WordNet

the membrane that forms the wall of the blastocyst in early development; aids implantation in the uterine wall; "after implantation of the blastocyst in the uterine wall the trophoblast divides into two layers, the chorion and the placenta"

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1. 胎盤の発達および生理学 placental development and physiology
2. 母体 - 胎児接点の免疫 immunology of the maternal fetal interface
3. 胎盤病理組織報告 the placental pathology report
4. 妊娠性絨毛腫瘍：疫学、臨床的特徴、診断、病期分類、およびリスク層別化 gestational trophoblastic neoplasia epidemiology clinical features diagnosis staging and risk stratification
5. 妊娠性絨毛性疾患：病理 gestational trophoblastic disease pathology

Oxidative stress-induced Gadd45α inhibits trophoblast invasion and increases sFlt1/sEng secretions via p38 MAPK involving in the pathology of pre-eclampsia.

Liu X1, Deng Q1, Luo X1, Chen Y1, Shan N1, Qi H1.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2016 Dec;29(23):3776-85. doi: 10.3109/14767058.2016.1144744. Epub 2016 Mar 3.
BACKGROUND: Pre-eclampsia (PE) is one of the most common pregnancy-related complications. We have previously reported that growth arrest and DNA damage-inducible 45 alpha (Gadd45α) is over-expressed in trophoblasts in pre-eclamptic placentas, with an excessive activation of p38 mitogen-activated pr
PMID 26809169

Wnt5a inhibited human trophoblast cell line HTR8/SVneo invasion: implications for early placentation and preeclampsia.

Chen Y1,2, Zhang Y3, Deng Q1,2, Shan N1,2, Peng W1,2, Luo X1,2, Zhang H1,2, Baker PN2,4, Tong C1,2, Qi H1,2.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.J Matern Fetal Neonatal Med.2016 Nov;29(21):3532-8. doi: 10.3109/14767058.2016.1138102. Epub 2016 Feb 10.
OBJECTIVE: Wnt5a and Wnt signaling play potential roles in human placental and fetal development. The objective of this study is to explore the role of Wnt5a in the invasion of the human trophoblast cell line HTR8/SVneo and the probable mechanism of early placentation and preeclampsia in which Wnt5a
PMID 26865089

Histological comparison of partial hydatidiform mole and trisomy gestation specimens.

Wilson Y1, Bharat C2, Crook ML3, Kee AR3, Peverall J4, Ruba S3, Stewart CJ5.
Pathology.Pathology.2016 Oct;48(6):550-4. doi: 10.1016/j.pathol.2016.06.006. Epub 2016 Aug 26.
The distinction between partial hydatidiform mole (PHM) and trisomy gestation is not always straightforward histologically and it is unclear which morphological features, alone or in combination, provide the greatest diagnostic accuracy. We performed a comparative review of 89 products of conception
PMID 27575970

1) ヒト初期絨毛遺伝子の変化に着目した妊娠高血圧症候群発症の予知と予防(シンポジウム2:周産期「妊娠高血圧症候群の基礎と臨床-予防・治療の新戦略に向けて」,第65回日本産科婦人科学会・学術講演会)

小出馨子
日本産科婦人科學會雜誌 65(11), 2574-2582, 2013-11-01
… During the pathogenesis of preeclampsia (PE), inadequate trophoblast invasion of the maternal spiral arteries during early gestation due to immunological, genetic and environmental factors causes an insufficiency of maternal blood inflow into the intervillous space, leading to placental ischemia, as well as trophoblast hypoxia. …
NAID 110009674981

1) ヒト初期絨毛遺伝子の変化に着目した妊娠高血圧症候群発症の予知と予防(シンポジウム2:周産期「妊娠高血圧症候群の基礎と臨床-予防・治療の新戦略に向けて」,第65回日本産科婦人科学会・学術講演会)

小出馨子
日本産科婦人科學會雜誌 65(11), 2574-2582, 2013-11-01
… During the pathogenesis of preeclampsia (PE), inadequate trophoblast invasion of the maternal spiral arteries during early gestation due to immunological, genetic and environmental factors causes an insufficiency of maternal blood inflow into the intervillous space, leading to placental ischemia, as well as trophoblast hypoxia. …
NAID 110009661869

中島彰俊
日本産科婦人科學會雜誌 63(12), 2185-2197, 2011-12-01
… For example, villous trophoblasts do not express classical major histocompatibility complex (MHC) class I and class II molecules in humans, and human extravillous trophoblasts express only MHC-class I molecules such as human histocompatibility leukocyte antigen (HLA)-C, HLA-E, and HLA-G, which are specific ligands for uterine natural killer (NK) cells. … Additionally, decidual NK cells produce a number of cytokines that promote trophoblast proliferation and differentiation, as well as angiogenesis factors. …
NAID 110008799037