vesicle

出典: meddic

  • n.



WordNet   license wordnet

「a small anatomically normal sac or bladderlike structure (especially one containing fluid)」
cyst

PrepTutorEJDIC   license prepejdic

「小嚢,小胞,小水(気)胞,小空胞」

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英文文献

  • Vesicular powder as carrier for doxycycline hydrochloride and metronidazole combination therapy.
  • Gad HA1, Kamel AO, Sammour OA, El Dessouky HF.Author information 1Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Ain Shams University , Cairo , Egypt .AbstractIn this study, vesicular proniosomal powder encapsulating doxycycline hydrochloride (DH) and metronidazole (MT) combination therapy was developed using different types of spans, cholesterol (CH) and maltodextrin as a carrier. Proniosomal powder was free flowing and spherical in shape. The surfactant structure affected the entrapment efficiency of both drugs with highest value of Sp 60 proniosomes of 45.16% and 42.64% for DH and MT, respectively. Incorporation of CH influenced vesicle stability and permeability with optimum concentration of 10 mole%. Increasing the surfactant loading from 1 mM to 3 mM resulted in a significant decrease in the amount of drugs (mg) entrapped per mM lipid (from 9.95 to 1.13 and from 8.88 to 1.22 for DH and MT, respectively). Longer chain length surfactants produced larger vesicles. Surfactant hydrophilicity affected zeta potential. Both drugs were molecularly dispersed in the proniosomal powder with no chemical interaction with other components. Proniosomal powder was stable at 2-8 °C for three months.
  • Pharmaceutical development and technology.Pharm Dev Technol.2014 Sep;19(6):755-68. doi: 10.3109/10837450.2013.829098. Epub 2013 Aug 28.
  • In this study, vesicular proniosomal powder encapsulating doxycycline hydrochloride (DH) and metronidazole (MT) combination therapy was developed using different types of spans, cholesterol (CH) and maltodextrin as a carrier. Proniosomal powder was free flowing and spherical in shape. The surfactant
  • PMID 23981239
  • Delivery of green tea catechin and epigallocatechin gallate in liposomes incorporated into low-fat hard cheese.
  • Rashidinejad A1, Birch EJ2, Sun-Waterhouse D3, Everett DW4.Author information 1Department of Food Science, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Riddet Institute, Private Bag 11 222, Palmerston North 4442, New Zealand. Electronic address: ali.rashidinejad@otago.ac.nz.2Department of Food Science, University of Otago, PO Box 56, Dunedin 9054, New Zealand.3Plant and Food Research, Auckland Mail Centre, Private Bag 92169, Auckland 1142, New Zealand.4Department of Food Science, University of Otago, PO Box 56, Dunedin 9054, New Zealand; Riddet Institute, Private Bag 11 222, Palmerston North 4442, New Zealand.AbstractThe encapsulation of green tea catechin and epigallocatechin gallate (EGCG) in soy lecithin liposomes was examined at four concentrations (0%, 0.125%, 0.25% and 0.5% w/v), and inclusion in cheese at 0% and 0.25% w/v. The empty capsules had a mean diameter of 133nm and significantly (p<0.05) increased with the addition of catechin or EGCG. Electron microscopy revealed the lamellae and central core of the liposomes. Addition of antioxidants gave a significant (p<0.05) increase in the size of liposomes. Liposomes had surface potentials of -42.4 to -46.1mV with no significant difference between treatments, suggesting stable liposome systems. High efficiency (>70%) and yield (∼80%) were achieved from the incorporation of catechin or EGCG inside the liposome structure. Addition of either antioxidant increased the liposome phase transition temperature (>50°C). Nanocapsules containing these antioxidants were effectively retained within a low-fat hard cheese, presenting a simple and effective delivery vesicle for antioxidants.
  • Food chemistry.Food Chem.2014 Aug 1;156:176-83. doi: 10.1016/j.foodchem.2014.01.115. Epub 2014 Feb 6.
  • The encapsulation of green tea catechin and epigallocatechin gallate (EGCG) in soy lecithin liposomes was examined at four concentrations (0%, 0.125%, 0.25% and 0.5% w/v), and inclusion in cheese at 0% and 0.25% w/v. The empty capsules had a mean diameter of 133nm and significantly (p<0.05) incre
  • PMID 24629955
  • Analysis of 52 Rab GTPases from channel catfish and their involvement in immune responses after bacterial infections.
  • Wang R1, Zhang Y1, Liu S1, Li C1, Sun L1, Bao L1, Feng J1, Liu Z2.Author information 1The Fish Molecular Genetics and Biotechnology Laboratory, Aquatic Genomics Unit, School of Fisheries, Aquaculture and Aquatic Sciences, and Program of Cell and Molecular Biosciences, Auburn University, 203 Swingle Hall, Auburn, AL 36849, USA.2The Fish Molecular Genetics and Biotechnology Laboratory, Aquatic Genomics Unit, School of Fisheries, Aquaculture and Aquatic Sciences, and Program of Cell and Molecular Biosciences, Auburn University, 203 Swingle Hall, Auburn, AL 36849, USA. Electronic address: liuzhan@auburn.edu.AbstractRab genes, encoding a large family of monomeric G-proteins, contain over 60 members in the human genome. They have been recognized as crucial regulators for membrane trafficking including cargo sorting, vesicle formation, budding, motility, docking, fusion, secretory and endocytic pathway of host immune responses. However, little is known of the Rab gene family in teleost fish species. The development of full-length transcripts and whole genome sequences allow the identification and annotation of Rab GTPase gene family in catfish. In this study, a total of 52 Rab genes were identified from catfish cDNA and genome databases. Phylogenetic analysis assigned them into eleven subfamilies. Most Rab GTPases are conserved among vertebrates, though some of which are absent in fish genomes. Analysis of multiple RNA-seq datasets, along with real time PCR analysis revealed up-regulation of 10 Rab genes after bacterial infection. These included Rab3a, Rab4a, Rab4b, Rab5a, Rab5c, Rab7a, Rab9a, Rab11a, Rab11b, and Rab33a. Their up-regulation are temporally and spatially regulated in various tissues, but mostly induced at early stages after infection and in the gill and liver tissues, with the exception of Rab5c that is mostly up-regulated in the head kidney and trunk kidney. The complex pattern of their induced expression suggested both specific and cooperative actions of a these Rab genes in the acute immune responses to bacterial infection.
  • Developmental and comparative immunology.Dev Comp Immunol.2014 Jul;45(1):21-34. doi: 10.1016/j.dci.2014.01.026. Epub 2014 Feb 7.
  • Rab genes, encoding a large family of monomeric G-proteins, contain over 60 members in the human genome. They have been recognized as crucial regulators for membrane trafficking including cargo sorting, vesicle formation, budding, motility, docking, fusion, secretory and endocytic pathway of host im
  • PMID 24513270

和文文献

関連リンク

In cell biology, a vesicle is a small bubble within a cell, and thus a type of organelle. Enclosed by lipid bilayer, vesicles can form naturally, for example, during endocytosis (protein absorption). Alternatively, they may be prepared artificially, ...

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★リンクテーブル★
先読み小嚢
リンク元100Cases 39」「vesicular」「小水疱」「ベシクル」「ベジクル
拡張検索COP-coated vesicle」「large dense-core vesicle

小嚢」

  [★]

saccule
球形嚢


100Cases 39」

  [★]

erratic adj. adj. 軌道の定まらない。一貫性のない、不安定な、不規則
bowel motion 腸運動排便
fit adj. adj. 体調がよい、健康
emaciated adj.
glisten vi. ぴかぴか光る
dislodge
palliative
erythema multiforme 多形紅斑
dermatitis herpetiformis 疱疹状皮膚炎
itch 痒み
itching
celiac disease セリアック病
herpes gestationis 妊娠性疱疹
皮膚水疱
83歳 男性
主訴皮膚と口内における多数の水疱
現病歴水疱は2日前より出現水疱は破れやすく、赤色有痛性病変が残る。3ヶ月前から5kg体重が減少しており、食欲減退している。患者は体調の不調自覚してた。排便習慣が不規則になり、排便にいくらか血液を認めた。
既往歴:生来、健康であり、既往なし。
生活歴:一人住まい
嗜好歴:喫煙・飲酒無し
服薬歴:処方薬なし。マルチビタミンタブレットは体調の不調を感じてから薬局購入している。これ以外て薬を購入していない。
身体所見 examination
全身emaciateで調子悪そうである
皮膚全身皮膚水疱
口内:びらん(sore)あり sore有痛性びらん潰瘍
脈拍:102/minirregularly irregular → 不規則不整脈 → ( )
血圧:160/78 mmHg
上記以外心臓呼吸器系に異常を認めない。
腹部触診:6cmの硬い結節を肝の辺縁に触知。可動性のある硬性腫瘤を左腸骨窩に触知。
直腸診:鮮血色の血液糞便混合物が認められる
検査 examination
低値Hb, MCV,Alb
高値AlP
Q1. まず皮膚病変の診断をつけろ。
Q2. 次に皮膚病変と患者病態関連づけてみろ。
A. 尋常性天疱瘡
特徴:表皮内水疱、弛緩性水疱、ニコルスキー現象、口内びらん
病因癌腫リンパ腫、胸腺腫全身性エリテマトーデス特定薬物(ペニシラミンカプトプリル)などによる
治療ステロイド免疫抑制薬
鑑別疾患
水疱性類天疱瘡緊満性水疱水疱尋常性天疱瘡に比べて破れにくく大型になりやすい。
多形性紅斑中心水疱を伴った的形病変(target-shaped lesion with central blisters)。よく全身紅皮症と粘膜潰瘍と伴う(スティーブン・ジョンソン症候群)。病因単純ヘルペスウイルス薬剤(スルフォナミド)、悪性腫瘍
疱疹状皮膚炎:肘、膝、顔面小水疱病変(vesicular lesion)が形成される。vesicleblister(<0.5cm)より小さく、ひっかくことで破裂する。非常にかゆい。セリアック病合併することがある
・その他の疾患
 ・糖尿病
 ・妊娠性疱疹
 ・家族性水疱疾患
まとめ
悪性腫瘍合併しうる(→腫瘍存在下皮膚病変が出現したのであれば腫瘍随伴性天疱瘡診断されるべき)、
天疱瘡は気づかないうちに体液喪失し、あるいは水疱からの感染結果としての敗血症生命を脅かす。


vesicular」

  [★]

  • adj.
  • 小胞の
vesicle

WordNet   license wordnet

「of or relating to or involving vesicles; "normal vesicular breathing"」

PrepTutorEJDIC   license prepejdic

「小嚢の小胞の,小嚢(小胞)状の」

小水疱」

  [★]

vesicle
水疱弛緩性水疱緊満性水疱
  • 直径5mm以下



ベシクル」

  [★]

vesicle
小胞ベジクル小水疱


ベジクル」

  [★]

vesicle
小胞ベシクル小水疱

COP-coated vesicle」

  [★]

coatomer-coated vesicleCOPI-coated vesicleCOPII-coated vesicle


large dense-core vesicle」

  [★]

dense core vesicle


"http://meddic.jp/vesicle" より作成


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