vaso-occlusive crisis

血管閉塞性発作

WordNet

1. an unstable situation of extreme danger or difficulty; "they went bankrupt during the economic crisis"
2. a crucial stage or turning point in the course of something; "after the crisis the patient either dies or gets better"
3. tending to occlude

PrepTutorEJDIC

1. (社会上・政治上の)『重大な事態』,『難局』,危機 / (人生の)重大な転機(岐路),重大事 / 最悪状態

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/10 05:39:13」(JST)

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Vaso-occlusive crisis
Classification and external resources
ICD-9-CM	282.62

A vaso-occlusive crisis is a common painful complication of sickle cell anemia in adolescents and adults. It is a form of sickle cell crisis. Sickle cell anemia – most common in those of African, Hispanic, and Mediterranean origin – leads to sickle cell crisis when the circulation of blood vessels is obstructed by sickled red blood cells, causing ischemic injuries. The most common complaint is of pain, and recurrent episodes may cause irreversible organ damage. One of the most severe forms is the acute chest syndrome which occurs as a result of infarction of the lung parenchyma. This can rapidly result in death. Other types of vaso-occlusive crisis in sickle cell anemia include dactylitis, priapism, abdominal pain, and jaundice.

Management

The management of an acute event of vaso-occlusive crisis is the use of potent analgesics (opioids), rehydration with normal saline or Ringer's lactate, treatment of malaria (whether symptomatic or not) using artemisinin combination therapy, and the use of oxygen via face mask, especially for acute chest syndrome. Hyperbaric oxygen has also been shown to be a useful adjunct in pain reduction. Antibiotics may be utilized because patients usually have occult infection due to a "functional asplenia".

UpToDate Contents

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• 1. 鎌状赤血球症の臨床症状の概要 overview of the clinical manifestations of sickle cell disease
• 2. 鎌状赤血球症のマネージメントおよび予後の概要 overview of the management and prognosis of sickle cell disease
• 3. 鎌状赤血球症における血管閉塞による疼痛のマネージメント vasoocclusive pain management in sickle cell disease
• 4. Mechanisms of vasoocclusion in sickle cell disease
• 5. 鎌状赤血球症を伴う成人における急性胸部症候群 acute chest syndrome in adults with sickle cell disease

English Journal

• Nucleosomes and neutrophil activation in sickle cell disease painful crisis.

• Schimmel M, Nur E, Biemond BJ, van Mierlo GJ, Solati S, Brandjes DP, Otten HM, Schnog JJ, Zeerleder S.SourceAcademic Medical Center;
• Haematologica.Haematologica.2013 Aug 2. [Epub ahead of print]
• Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation polymorphonuclear neutrophils can form neutrophil extracellular traps. Neutrophil extracellular traps consist of a meshwork of extracellular DNA, nucleosom
• PMID 23911704

• Peripartum acute liver failure from a vaso-occlusive crisis in a patient with sickle cell trait.

• Khozaim K, Schellinger M, Cummings O, Robinson B.SourceIndiana University School of Medicine, Department of Obstetrics and Gynecology, Indianapolis, IN, USA.
• Journal of perinatology : official journal of the California Perinatal Association.J Perinatol.2013 Aug;33(8):654-6. doi: 10.1038/jp.2013.31.
• Acute liver failure during pregnancy is a rare and potentially fatal occurrence. Sickle cell (SC) crises, when precipitated by pregnancy, usually affect patients with SC disease. We report a case of peripartum acute liver failure due to SC vaso-occlusive crisis of the liver in a patient with SC trai
• PMID 23897311

• Low-dose ketamine as a potential adjuvant therapy for painful vaso-occlusive crises in sickle cell disease.

• Neri CM, Pestieau SR, Darbari DS.SourceChildren's National Medical Center, Center for Cancer and Blood Disorders, Washington, DC, USA; Department of Pediatrics, School of Medicine, The George Washington University, Washington, DC, USA.
• Paediatric anaesthesia.Paediatr Anaesth.2013 Aug;23(8):684-9. doi: 10.1111/pan.12172. Epub 2013 Apr 9.
• The hallmark of sickle cell disease (SCD) is the acute painful vaso-occlusive crisis (VOC). Among SCD patients, vaso-occlusive pain episodes vary in frequency and severity. Some patients rarely have painful crises, while others are admitted to the hospital multiple times in a year for parenteral ana
• PMID 23565738

Related Links

• vaso-occlusive crisis - definition of vaso-occlusive crisis by ...

Black, MD: This 41-year-old African American woman with hemoglobin SC disease had recurrent cough; dyspnea; and chest, back, and leg pain consistent with a vaso-occlusive crisis involving the lungs, vertebral bodies, and long ...

• vaso-occlusive crisis - definition of vaso-occlusive crisis by ...

cri·sis (krī′sĭs) n. pl. cri·ses (-sēz) 1. A crucial or decisive point or situation, especially a difficult or unstable situation involving an impending ... These same clinical signs and symptoms also feature prominently in vaso-occlusive crisis ...

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★リンクテーブル★

リンク元	「血管閉塞性発作」
関連記事	「vas」「occlusive」

「血管閉塞性発作」

　　[★]

英

vaso-occlusive episode, vaso-occlusive crisis

[show details]

vaso-occlusive episode : 約 3,010 件
vaso-occlusive episodes : 約 45,800 件
vaso-occlusive crisis : 約 61,200 件
vaso-occlusive crises : 約 109,000 件

「vas」

　　[★]

• n.

• 管、(植物)導管

関

canal、conduit、duct、ductal、ductus、meatus、pipe、tubal、tube、vessel

「occlusive」

　　[★]

• 閉塞性の

関

constrictive、obliterans、obliterative、obstructive、occlusively