veratridine

出典: meddic

ベラトリジン

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/06 14:16:57」(JST)

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英文文献

  • Lacosamide inhibits calcitonin gene-related peptide production and release at trigeminal level in the rat.
  • Greco MC1, Capuano A2, Navarra P1, Tringali G1.
  • European journal of pain (London, England).Eur J Pain.2016 Jul;20(6):959-66. doi: 10.1002/ejp.820. Epub 2016 Jan 5.
  • BACKGROUND: Several classes of drugs are effective in prevention and treatment of migraine, although they may differ among each other in their mode of action and in indications. One such class is represented by antiepileptics. Lacosamide is an approved antiepileptic drug that also shows antinocicept
  • PMID 26729049
  • Gramine derivatives targeting Ca2+ channels and Ser/Thr phosphatases: a new dual strategy for the treatment of neurodenerative diseases.
  • Lajarín-Cuesta R, Nanclares C, Arranz-Tagarro JA, González-Lafuente L, Arribas RL, Brito MA, Gandia L, de Los Ríos C.
  • Journal of medicinal chemistry.J Med Chem.2016 Jun 9. [Epub ahead of print]
  • We describe the synthesis of gramine derivatives and their pharmacological evaluation as multipotent drugs for the treatment of Alzheimer´s disease. An innovative multitarget approach is presented, targeting both voltage-gated Ca2+ channels, classically studied for neurodegenerative diseases, and S
  • PMID 27280380
  • Insecticide sensitivity of native chloride and sodium channels in a mosquito cell line.
  • Jenson LJ1, Anderson TD2, Bloomquist JR3.
  • Pesticide biochemistry and physiology.Pestic Biochem Physiol.2016 Jun;130:59-64. doi: 10.1016/j.pestbp.2015.11.012. Epub 2015 Nov 28.
  • The aim of this study was to investigate the utility of cultured Anopheles gambiae Sua1B cells for insecticide screening applications without genetic engineering or other treatments. Sua1B cells were exposed to the known insecticidal compounds lindane and DIDS, which inhibited cell growth at micromo
  • PMID 27155485

和文文献

  • Depolarizing stimuli cause persistent and selective loss of orexin in rat hypothalamic slice culture
  • Investigating the in vitro metabolism of veratridine : Characterization of metabolites and involved cytochrome P450 isoforms
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 877(3), 141-148, 2009-01-15
  • NAID 10028011771
  • Inhibition by Selenium Compounds of Catecholamine Secretion Due to Inhibition of Ca^<2+> Influx in Cultured Bovine Adrenal Chromaffin Cells
  • Journal of pharmacological sciences 101(3), 223-229, 2006-07-20
  • NAID 10018236954

関連リンク

Sigma-Aldrich offers Sigma-V5754, Veratridine for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... Packaging 10, 25, 100 mg in glass bottle Biochem/physiol Actions ...
View and buy high purity Veratridine from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents ... Biological Activity Voltage-gated Na + channel opener; increases intracellular Ca 2+ with no ...

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★リンクテーブル★
リンク元神経筋接合部」「ベラトリジン

神経筋接合部」

  [★]

neuromuscular junction (K)
神経筋シナプス neuromuscular synapse


神経筋接合部に作用する薬物 (GPC.225)

 
神経活動電位発生   tetrodotoxin
batrachotoxin
アセチルコリン放出 excess of Ca2+ hemicholinium
botulinus toxin
procaine
Mg2+
4-aminopyridine
lack of Ca2+
終板電位発生 succinylcholine(suxamethonium) curare alkaloids
decamethonium α-toxins
アセチルコリン加水分解 cholinesterase inhibitors  
筋活動電位発生 veratridine quinine
tetrodotoxin
筋収縮   procaine
dantrolene



ベラトリジン」

  [★]

veratridine
  • Na+チャネル開口




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