-AQ, Velban



ビンカアルカロイド」

  [★]

vinca alkaloid


velban」

  [★]

vinblastine sulfate
vinblastine


vinblastine sulfate」

  [★] ビンブラスチン硫酸ビンブラスチン




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