vasodilation

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「dilation of blood vessels (especially the arteries)」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/08/30 21:51:58」(JST)

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英文文献

  • Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats.
  • Ou M, Dang Y, Mazzuca MQ, Basile R, Khalil RA.Author information Vascular Surgery Research Laboratory, Division of Vascular and Endovascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.AbstractNormal pregnancy is associated with systemic vasodilation and decreased vascular contraction, partly due to increased release of endothelium-derived vasodilator substances. Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor acting via endothelin receptor type A (ETA R) and possibly type B (ETB R) in vascular smooth muscle cells (VSMCs), with additional vasodilator effects via endothelial ETB R. However, the role of ET-1 receptor subtypes in the regulation of vascular function during pregnancy is unclear. We investigated whether the decreased vascular contraction during pregnancy reflects changes in the expression/activity of ETAR and ETBR. Contraction was measured in single aortic VSMCs isolated from virgin, mid-pregnant (mid-Preg, day 12), and late-Preg (day 19) Sprague-Dawley rats, and the mRNA expression, protein amount, tissue and cellular distribution of ETAR and ETBR were examined using RT-PCR, Western blots, immunohistochemistry, and immunofluorescence. Phenylephrine (Phe, 10(-5)  M), KCl (51 mM), and ET-1 (10(-6)  M) caused VSMC contraction that was in late-Preg < mid-Preg and virgin rats. In VSMCs treated with ETB R antagonist BQ788, ET-1 caused significant contraction that was still in late-Preg < mid-Preg and virgin rats. In VSMCs treated with the ETAR antagonist BQ123, ET-1 caused a small contraction; and the ETBR agonists IRL-1620 and sarafotoxin 6c (S6c) caused similar contraction that was in late-Preg < mid-Preg and virgin rats. RT-PCR revealed similar ETAR, but greater ETBR mRNA expression in pregnant versus virgin rats. Western blots revealed similar ETAR, and greater protein amount of ETBR in endothelium-intact vessels, but reduced ETBR in endothelium-denuded vessels of pregnant versus virgin rats. Immunohistochemistry revealed prominent ETBR staining in the intima, but reduced ETAR and ETBR in the aortic media of pregnant rats. Immunofluorescence signal for ETAR and ETBR was less in VSMCs of pregnant versus virgin rats. The pregnancy-associated decrease in ETAR- and ETBR-mediated VSMC contraction appears to involve downregulation of ETAR and ETBR expression/activity in VSM, and may play a role in the adaptive vasodilation during pregnancy.
  • Journal of cellular physiology.J Cell Physiol.2014 Apr;229(4):489-501. doi: 10.1002/jcp.24469.
  • Normal pregnancy is associated with systemic vasodilation and decreased vascular contraction, partly due to increased release of endothelium-derived vasodilator substances. Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor acting via endothelin receptor type A (ETA R) and possibly type B
  • PMID 24105843
  • Gene-education interactions identify novel blood pressure Loci in the framingham heart study.
  • Basson J, Sung YJ, Schwander K, Kume R, Simino J, de Las Fuentes L, Rao D.Author information Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.AbstractBACKGROUND: Blood pressure (BP) variability has a genetic component, most of which has yet to be attributed to specific variants. One promising strategy for gene discovery is analysis of interactions between single-nucleotide polymorphisms (SNPs) and BP-related factors, including age, sex, and body mass index (BMI). Educational attainment, a marker for socioeconomic status, has effects on both BP and BMI.
  • American journal of hypertension.Am J Hypertens.2014 Mar;27(3):431-44. doi: 10.1093/ajh/hpt283. Epub 2014 Jan 28.
  • BACKGROUND: Blood pressure (BP) variability has a genetic component, most of which has yet to be attributed to specific variants. One promising strategy for gene discovery is analysis of interactions between single-nucleotide polymorphisms (SNPs) and BP-related factors, including age, sex, and body
  • PMID 24473254
  • Acute effects of a mixed meal on arterial stiffness and central hemodynamics in healthy adults.
  • Taylor JL, Curry TB, Matzek LJ, Joyner MJ, Casey DP.Author information Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota.AbstractBACKGROUND: Elevated central pressures and arterial stiffness are associated with increased peripheral resistance and higher sympathetic nervous system activity. Additionally, consumption of a meal is known to be sympathoexcitatory. However, the acute effects of a meal on aortic wave reflection and stiffness are unknown. Therefore, we tested the hypothesis that aortic wave reflection and stiffness would increase after a meal.
  • American journal of hypertension.Am J Hypertens.2014 Mar;27(3):331-7. doi: 10.1093/ajh/hpt211. Epub 2013 Nov 16.
  • BACKGROUND: Elevated central pressures and arterial stiffness are associated with increased peripheral resistance and higher sympathetic nervous system activity. Additionally, consumption of a meal is known to be sympathoexcitatory. However, the acute effects of a meal on aortic wave reflection and
  • PMID 24242825

和文文献

  • Poor Oral Health, That Is, Decreased Frequency of Tooth Brushing, Is Associated With Endothelial Dysfunction
  • Kajikawa Masato,Nakashima Ayumu,Maruhashi Tatsuya [他]
  • Circulation journal : official journal of the Japanese Circulation Society 78(4), 950-954, 2014-04
  • NAID 40020023742
  • 茶カテキンの経口投与によるヒト血管内皮機能の改善効果に関する研究
  • 田川 辰也,山上 樹里,柳瀬 織枝 [他]
  • 西南女学院大学紀要 18, 123-128, 2014
  • NAID 40020022986
  • Poor Oral Health, That Is, Decreased Frequency of Tooth Brushing, Is Associated With Endothelial Dysfunction
  • Kajikawa Masato,Nakashima Ayumu,Maruhashi Tatsuya,Iwamoto Yumiko,Iwamoto Akimichi,Matsumoto Takeshi,Hidaka Takayuki,Kihara Yasuki,Chayama Kazuaki,Goto Chikara,Taguchi Akira,Noma Kensuke,Higashi Yukihito
  • Circulation Journal, 2014
  • … Methods and Results: A total of 190 subjects who underwent health examinations (mean age, 57±18 years), including patients with cardiovascular disease, completed a questionnaire on oral health and frequency of tooth brushing, and underwent measurement of vascular function, flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation. … There was no significant difference in nitroglycerine-induced vasodilation between the 2 groups. …
  • NAID 130003391043

関連リンク

From Wikipedia, the free encyclopedia. Jump to: navigation, search. Vasodilation refers to the widening of blood vessels resulting from relaxation of smooth muscle cells within the vessel walls, particularly in the large arteries, smaller arterioles ...

関連画像

VasodilationvasodilationAlpha-BlockersBlood_Vessel_Vasodilation_Project_BV2.jpgVasodilation BuzzFile:Vasoconstriction and Vasodilation.png


★リンクテーブル★
リンク元angiectatic」「vasodilate」「hemangiectasis」「血管拡張作用」「血管拡張
拡張検索endothelium-dependent vasodilation

angiectatic」

  [★]

  • 血管拡張性の、血管拡張の
hemangiectasisvasodilatationvasodilatevasodilatingvasodilationvasodilativevasodilatory


vasodilate」

  [★]

  • 血管拡張する
angiectatichemangiectasisvasodilatationvasodilation


hemangiectasis」

  [★]

angiectaticvasodilatationvasodilatevasodilation

血管拡張作用」

  [★]

vasodilationvasodilatation
血管拡張血管拡張術


血管拡張」

  [★]

vasodilation, telangiectasis
発疹血管拡張薬




endothelium-dependent vasodilation」

  [★]




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