同: VCAM-1

WordNet

small room in which a monk or nun lives (同)cubicle
a device that delivers an electric current as the result of a chemical reaction (同)electric cell
a room where a prisoner is kept (同)jail cell, prison cell
(biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
any small compartment; "the cells of a honeycomb"
a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
a fibrous band of scar tissue that binds together normally separate anatomical structures
abnormal union of bodily tissues; most common in the abdomen
of or relating to or having vessels that conduct and circulate fluids; "vascular constriction"; "a vascular bundle"
(physics and chemistry) the simplest structural unit of an element or compound

PrepTutorEJDIC

(刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
粘着,付着
(血液・樹液などを運ぶ)管の,導管の,血管の
分子《略》『mol』) / (一般に)(…の)微量《+『of』+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/09 22:35:49」(JST)

wiki en

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene.^[1] VCAM-1 functions as a cell adhesion molecule.

Structure

The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after the endothelial cells are stimulated by cytokines. It is alternatively spliced into two known RNA transcripts that encode different isoforms in humans.^[2] The gene product is a cell surface sialoglycoprotein, a type I membrane protein that is a member of the Ig superfamily.

Function

The VCAM-1 protein mediates the adhesion of lymphocytes, monocytes, eosinophils, and basophils to vascular endothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.

Upregulation of VCAM-1 in endothelial cells by cytokines occurs as a result of increased gene transcription (e.g., in response to Tumor necrosis factor-alpha (TNF-α) and Interleukin-1 (IL-1)) and through stabilization of Messenger RNA (mRNA) (e.g., Interleukin-4 (IL-4)). The promoter region of the VCAM-1 gene contains functional tandem NF-κB (nuclear factor-kappa B) sites. The sustained expression of VCAM-1 lasts over 24 hours.

Primarily, the VCAM-1 protein is an endothelial ligand for VLA-4 (Very Late Antigen-4 or integrin α4β1) of the β1 subfamily of integrins. VCAM-1 expression has also been observed in other cell types (e.g., smooth muscle cells). It has also been shown to interact with EZR^[3] and Moesin.^[3]

Pharmacology

Certain melanoma cells can use VCAM-1 to adhere to the endothelium,^[4] and VCAM-1 may participate in monocyte recruitment to atherosclerotic sites. As a result, VCAM-1 is a potential drug target.

References

^ Cybulsky M, Fries JW, Williams AJ, Sultan P, Eddy RL, Byers MG, Shows TB, Gimbrone MA Jr, Collins T (1991). "The human VCAM1 gene is assigned to chromosome 1p31-p32". Cytogenet. Cell Genet. 58: 1852. doi:10.1159/000133735.
^ "Entrez Gene: VCAM1 vascular cell adhesion molecule 1".
^ ^a ^b Barreiro O, Yanez-Mo M, Serrador JM, Montoya MC, Vicente-Manzanares M, Tejedor R, Furthmayr H, Sanchez-Madrid F (Jun 2002). "Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes". J. Cell Biol. 157 (7): 1233–45. doi:10.1083/jcb.200112126. PMC 2173557. PMID 12082081.
^ Eibl RH and Benoit M (2004). "Molecular resolution of cell adhesion forces.". IEE Proc Nanobiotechnol. 151 (3): 128–32. doi:10.1049/ip-nbt:20040707. PMID 16475855.

External links

VCAM-1 at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 炎症の病因における白血球内皮細胞接着 leukocyte endothelial adhesion in the pathogenesis of inflammation
2. 内皮：プライマー the endothelium a primer
3. アテローム性動脈硬化症の病因 pathogenesis of atherosclerosis
4. 全身性硬化症（強皮症）の病因 pathogenesis of systemic sclerosis scleroderma
5. 心臓同種移植血管症の病因および危険因子 pathogenesis of and risk factors for cardiac allograft vasculopathy

English Journal

Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis.

Koulis C, Kanellakis P, Pickering RJ, Tsorotes D, Murphy AJ, Gray SP, Thomas MC, Jandeleit-Dahm KA, Cooper ME, Allen TJ.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Oct 1;127(7):485-97. doi: 10.1042/CS20140045.
RAGE (receptor for advanced glycation end-products) is expressed on multiple cell types implicated in the progression of atherosclerosis and plays a role in DAA (diabetes-associated atherosclerosis). The aim of the present study was to determine the relative role of either BM (bone marrow)- or non-
PMID 24724734

Resveratrol inhibits Staphylococcus aureus-induced TLR2/MyD88/NF-κB-dependent VCAM-1 expression in human lung epithelial cells.

Lee IT1, Lin CC2, Hsu CK1, Wu MY1, Cho RL1, Yang CM1.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Sep 1;127(6):375-90. doi: 10.1042/CS20130816.
Staphylococcus aureus is the most commonly found Gram-positive bacterium in patients admitted to intensive-care units, causing septicaemia or pneumonia. S. aureus is considered to play an important role in the induction of cell adhesion molecules. Resveratrol, a compound found in the skins of red fr
PMID 24617573

Nuclear factor-κB is involved in the protocadherin-10-mediated pro-apoptotic effect in multiple myeloma.

Li Z1, Yang Z1, Peng X1, Li Y2, Liu Q3, Chen J1.
Molecular medicine reports.Mol Med Rep.2014 Aug;10(2):832-8. doi: 10.3892/mmr.2014.2285. Epub 2014 May 29.
The gene encoding protocadherin-10 (PCDH10), a member of the cadherin superfamily, has been recently identified as a tumor suppressor gene (TSG). PCDH10 plays important roles in the apoptosis of tumor cells in some cancer types. However, the exact role of PCDH10 in multiple myeloma (MM) is largely
PMID 24888369

Japanese Journal

Eicosapentaenoic Acid Prevents Saturated Fatty Acid-Induced Vascular Endothelial Dysfunction: Involvement of Long-Chain Acyl-CoA Synthetase

Journal of Atherosclerosis and Thrombosis 22(11), 1172-1185, 2015
NAID 130005106116

多発性硬化症へのナタリツマブ治療

臨床神経学 55(8), 537-543, 2015
NAID 130005094159

多発性硬化症へのナタリツマブ治療

臨床神経学 advpub(0), 2015
NAID 130005087474

「VCAM-1」

Vascular cell adhesion molecule 1
	PDB rendering based on 1ij9.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1IJ9, 1VCA, 1VSC
Identifiers
Symbols	VCAM1 ; CD106; INCAM-100
External IDs	OMIM: 192225 MGI: 98926 HomoloGene: 838 ChEMBL: 3735 GeneCards: VCAM1 Gene
Gene ontology
Molecular function	• integrin binding; • primary amine oxidase activity; • cell adhesion molecule binding;
Cellular component	• podosome; • extracellular space; • early endosome; • endoplasmic reticulum; • Golgi apparatus; • plasma membrane; • microvillus; • external side of plasma membrane; • cell surface; • integral component of membrane; • filopodium; • apical part of cell; • extracellular exosome; • alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex;
Biological process	• cell adhesion; • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • leukocyte cell-cell adhesion; • cell-matrix adhesion; • amine metabolic process; • viral process; • cytokine-mediated signaling pathway; • membrane to membrane docking; • B cell differentiation; • extracellular matrix organization; • calcium-mediated signaling using intracellular calcium source; • positive regulation of T cell proliferation; • regulation of immune response; • leukocyte tethering or rolling; • oxidation-reduction process; • interferon-gamma-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;